CRCGN016_MCF10A.TP53.M_24H:J02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tiabendazole 33.82 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:J02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.0261
KDM5D lysine (K)-specific demethylase 5D 3.95688
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.43184
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.3411
PMM2 phosphomannomutase 2 3.0481
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.04127
HYOU1 hypoxia up-regulated 1 2.88353
USP9Y ubiquitin specific peptidase 9, Y-linked 2.88075
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.61604
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.61393
WDR76 WD repeat domain 76 2.45715
ZFY zinc finger protein, Y-linked 2.39661
HTD2 hydroxyacyl-thioester dehydratase type 2 2.35054
PDLIM1 PDZ and LIM domain 1 2.3142
CADM1 cell adhesion molecule 1 2.25923
PRKX protein kinase, X-linked 2.22968
CNRIP1 cannabinoid receptor interacting protein 1 2.21654
AURKB aurora kinase B 2.1808
WASHC5 WASH complex subunit 5 2.18005
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.17668
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 2.17
COQ8A coenzyme Q8A 2.12654
MMP2 matrix metallopeptidase 2 2.1172
GJD3 gap junction protein, delta 3, 31.9kDa 2.09359
NLGN4Y neuroligin 4, Y-linked 2.09193
FGFR4 fibroblast growth factor receptor 4 2.09078
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 2.0699
SOX11 SRY (sex determining region Y)-box 11 2.02155

decreased expression

Symbol Name Standardized Value
RPIA ribose 5-phosphate isomerase A -4.69244
TES testin LIM domain protein -4.09069
CCNB1 cyclin B1 -3.40468
IGFBP7 insulin-like growth factor binding protein 7 -3.21212
SMC1A structural maintenance of chromosomes 1A -3.15054
NOSIP nitric oxide synthase interacting protein -3.04369
COG2 component of oligomeric golgi complex 2 -2.91647
COTL1 coactosin-like F-actin binding protein 1 -2.83253
CLTB clathrin, light chain B -2.70886
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.61391
CD320 CD320 molecule -2.46352
ATF5 activating transcription factor 5 -2.45423
C1QBP complement component 1, q subcomponent binding protein -2.44403
CCDC86 coiled-coil domain containing 86 -2.34105
KDM5C lysine (K)-specific demethylase 5C -2.25056
MARCKSL1 MARCKS-like 1 -2.23356
NUP88 nucleoporin 88kDa -2.16551
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.15805
PUDP pseudouridine 5'-phosphatase -2.15296
UBA1 ubiquitin-like modifier activating enzyme 1 -2.13361
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.11483
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.08215
EFHD2 EF-hand domain family, member D2 -2.03656
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) -2.03317