CRCGN016_MCF10A.TP53.M_24H:J03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tiabendazole 11.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:J03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KDM5D lysine (K)-specific demethylase 5D 5.96223
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 5.0462
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 4.87311
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 4.8146
USP9Y ubiquitin specific peptidase 9, Y-linked 3.35522
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.07161
COMP cartilage oligomeric matrix protein 2.97744
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.81696
ZFY zinc finger protein, Y-linked 2.4898
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.42721
PXMP2 peroxisomal membrane protein 2, 22kDa 2.37779
RPS4Y1 ribosomal protein S4, Y-linked 1 2.22373
CADM1 cell adhesion molecule 1 2.1979
NLGN4Y neuroligin 4, Y-linked 2.07424

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -8.83699
SMC1A structural maintenance of chromosomes 1A -4.91361
KDM5C lysine (K)-specific demethylase 5C -4.90117
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.84475
SGK1 serum/glucocorticoid regulated kinase 1 -4.71349
COTL1 coactosin-like F-actin binding protein 1 -4.46675
OXA1L oxidase (cytochrome c) assembly 1-like -4.0952
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -3.84757
TUBA4A tubulin, alpha 4a -3.55635
UBA1 ubiquitin-like modifier activating enzyme 1 -3.52159
KDM6A lysine (K)-specific demethylase 6A -3.38928
GDF15 growth differentiation factor 15 -3.33945
MFSD12 major facilitator superfamily domain containing 12 -3.33678
PUDP pseudouridine 5'-phosphatase -3.27028
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -3.12865
USP9X ubiquitin specific peptidase 9, X-linked -2.9783
AK5 adenylate kinase 5 -2.41212
SQSTM1 sequestosome 1 -2.33639
PNPLA4 patatin-like phospholipase domain containing 4 -2.28245
TEX10 testis expressed 10 -2.24627
OFD1 oral-facial-digital syndrome 1 -2.23877
WDR11 WD repeat domain 11 -2.19814
PDZD2 PDZ domain containing 2 -2.19279
EGR3 early growth response 3 -2.12102
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -2.07462
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.07214
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) -2.05157
TXLNG taxilin gamma -2.03594
AKAP17A A kinase (PRKA) anchor protein 17A -2.03257