CRCGN016_MCF10A.TP53.M_24H:J05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dioxane 34.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:J05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 4.07127
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.80556
EAPP E2F-associated phosphoprotein 3.75789
LGMN legumain 3.49151
PROS1 protein S (alpha) 3.43846
LAGE3 L antigen family, member 3 3.38975
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.3833
WFS1 Wolfram syndrome 1 (wolframin) 3.20697
HBA1 hemoglobin, alpha 1 3.14351
KIF5C kinesin family member 5C 2.77479
SRP54 signal recognition particle 54kDa 2.52656
MEIS2 Meis homeobox 2 2.39733
E2F2 E2F transcription factor 2 2.35721
DENND2D DENN/MADD domain containing 2D 2.31866
RNASE4 ribonuclease, RNase A family, 4 2.31397
HBB hemoglobin, beta 2.30901
DENND2B DENN domain containing 2B 2.25359
MAP2K5 mitogen-activated protein kinase kinase 5 2.23201
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 2.2174
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 2.1284
SEC14L4 SEC14-like 4 (S. cerevisiae) 2.09643
MNS1 meiosis-specific nuclear structural 1 2.07432
RNF103 ring finger protein 103 2.05275
FAM110A family with sequence similarity 110, member A 2.03386
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.03222
VAMP7 vesicle-associated membrane protein 7 2.01766
APOA2 apolipoprotein A-II 2.01688

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -4.77831
COTL1 coactosin-like F-actin binding protein 1 -4.57907
TUBA4A tubulin, alpha 4a -4.447
UFM1 ubiquitin-fold modifier 1 -4.32213
TNIP1 TNFAIP3 interacting protein 1 -4.22781
PCNA proliferating cell nuclear antigen -4.04049
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.96769
HSPA8 heat shock 70kDa protein 8 -3.72772
NRIP1 nuclear receptor interacting protein 1 -3.50577
LYPLA1 lysophospholipase I -3.4117
TKT transketolase -3.40681
PRPF4 pre-mRNA processing factor 4 -3.40486
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.2241
PMM2 phosphomannomutase 2 -3.12919
MT1X metallothionein 1X -3.0336
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.98193
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.81516
HOXA5 homeobox A5 -2.58041
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -2.52223
ATP5F1E ATP synthase F1 subunit epsilon -2.41897
RTRAF RNA transcription, translation and transport factor -2.41315
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.41199
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.39764
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -2.37871
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) -2.33156
URGCP upregulator of cell proliferation -2.3312
REEP5 receptor accessory protein 5 -2.31496
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.26254
PROSER1 proline and serine rich 1 -2.2346
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.16575
IGFLR1 IGF-like family receptor 1 -2.13165
SMC1A structural maintenance of chromosomes 1A -2.12029
HAT1 histone acetyltransferase 1 -2.10249
COX5A cytochrome c oxidase subunit Va -2.10153
EIF3H eukaryotic translation initiation factor 3, subunit H -2.08951
FKBP9 FK506 binding protein 9, 63 kDa -2.00428