CRCGN016_MCF10A.TP53.M_24H:J11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethylnitrosamine 33.1 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:J11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 6.00876
WFS1 Wolfram syndrome 1 (wolframin) 5.08279
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 4.94197
STIMATE STIM activating enhancer 4.67989
KDM5D lysine (K)-specific demethylase 5D 4.23981
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 4.15027
TSPAN6 tetraspanin 6 3.48113
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.38116
ACAA1 acetyl-CoA acyltransferase 1 3.34762
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.30087
USP9Y ubiquitin specific peptidase 9, Y-linked 2.99254
SOCS2 suppressor of cytokine signaling 2 2.93075
COPS7A COP9 signalosome subunit 7A 2.7669
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 2.76596
BACE2 beta-site APP-cleaving enzyme 2 2.72791
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.67474
STK32B serine/threonine kinase 32B 2.58253
GLOD4 glyoxalase domain containing 4 2.43896
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.42841
PEX12 peroxisomal biogenesis factor 12 2.42657
KIF4A kinesin family member 4A 2.41672
APH1B APH1B gamma secretase subunit 2.35137
SBNO1 strawberry notch homolog 1 (Drosophila) 2.32774
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.29004
ELF2 E74-like factor 2 (ets domain transcription factor) 2.27525
NLGN4Y neuroligin 4, Y-linked 2.26517
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.25982
MBIP MAP3K12 binding inhibitory protein 1 2.22236
BBS7 Bardet-Biedl syndrome 7 2.184
COQ8A coenzyme Q8A 2.13607
MUC7 mucin 7, secreted 2.12063
SMR3B submaxillary gland androgen regulated protein 3B 2.1191
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.0945
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.07617
TMEM168 transmembrane protein 168 2.05342
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.04988
EAPP E2F-associated phosphoprotein 2.04618
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.03689
FOXJ3 forkhead box J3 2.03189
CCDC170 coiled-coil domain containing 170 2.00209

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -5.57518
ATF5 activating transcription factor 5 -4.26135
MEST mesoderm specific transcript -4.25007
UFM1 ubiquitin-fold modifier 1 -4.13721
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.86396
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.85287
OAT ornithine aminotransferase -3.67491
SGK1 serum/glucocorticoid regulated kinase 1 -3.6552
NRIP1 nuclear receptor interacting protein 1 -3.46615
CAPN2 calpain 2, (m/II) large subunit -3.38147
COTL1 coactosin-like F-actin binding protein 1 -3.06606
FAM131A family with sequence similarity 131, member A -2.61095
SMC1A structural maintenance of chromosomes 1A -2.56312
MAP2K1 mitogen-activated protein kinase kinase 1 -2.54475
CIAO2B cytosolic iron-sulfur assembly component 2B -2.46409
CD52 CD52 molecule -2.45134
CRABP2 cellular retinoic acid binding protein 2 -2.32406
ANXA2 annexin A2 -2.31048
KDM5C lysine (K)-specific demethylase 5C -2.28844
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.27392
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.2703
THAP11 THAP domain containing 11 -2.15691
EXOSC8 exosome component 8 -2.14853
COG7 component of oligomeric golgi complex 7 -2.14005
APIP APAF1 interacting protein -2.12032
GDF15 growth differentiation factor 15 -2.0954
KRT8 keratin 8, type II -2.08255
STAT4 signal transducer and activator of transcription 4 -2.02422