CRCGN016_MCF10A.TP53.M_24H:J12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethylnitrosamine 11.03 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

92 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:J12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 6.78445
HBA1 hemoglobin, alpha 1 4.61476
PHKG2 phosphorylase kinase, gamma 2 (testis) 3.73773
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.61994
ZNF586 zinc finger protein 586 3.36718
TLR8 toll-like receptor 8 3.30059
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 3.24033
FPR2 formyl peptide receptor 2 3.23081
PDLIM1 PDZ and LIM domain 1 3.16819
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.15368
PRKCH protein kinase C, eta 3.10724
ZNF134 zinc finger protein 134 3.09937
ABHD6 abhydrolase domain containing 6 3.032
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.00517
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.97592
TLR1 toll-like receptor 1 2.92667
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 2.90577
GASK1B golgi associated kinase 1B 2.86061
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 2.84392
HBB hemoglobin, beta 2.73667
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 2.68185
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.63696
AOAH acyloxyacyl hydrolase (neutrophil) 2.6129
ZNF211 zinc finger protein 211 2.52823
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.50574
FGFR4 fibroblast growth factor receptor 4 2.47896
CLEC7A C-type lectin domain family 7, member A 2.47471
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.46654
PILRA paired immunoglobin-like type 2 receptor alpha 2.43946
CCR1 chemokine (C-C motif) receptor 1 2.40105
ESRP2 epithelial splicing regulatory protein 2 2.3922
MARCHF1 membrane associated ring-CH-type finger 1 2.38078
NPIPB6 nuclear pore complex interacting protein family, member B6 2.35381
RBKS ribokinase 2.30762
GCA grancalcin, EF-hand calcium binding protein 2.30199
PTPRJ protein tyrosine phosphatase, receptor type, J 2.29482
DMXL2 Dmx-like 2 2.29447
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 2.28774
CLEC4A C-type lectin domain family 4, member A 2.27618
MEGF9 multiple EGF-like-domains 9 2.27107
CCR2 chemokine (C-C motif) receptor 2 2.26937
MNDA myeloid cell nuclear differentiation antigen 2.26218
TFEC transcription factor EC 2.25292
RBM47 RNA binding motif protein 47 2.24224
CADPS2 Ca++-dependent secretion activator 2 2.24172
CALCRL calcitonin receptor-like 2.23744
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 2.21812
CPPED1 calcineurin-like phosphoesterase domain containing 1 2.19484
KYNU kynureninase 2.1908
OSBPL11 oxysterol binding protein-like 11 2.18456
ZEB2 zinc finger E-box binding homeobox 2 2.18285
MICALL1 MICAL-like 1 2.15508
AZU1 azurocidin 1 2.15387
C5AR1 complement component 5a receptor 1 2.1357
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.12412
NBR1 neighbor of BRCA1 gene 1 2.11251
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 2.10865
FPR1 formyl peptide receptor 1 2.10071
DHDDS dehydrodolichyl diphosphate synthase 2.08196
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 2.06607
ZNF761 zinc finger protein 761 2.05777
CORO1C coronin, actin binding protein, 1C 2.01319
SNX11 sorting nexin 11 2.01235
UBE2D1 ubiquitin-conjugating enzyme E2D 1 2.01174
TUFM Tu translation elongation factor, mitochondrial 2.00939
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 2.00738
ANKFY1 ankyrin repeat and FYVE domain containing 1 2.00591
VAMP3 vesicle-associated membrane protein 3 2.00474
WDFY3 WD repeat and FYVE domain containing 3 2.00318

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -3.30887
GDF15 growth differentiation factor 15 -3.29543
MRPS16 mitochondrial ribosomal protein S16 -2.90358
CD320 CD320 molecule -2.73924
KRT14 keratin 14, type I -2.60191
TCL1A T-cell leukemia/lymphoma 1A -2.57593
SPRY4 sprouty homolog 4 (Drosophila) -2.56318
ATP5F1E ATP synthase F1 subunit epsilon -2.54043
TLK2 tousled-like kinase 2 -2.43096
PANK2 pantothenate kinase 2 -2.38583
DDRGK1 DDRGK domain containing 1 -2.30474
GNAS GNAS complex locus -2.28697
E2F5 E2F transcription factor 5, p130-binding -2.25789
TUBA4A tubulin, alpha 4a -2.2413
BPHL biphenyl hydrolase-like (serine hydrolase) -2.1794
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.16467
CD79B CD79b molecule, immunoglobulin-associated beta -2.15942
FKBP1C FK506 binding protein 1C -2.1364
CAMLG calcium modulating ligand -2.09091
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -2.08643
ATP11B ATPase, class VI, type 11B -2.05629
ZFHX4 zinc finger homeobox 4 -2.01709
CDCP1 CUB domain containing protein 1 -2.0059