CRCGN016_MCF10A.TP53.M_24H:J16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

23 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:J16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.80312
CISD1 CDGSH iron sulfur domain 1 3.49397
ACAA1 acetyl-CoA acyltransferase 1 3.40061
WFS1 Wolfram syndrome 1 (wolframin) 3.26038
MCUR1 mitochondrial calcium uniporter regulator 1 2.90984
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.74173
KIF5C kinesin family member 5C 2.70277
SQOR sulfide quinone oxidoreductase 2.50223
NUTF2 nuclear transport factor 2 2.30291
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.23014
MTA2 metastasis associated 1 family, member 2 2.20492
GSR glutathione reductase 2.08376

decreased expression

Symbol Name Standardized Value
BASP1 brain abundant, membrane attached signal protein 1 -4.69137
SGK1 serum/glucocorticoid regulated kinase 1 -3.6847
OXA1L oxidase (cytochrome c) assembly 1-like -3.10073
TUBB6 tubulin, beta 6 class V -3.05877
VDAC1 voltage-dependent anion channel 1 -2.87453
ATF5 activating transcription factor 5 -2.86942
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.82286
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.76149
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.73256
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.4409
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.04379