CRCGN016_MCF10A.TP53.M_24H:J17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:J17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KDM5D lysine (K)-specific demethylase 5D 6.92426
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 5.70785
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 5.63592
GPER1 G protein-coupled estrogen receptor 1 4.66555
HBA1 hemoglobin, alpha 1 4.44634
USP9Y ubiquitin specific peptidase 9, Y-linked 4.01479
MAST2 microtubule associated serine/threonine kinase 2 3.64494
GPATCH8 G patch domain containing 8 3.39737
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 3.1626
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.11439
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.06318
EPHB2 EPH receptor B2 2.97959
TLCD3A TLC domain containing 3A 2.91895
CNRIP1 cannabinoid receptor interacting protein 1 2.7254
CETN3 centrin, EF-hand protein, 3 2.66143
AGR2 anterior gradient 2 2.66109
MELK maternal embryonic leucine zipper kinase 2.61625
TSPAN6 tetraspanin 6 2.58559
CPPED1 calcineurin-like phosphoesterase domain containing 1 2.52389
TPD52L2 tumor protein D52-like 2 2.49915
HBB hemoglobin, beta 2.48262
HABP4 hyaluronan binding protein 4 2.43759
NLGN4Y neuroligin 4, Y-linked 2.43182
BTK Bruton agammaglobulinemia tyrosine kinase 2.38477
PEX2 peroxisomal biogenesis factor 2 2.3765
RPS4Y1 ribosomal protein S4, Y-linked 1 2.37433
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.3471
ABHD18 abhydrolase domain containing 18 2.34058
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 2.30659
NT5C2 5'-nucleotidase, cytosolic II 2.29104
NSF N-ethylmaleimide-sensitive factor 2.27438
ZEB2 zinc finger E-box binding homeobox 2 2.24952
ZFY zinc finger protein, Y-linked 2.23158
PAAF1 proteasomal ATPase-associated factor 1 2.21899
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 2.16598
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog 2.14143
ELP4 elongator acetyltransferase complex subunit 4 2.13184
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.12579
TRMT61B tRNA methyltransferase 61B 2.10579
LAMA2 laminin, alpha 2 2.09787
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.09266
ACAA1 acetyl-CoA acyltransferase 1 2.08979
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.05547
SMAD3 SMAD family member 3 2.04473
CPZ carboxypeptidase Z 2.04385
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.0426
TCTN3 tectonic family member 3 2.02345
CAPN1 calpain 1, (mu/I) large subunit 2.02304
ANKRD28 ankyrin repeat domain 28 2.00087

decreased expression

Symbol Name Standardized Value
LAP3 leucine aminopeptidase 3 -5.67532
SMC1A structural maintenance of chromosomes 1A -5.49435
SGK1 serum/glucocorticoid regulated kinase 1 -4.81937
YME1L1 YME1-like 1 ATPase -4.65481
C2CD5 C2 calcium-dependent domain containing 5 -4.65152
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -4.4741
PUDP pseudouridine 5'-phosphatase -4.10337
CIAPIN1 cytokine induced apoptosis inhibitor 1 -4.01897
KDM5C lysine (K)-specific demethylase 5C -3.85377
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -3.37667
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -3.37157
KDM6A lysine (K)-specific demethylase 6A -3.3122
USP9X ubiquitin specific peptidase 9, X-linked -3.12837
UBA1 ubiquitin-like modifier activating enzyme 1 -3.10725
KDM3A lysine (K)-specific demethylase 3A -2.68189
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.48595
PNPLA4 patatin-like phospholipase domain containing 4 -2.39645
GMCL1 germ cell-less, spermatogenesis associated 1 -2.362
ATP11B ATPase, class VI, type 11B -2.2706
TRIB3 tribbles pseudokinase 3 -2.23227
STAU1 staufen double-stranded RNA binding protein 1 -2.19737
HSPA4 heat shock 70kDa protein 4 -2.17965
HIRA histone cell cycle regulator -2.15128
PCGF1 polycomb group ring finger 1 -2.12943
SHROOM2 shroom family member 2 -2.10381
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -2.08083
SLC6A16 solute carrier family 6, member 16 -2.06031
RBM15B RNA binding motif protein 15B -2.04893
RTN1 reticulon 1 -2.01087