CRCGN016_MCF10A.TP53.M_24H:J23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrazinamide 33.32 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:J23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 4.93824
TBX2 T-box 2 4.92207
METRN meteorin, glial cell differentiation regulator 4.14962
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.53127
IGHMBP2 immunoglobulin mu binding protein 2 3.01956
NISCH nischarin 2.87133
MVB12B multivesicular body subunit 12B 2.49832
ANGPTL7 angiopoietin-like 7 2.44568
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.44211
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 2.38223
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.31179
CPT1A carnitine palmitoyltransferase 1A (liver) 2.29662
PAX9 paired box 9 2.29648
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.28538
ZFHX3 zinc finger homeobox 3 2.2629
LAMB1 laminin, beta 1 2.24166
RAI14 retinoic acid induced 14 2.22701
EDN1 endothelin 1 2.14874
AGBL2 ATP/GTP binding protein-like 2 2.11148
MYO9A myosin IXA 2.09376
OBP2B odorant binding protein 2B 2.09275
UPK3B uroplakin 3B 2.06576
SFTPD surfactant protein D 2.06017
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.03188
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.01685
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 2.01353
GSTA3 glutathione S-transferase alpha 3 2.011

decreased expression

Symbol Name Standardized Value
PARP2 poly (ADP-ribose) polymerase 2 -5.18538
PCCB propionyl CoA carboxylase, beta polypeptide -5.14811
KRT14 keratin 14, type I -4.96181
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.72176
TNIP1 TNFAIP3 interacting protein 1 -4.64771
MSN moesin -4.56667
GTPBP8 GTP-binding protein 8 (putative) -4.36823
TRAPPC3 trafficking protein particle complex 3 -4.11404
TM9SF3 transmembrane 9 superfamily member 3 -3.932
THAP11 THAP domain containing 11 -3.49867
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.47162
MPC2 mitochondrial pyruvate carrier 2 -3.00128
SLC35A5 solute carrier family 35, member A5 -2.91018
MAT2B methionine adenosyltransferase II, beta -2.73434
NR1D2 nuclear receptor subfamily 1, group D, member 2 -2.62148
MRPS15 mitochondrial ribosomal protein S15 -2.58127
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -2.48769
IFRD2 interferon-related developmental regulator 2 -2.48699
ANKRD40 ankyrin repeat domain 40 -2.48279
RBM22 RNA binding motif protein 22 -2.46532
MAP7D1 MAP7 domain containing 1 -2.44258
BBX bobby sox homolog (Drosophila) -2.34759
ABHD10 abhydrolase domain containing 10 -2.30462
TUSC2 tumor suppressor candidate 2 -2.26306
NCKIPSD NCK interacting protein with SH3 domain -2.20898
OSGEP O-sialoglycoprotein endopeptidase -2.18016
MAP2K1 mitogen-activated protein kinase kinase 1 -2.14405
CCP110 centriolar coiled coil protein 110kDa -2.11852
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) -2.08644
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.07826
FHIT fragile histidine triad -2.07222
MCTP1 multiple C2 domains, transmembrane 1 -2.05535
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -2.05312
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.05099
TFF1 trefoil factor 1 -2.04866
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa -2.03836
MAGED4B melanoma antigen family D4B -2.03134
TMEM39B transmembrane protein 39B -2.00969