CRCGN016_MCF10A.TP53.M_24H:J24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrazinamide 11.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:J24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 5.32507
E2F2 E2F transcription factor 2 5.19504
ABHD4 abhydrolase domain containing 4 5.04323
CNRIP1 cannabinoid receptor interacting protein 1 4.12578
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.53811
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.90813
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.69998
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 2.55021
TUBB4B tubulin, beta 4B class IVb 2.52344
EPN2 epsin 2 2.41931
PARN poly(A)-specific ribonuclease 2.33647
PRDX1 peroxiredoxin 1 2.1791
CBR4 carbonyl reductase 4 2.07947
MGST3 microsomal glutathione S-transferase 3 2.06008
FAM32A family with sequence similarity 32, member A 2.03694
ACAA1 acetyl-CoA acyltransferase 1 2.03242
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2.02844
HMBOX1 homeobox containing 1 2.00654

decreased expression

Symbol Name Standardized Value
TES testin LIM domain protein -4.89975
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.86655
CDK4 cyclin-dependent kinase 4 -3.99425
BID BH3 interacting domain death agonist -3.92573
PCCB propionyl CoA carboxylase, beta polypeptide -3.7274
IFRD2 interferon-related developmental regulator 2 -3.16162
TTC4 tetratricopeptide repeat domain 4 -2.73136
CEPT1 choline/ethanolamine phosphotransferase 1 -2.65674
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.41428
METTL1 methyltransferase like 1 -2.39176
SPAG4 sperm associated antigen 4 -2.21819
FHIT fragile histidine triad -2.21299
TUSC2 tumor suppressor candidate 2 -2.14972
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -2.13821
APEH acylaminoacyl-peptide hydrolase -2.12951
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -2.12646
HAX1 HCLS1 associated protein X-1 -2.12366
BAK1 BCL2-antagonist/killer 1 -2.11152
FAM50B family with sequence similarity 50, member B -2.0905
MRPL58 mitochondrial ribosomal protein L58 -2.08845
ACYP2 acylphosphatase 2, muscle type -2.07703
JMJD4 jumonji domain containing 4 -2.04957
TMEM115 transmembrane protein 115 -2.02778