CRCGN016_MCF10A.TP53.M_24H:K03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phthalamide 11.14 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:K03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 4.67858
AMDHD2 amidohydrolase domain containing 2 3.66006
GATA2 GATA binding protein 2 3.61132
ZNF318 zinc finger protein 318 3.58236
FGFR4 fibroblast growth factor receptor 4 3.54305
CGRRF1 cell growth regulator with ring finger domain 1 3.2811
TBPL1 TBP-like 1 2.89019
DENND2D DENN/MADD domain containing 2D 2.68623
MCUR1 mitochondrial calcium uniporter regulator 1 2.63953
ACBD3 acyl-CoA binding domain containing 3 2.58199
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.57174
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.34631
TSPAN6 tetraspanin 6 2.33692
PCOLCE2 procollagen C-endopeptidase enhancer 2 2.2925
LIN7A lin-7 homolog A (C. elegans) 2.24989
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 2.12675
LPL lipoprotein lipase 2.02124
SYNGAP1 synaptic Ras GTPase activating protein 1 2.01972

decreased expression

Symbol Name Standardized Value
GOLT1B golgi transport 1B -4.81607
ATF5 activating transcription factor 5 -4.5117
MAPK13 mitogen-activated protein kinase 13 -4.3138
HSPA1A heat shock 70kDa protein 1A -4.30415
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.98453
PRPF4 pre-mRNA processing factor 4 -3.87869
KIF14 kinesin family member 14 -3.87119
TRAP1 TNF receptor-associated protein 1 -3.50869
RALGDS ral guanine nucleotide dissociation stimulator -3.49528
MT1X metallothionein 1X -3.18979
TIMP1 TIMP metallopeptidase inhibitor 1 -2.64065
IGFBP7 insulin-like growth factor binding protein 7 -2.46102
TUBA4A tubulin, alpha 4a -2.43331
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.30245
BASP1 brain abundant, membrane attached signal protein 1 -2.29754
THAP11 THAP domain containing 11 -2.25875
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.25465
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.25058
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.24755
FKBP15 FK506 binding protein 15, 133kDa -2.24441
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.1573
ATG3 autophagy related 3 -2.15227
INTS13 integrator complex subunit 13 -2.12453
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -2.11646
KRT14 keratin 14, type I -2.11024
PRCP prolylcarboxypeptidase (angiotensinase C) -2.08771