CRCGN016_MCF10A.TP53.M_24H:K11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description wortmannin 3.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

727 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:K11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IL1B interleukin 1, beta 4.81318
CRELD2 cysteine-rich with EGF-like domains 2 3.99732
CERK ceramide kinase 3.99245
CDC45 cell division cycle 45 3.98475
NOTCH1 notch 1 3.97549
GHR growth hormone receptor 3.95846
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.92228
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.8211
SQOR sulfide quinone oxidoreductase 3.7168
ADRB2 adrenoceptor beta 2, surface 3.6964
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.44708
DKK3 dickkopf WNT signaling pathway inhibitor 3 3.39529
PHKG2 phosphorylase kinase, gamma 2 (testis) 3.38257
CCDC92 coiled-coil domain containing 92 3.35757
CIAO3 cytosolic iron-sulfur assembly component 3 3.33474
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.30285
CXCL2 chemokine (C-X-C motif) ligand 2 3.27614
PTK2B protein tyrosine kinase 2 beta 3.18288
STARD5 StAR-related lipid transfer (START) domain containing 5 3.13723
ARL4C ADP-ribosylation factor-like 4C 3.13345
FGFR4 fibroblast growth factor receptor 4 3.11312
FAT1 FAT atypical cadherin 1 3.0926
EDN1 endothelin 1 3.08375
JAG1 jagged 1 3.06997
DOCK4 dedicator of cytokinesis 4 3.05828
RCL1 RNA terminal phosphate cyclase-like 1 3.05702
EGF epidermal growth factor 3.04711
ACVRL1 activin A receptor type II-like 1 3.00965
HBA1 hemoglobin, alpha 1 3.00069
TLR4 toll-like receptor 4 2.95198
ZC3H12A zinc finger CCCH-type containing 12A 2.94517
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.94455
JMJD4 jumonji domain containing 4 2.92156
IPO13 importin 13 2.90205
NUAK1 NUAK family, SNF1-like kinase, 1 2.89897
LDOC1 leucine zipper, down-regulated in cancer 1 2.8933
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.88652
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 2.87795
DPEP1 dipeptidase 1 (renal) 2.87551
SLCO3A1 solute carrier organic anion transporter family, member 3A1 2.85618
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 2.85589
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.82846
ZG16 zymogen granule protein 16 2.82536
HAO2 hydroxyacid oxidase 2 (long chain) 2.82235
DCAF4 DDB1 and CUL4 associated factor 4 2.81487
AP4M1 adaptor-related protein complex 4, mu 1 subunit 2.80982
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 2.80697
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.80527
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 2.80114
BZW2 basic leucine zipper and W2 domains 2 2.80091
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 2.80084
RAI14 retinoic acid induced 14 2.79964
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 2.78295
MUC2 mucin 2, oligomeric mucus/gel-forming 2.76418
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.76389
ITFG1 integrin alpha FG-GAP repeat containing 1 2.75018
PLGLB2 plasminogen-like B2 2.74802
ARHGAP25 Rho GTPase activating protein 25 2.74542
IL15RA interleukin 15 receptor, alpha 2.7448
NOX1 NADPH oxidase 1 2.74296
ELL3 elongation factor RNA polymerase II-like 3 2.74097
CCRL2 chemokine (C-C motif) receptor-like 2 2.74075
IVNS1ABP influenza virus NS1A binding protein 2.73976
SLC26A6 solute carrier family 26 (anion exchanger), member 6 2.732
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.71876
RUSC2 RUN and SH3 domain containing 2 2.70818
IRF9 interferon regulatory factor 9 2.68599
FGFR2 fibroblast growth factor receptor 2 2.67363
BPHL biphenyl hydrolase-like (serine hydrolase) 2.66602
PDLIM1 PDZ and LIM domain 1 2.65261
CXXC4 CXXC finger protein 4 2.64557
CAPN9 calpain 9 2.64283
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.63942
MOK MOK protein kinase 2.63061
VNN1 vanin 1 2.63046
NTF3 neurotrophin 3 2.61435
ENTREP2 endosomal transmembrane epsin interactor 2 2.61172
HDGFL3 HDGF like 3 2.61144
IFT140 intraflagellar transport 140 2.60405
JAG2 jagged 2 2.6014
GSDMB gasdermin B 2.60095
FST follistatin 2.58626
MAPK12 mitogen-activated protein kinase 12 2.58434
GEMIN8 gem (nuclear organelle) associated protein 8 2.58281
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.58206
IL4R interleukin 4 receptor 2.57834
CTSD cathepsin D 2.564
PXDC1 PX domain containing 1 2.56218
HTRA1 HtrA serine peptidase 1 2.55871
SBDS Shwachman-Bodian-Diamond syndrome 2.55708
C8G complement component 8, gamma polypeptide 2.55617
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 2.551
ALG12 ALG12, alpha-1,6-mannosyltransferase 2.54036
JRKL JRK-like 2.53963
SPINK4 serine peptidase inhibitor, Kazal type 4 2.53449
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.53319
UGDH UDP-glucose 6-dehydrogenase 2.52669
STON1 stonin 1 2.52621
DNAI4 dynein axonemal intermediate chain 4 2.52544
TRAP1 TNF receptor-associated protein 1 2.52522
ZNF232 zinc finger protein 232 2.52211
MYO1D myosin ID 2.51857
ARSA arylsulfatase A 2.5104
HABP2 hyaluronan binding protein 2 2.50874
FETUB fetuin B 2.50572
GRB7 growth factor receptor-bound protein 7 2.5048
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 2.50068
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.49363
WNT6 wingless-type MMTV integration site family, member 6 2.48678
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 2.4822
DRAM1 DNA-damage regulated autophagy modulator 1 2.47255
CDHR1 cadherin-related family member 1 2.47141
RASA2 RAS p21 protein activator 2 2.4702
TNIP1 TNFAIP3 interacting protein 1 2.45938
ARID5B AT rich interactive domain 5B (MRF1-like) 2.45512
LPA lipoprotein, Lp(a) 2.45505
KANK1 KN motif and ankyrin repeat domains 1 2.45087
CDCA4 cell division cycle associated 4 2.44434
EDN2 endothelin 2 2.44344
ARHGAP8 Rho GTPase activating protein 8 2.44254
GATA3 GATA binding protein 3 2.43992
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.43792
ATG10 autophagy related 10 2.43256
MUS81 MUS81 structure-specific endonuclease subunit 2.42442
KDM8 lysine (K)-specific demethylase 8 2.42291
THBS3 thrombospondin 3 2.4227
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa 2.42208
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.42091
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 2.42074
TIMP2 TIMP metallopeptidase inhibitor 2 2.42062
CCDC85B coiled-coil domain containing 85B 2.41659
CCL24 chemokine (C-C motif) ligand 24 2.41516
RTN2 reticulon 2 2.4148
EXD3 exonuclease 3'-5' domain containing 3 2.4128
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.40883
LCAT lecithin-cholesterol acyltransferase 2.40234
CRHBP corticotropin releasing hormone binding protein 2.40218
VGLL4 vestigial-like family member 4 2.40021
LOC122526780 uncharacterized LOC122526780 2.39957
GRM8 glutamate receptor, metabotropic 8 2.39944
LEFTY1 left-right determination factor 1 2.38698
FRMPD1 FERM and PDZ domain containing 1 2.38655
FHL2 four and a half LIM domains 2 2.38579
RIPK4 receptor-interacting serine-threonine kinase 4 2.37234
TEDC2 tubulin epsilon and delta complex 2 2.37156
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.37123
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.36965
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.36822
HPS6 Hermansky-Pudlak syndrome 6 2.36597
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 2.36512
CSNK1E casein kinase 1, epsilon 2.36434
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.36146
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.35418
RMDN3 regulator of microtubule dynamics 3 2.34944
ZBED4 zinc finger, BED-type containing 4 2.34778
TEX13A testis expressed 13A 2.34299
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 2.34214
CISH cytokine inducible SH2-containing protein 2.33692
EPHB3 EPH receptor B3 2.33597
ATXN10 ataxin 10 2.33386
ANGPTL2 angiopoietin-like 2 2.33194
TMEM19 transmembrane protein 19 2.33117
COL17A1 collagen, type XVII, alpha 1 2.32972
APOF apolipoprotein F 2.31823
PDCD1LG2 programmed cell death 1 ligand 2 2.31424
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.31365
DOC2A double C2-like domains, alpha 2.31144
TNIP3 TNFAIP3 interacting protein 3 2.30758
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.30435
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.30166
PRKX protein kinase, X-linked 2.29909
ARSL arylsulfatase L 2.2973
CSPP1 centrosome and spindle pole associated protein 1 2.29654
LRP6 low density lipoprotein receptor-related protein 6 2.29416
GATA2 GATA binding protein 2 2.29365
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase 2.29122
ZNF706 zinc finger protein 706 2.29024
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.29019
LPCAT4 lysophosphatidylcholine acyltransferase 4 2.29008
ARL15 ADP-ribosylation factor-like 15 2.28957
TTLL12 tubulin tyrosine ligase-like family member 12 2.28577
TRAPPC14 trafficking protein particle complex subunit 14 2.28515
IFNG interferon, gamma 2.27953
GK2 glycerol kinase 2 2.27825
CCL20 chemokine (C-C motif) ligand 20 2.27718
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.27553
MMRN2 multimerin 2 2.27466
CKMT1A creatine kinase, mitochondrial 1A 2.27081
COA7 cytochrome c oxidase assembly factor 7 (putative) 2.26968
WDR7 WD repeat domain 7 2.2646
RGS11 regulator of G-protein signaling 11 2.2629
PLN phospholamban 2.26277
AMDHD2 amidohydrolase domain containing 2 2.2613
NSUN5 NOP2/Sun domain family, member 5 2.26099
ATOH1 atonal homolog 1 (Drosophila) 2.25778
RBM41 RNA binding motif protein 41 2.25712
NVL nuclear VCP-like 2.25696
REG1B regenerating islet-derived 1 beta 2.25567
GPR32 G protein-coupled receptor 32 2.25397
PROX1 prospero homeobox 1 2.25232
PLCH2 phospholipase C, eta 2 2.25205
USP9Y ubiquitin specific peptidase 9, Y-linked 2.2509
RDH16 retinol dehydrogenase 16 (all-trans) 2.25032
TWNK twinkle mtDNA helicase 2.24875
RECK reversion-inducing-cysteine-rich protein with kazal motifs 2.2482
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa 2.24781
CCL14 chemokine (C-C motif) ligand 14 2.24558
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 2.24148
PTPRU protein tyrosine phosphatase, receptor type, U 2.23997
ACVR2B activin A receptor, type IIB 2.23582
CPT1B carnitine palmitoyltransferase 1B (muscle) 2.23391
ACHE acetylcholinesterase (Yt blood group) 2.23365
ZNF500 zinc finger protein 500 2.23276
SMAD7 SMAD family member 7 2.23207
ZNF85 zinc finger protein 85 2.23178
PDZK1IP1 PDZK1 interacting protein 1 2.23052
LOC128966622 putative protein N-methyltransferase FAM86B2 2.22941
BYSL bystin-like 2.22912
ELMO3 engulfment and cell motility 3 2.22845
KIAA0930 KIAA0930 2.22263
SIRT5 sirtuin 5 2.22254
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.22239
N4BP2L1 NEDD4 binding protein 2-like 1 2.2196
ZNF202 zinc finger protein 202 2.21864
SLC38A4 solute carrier family 38, member 4 2.21772
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 2.21647
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 2.21646
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.2161
LGALS4 lectin, galactoside-binding, soluble, 4 2.21504
MAPK7 mitogen-activated protein kinase 7 2.21438
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.21425
RAP1B RAP1B, member of RAS oncogene family 2.21001
AKAP4 A kinase (PRKA) anchor protein 4 2.20985
CCL7 chemokine (C-C motif) ligand 7 2.20849
SWAP70 SWAP switching B-cell complex 70kDa subunit 2.20792
CTSF cathepsin F 2.20437
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 2.20375
DRC3 dynein regulatory complex subunit 3 2.20184
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.20163
CCNE2 cyclin E2 2.20078
NFE2 nuclear factor, erythroid 2 2.20055
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.19991
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 2.19967
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 2.19775
FGF5 fibroblast growth factor 5 2.19656
MOCS1 molybdenum cofactor synthesis 1 2.19611
AFM afamin 2.195
SMAD1 SMAD family member 1 2.19331
CPNE7 copine VII 2.19239
OLFM4 olfactomedin 4 2.19216
NOP53 NOP53 ribosome biogenesis factor 2.19195
RNF31 ring finger protein 31 2.19005
KANK3 KN motif and ankyrin repeat domains 3 2.18858
ANXA4 annexin A4 2.187
CXCL3 chemokine (C-X-C motif) ligand 3 2.18599
ZNF692 zinc finger protein 692 2.1844
PUM3 pumilio RNA binding family member 3 2.18297
PSG11 pregnancy specific beta-1-glycoprotein 11 2.18271
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 2.18133
NPIPA6 nuclear pore complex interacting protein family, member A6 2.18068
PRKD2 protein kinase D2 2.17778
IL7 interleukin 7 2.1767
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 2.17569
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.17376
RAB21 RAB21, member RAS oncogene family 2.173
FTCD formimidoyltransferase cyclodeaminase 2.1714
MYF5 myogenic factor 5 2.17111
SMIM40 small integral membrane protein 40 2.16676
SIRPA signal-regulatory protein alpha 2.16517
JUP junction plakoglobin 2.16447
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta 2.1614
TMPRSS3 transmembrane protease, serine 3 2.1611
POU2F3 POU class 2 homeobox 3 2.15892
IFT38 intraflagellar transport 38 2.1588
BHMT betaine--homocysteine S-methyltransferase 2.15879
ALAS1 5'-aminolevulinate synthase 1 2.15816
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2.15647
SYNJ2BP synaptojanin 2 binding protein 2.15551
CTNND1 catenin (cadherin-associated protein), delta 1 2.15345
UBQLN2 ubiquilin 2 2.15157
AMPD1 adenosine monophosphate deaminase 1 2.15008
CXCL11 chemokine (C-X-C motif) ligand 11 2.14984
RHOBTB1 Rho-related BTB domain containing 1 2.14852
ZNF362 zinc finger protein 362 2.14828
VPREB1 pre-B lymphocyte 1 2.14782
FLCN folliculin 2.14655
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.14357
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 2.14289
RAB3B RAB3B, member RAS oncogene family 2.14281
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.14244
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.14196
SOX18 SRY (sex determining region Y)-box 18 2.14194
UBQLN3 ubiquilin 3 2.13993
UPB1 ureidopropionase, beta 2.13866
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.13811
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.13783
ALX3 ALX homeobox 3 2.13448
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.13313
DENND2A DENN/MADD domain containing 2A 2.13154
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.13153
ZC2HC1A zinc finger, C2HC-type containing 1A 2.13118
NUAK2 NUAK family, SNF1-like kinase, 2 2.13079
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.13045
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.12992
PTPRT protein tyrosine phosphatase, receptor type, T 2.12981
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.12791
APOL5 apolipoprotein L, 5 2.1278
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.12522
BAX BCL2-associated X protein 2.12503
TSNAXIP1 translin-associated factor X interacting protein 1 2.12164
TSPAN4 tetraspanin 4 2.12097
FFAR3 free fatty acid receptor 3 2.12042
EXO5 exonuclease 5 2.12021
KREMEN2 kringle containing transmembrane protein 2 2.11724
CPA4 carboxypeptidase A4 2.11628
TESK1 testis-specific kinase 1 2.11611
RAB26 RAB26, member RAS oncogene family 2.11473
GJA8 gap junction protein, alpha 8, 50kDa 2.11186
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.10868
MZB1 marginal zone B and B1 cell-specific protein 2.10791
IL23A interleukin 23, alpha subunit p19 2.10712
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 2.10708
LHX1 LIM homeobox 1 2.10463
DEFA5 defensin, alpha 5, Paneth cell-specific 2.10416
KRT6B keratin 6B, type II 2.10253
FGF18 fibroblast growth factor 18 2.10201
MAB21L1 mab-21-like 1 (C. elegans) 2.09899
TRIM15 tripartite motif containing 15 2.09862
ANO2 anoctamin 2, calcium activated chloride channel 2.09768
OSGIN2 oxidative stress induced growth inhibitor family member 2 2.09766
BEST2 bestrophin 2 2.09675
CCL4 chemokine (C-C motif) ligand 4 2.09346
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 2.09342
DIPK1A divergent protein kinase domain 1A 2.09319
SCCPDH saccharopine dehydrogenase (putative) 2.09163
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.09083
CDHR2 cadherin-related family member 2 2.0896
FBLN2 fibulin 2 2.0885
CLDN14 claudin 14 2.08712
ZNF250 zinc finger protein 250 2.08711
CCDC51 coiled-coil domain containing 51 2.08528
CLCA1 chloride channel accessory 1 2.08417
MINPP1 multiple inositol-polyphosphate phosphatase 1 2.08288
CRYBA2 crystallin, beta A2 2.08095
EPAS1 endothelial PAS domain protein 1 2.07803
PRDM9 PR domain containing 9 2.07791
CTRC chymotrypsin C (caldecrin) 2.07537
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.07462
ERVMER34-1 endogenous retrovirus group MER34, member 1 2.07437
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 2.07334
PRTN3 proteinase 3 2.07211
STK38 serine/threonine kinase 38 2.0714
IRGQ immunity-related GTPase family, Q 2.07119
BRME1 break repair meiotic recombinase recruitment factor 1 2.07042
RXYLT1 ribitol xylosyltransferase 1 2.0697
DOC2B double C2-like domains, beta 2.06856
NHERF4 NHERF family PDZ scaffold protein 4 2.06813
MED9 mediator complex subunit 9 2.06655
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase 2.06512
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 2.06502
PTPRB protein tyrosine phosphatase, receptor type, B 2.06359
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.06327
ADIRF adipogenesis regulatory factor 2.0622
EMCN endomucin 2.0612
HTRA2 HtrA serine peptidase 2 2.06118
IQSEC1 IQ motif and Sec7 domain 1 2.06084
TMEM265 transmembrane protein 265 2.06052
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.06001
ZNF667 zinc finger protein 667 2.05914
IL1R1 interleukin 1 receptor, type I 2.05539
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 2.05274
A1CF APOBEC1 complementation factor 2.04943
ADAM2 ADAM metallopeptidase domain 2 2.04901
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 2.04881
EHD3 EH-domain containing 3 2.04828
KIF13A kinesin family member 13A 2.04827
FRMD4B FERM domain containing 4B 2.04805
MOB3B MOB kinase activator 3B 2.04781
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 2.0473
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 2.04543
PPP6R2 protein phosphatase 6, regulatory subunit 2 2.04466
CCL3L3 chemokine (C-C motif) ligand 3-like 3 2.0443
OSBPL3 oxysterol binding protein-like 3 2.04427
STX4 syntaxin 4 2.04414
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 2.04264
SLC38A2 solute carrier family 38, member 2 2.04197
TMEM40 transmembrane protein 40 2.0405
PROS1 protein S (alpha) 2.04042
CREB5 cAMP responsive element binding protein 5 2.03998
MAPK11 mitogen-activated protein kinase 11 2.03798
IL3 interleukin 3 2.03646
TMEM254 transmembrane protein 254 2.03641
FABP3 fatty acid binding protein 3, muscle and heart 2.03439
E2F1 E2F transcription factor 1 2.03427
IMPACT impact RWD domain protein 2.03398
EFCAB6 EF-hand calcium binding domain 6 2.03346
LAMA5 laminin, alpha 5 2.03288
ARHGAP22 Rho GTPase activating protein 22 2.03145
ZNF155 zinc finger protein 155 2.03125
PRAMEF10 PRAME family member 10 2.03094
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 2.0307
MYCT1 myc target 1 2.03002
PLEKHA6 pleckstrin homology domain containing, family A member 6 2.02958
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.02812
RNF123 ring finger protein 123 2.02801
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.02732
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 2.02628
H2AP H2A.P histone 2.02622
CRX cone-rod homeobox 2.02596
SDC4 syndecan 4 2.02536
CALCRL calcitonin receptor-like 2.02516
SYN3 synapsin III 2.02322
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like 2.0224
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 2.02071
BTBD7 BTB (POZ) domain containing 7 2.02006
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2.01967
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.01713
TM7SF3 transmembrane 7 superfamily member 3 2.01638
TERT telomerase reverse transcriptase 2.01621
MRPS10 mitochondrial ribosomal protein S10 2.01562
EFNB1 ephrin-B1 2.01399
TRIM46 tripartite motif containing 46 2.01313
ZNF440 zinc finger protein 440 2.0115
ATP11B ATPase, class VI, type 11B 2.01072
TCF20 transcription factor 20 (AR1) 2.00973
NKRF NFKB repressing factor 2.00873
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 2.00858
MUC1 mucin 1, cell surface associated 2.00814
FILIP1L filamin A interacting protein 1-like 2.00648
ANGPT2 angiopoietin 2 2.0057
ADAMDEC1 ADAM-like, decysin 1 2.0045
ITGA8 integrin, alpha 8 2.00203

decreased expression

Symbol Name Standardized Value
KIF20A kinesin family member 20A -8.00176
CCNB2 cyclin B2 -7.98444
CDC20 cell division cycle 20 -6.70901
KIF14 kinesin family member 14 -5.62235
CCNB1 cyclin B1 -5.57552
PSRC1 proline/serine-rich coiled-coil 1 -5.5258
PCCB propionyl CoA carboxylase, beta polypeptide -5.30881
PLK1 polo-like kinase 1 -4.96379
ANKRD10 ankyrin repeat domain 10 -4.88938
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -4.79862
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -4.51147
TRAPPC3 trafficking protein particle complex 3 -4.46717
NLRP2B NLR family pyrin domain containing 2B -4.43784
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -4.36405
BIRC5 baculoviral IAP repeat containing 5 -4.26091
DEPDC1 DEP domain containing 1 -4.18281
THAP11 THAP domain containing 11 -4.17819
CCNA2 cyclin A2 -4.14395
ARFIP2 ADP-ribosylation factor interacting protein 2 -4.12485
TOP2A topoisomerase (DNA) II alpha 170kDa -4.10905
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -4.0978
SESN1 sestrin 1 -3.88696
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -3.75597
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.56608
ANXA2 annexin A2 -3.55867
CRTAP cartilage associated protein -3.53343
MAPK13 mitogen-activated protein kinase 13 -3.5273
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.52417
LBR lamin B receptor -3.51683
UBE2S ubiquitin-conjugating enzyme E2S -3.49658
ETFB electron-transfer-flavoprotein, beta polypeptide -3.45368
CBR3 carbonyl reductase 3 -3.43703
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.43576
CENPA centromere protein A -3.42231
DDIT4 DNA-damage-inducible transcript 4 -3.39897
SLC35B1 solute carrier family 35, member B1 -3.38773
NRIP1 nuclear receptor interacting protein 1 -3.30756
GTF2A2 general transcription factor IIA, 2, 12kDa -3.2873
COTL1 coactosin-like F-actin binding protein 1 -3.27339
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -3.25043
RPA3 replication protein A3, 14kDa -3.24897
UBE2C ubiquitin-conjugating enzyme E2C -3.22227
PRC1 protein regulator of cytokinesis 1 -3.22111
NUSAP1 nucleolar and spindle associated protein 1 -3.21647
ZNF226 zinc finger protein 226 -3.19812
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.18302
CD151 CD151 molecule (Raph blood group) -3.12795
RNASE7 ribonuclease, RNase A family, 7 -3.10312
CDKN3 cyclin-dependent kinase inhibitor 3 -3.0936
SLC35F2 solute carrier family 35, member F2 -3.0919
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -3.08815
CKAP5 cytoskeleton associated protein 5 -3.08516
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -3.07007
HSPB1 heat shock 27kDa protein 1 -3.04991
EIF3I eukaryotic translation initiation factor 3, subunit I -3.03611
RIC8A RIC8 guanine nucleotide exchange factor A -3.02724
CISD1 CDGSH iron sulfur domain 1 -3.02273
LDHD lactate dehydrogenase D -2.99231
TACC3 transforming, acidic coiled-coil containing protein 3 -2.98128
PBK PDZ binding kinase -2.98035
CLTC clathrin, heavy chain (Hc) -2.97775
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.9408
TUBA4A tubulin, alpha 4a -2.92688
CENPN centromere protein N -2.89842
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -2.8835
ZNF274 zinc finger protein 274 -2.85322
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.83383
SLC25A46 solute carrier family 25, member 46 -2.81995
IST1 increased sodium tolerance 1 homolog (yeast) -2.81397
LRRC59 leucine rich repeat containing 59 -2.81229
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -2.81129
CTR9 CTR9, Paf1/RNA polymerase II complex component -2.80142
ANXA7 annexin A7 -2.79747
NEK2 NIMA-related kinase 2 -2.7849
CD81 CD81 molecule -2.77596
ADGRE5 adhesion G protein-coupled receptor E5 -2.74027
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.73897
CASC3 cancer susceptibility candidate 3 -2.72262
OXA1L oxidase (cytochrome c) assembly 1-like -2.71081
SEC61G Sec61 gamma subunit -2.7097
CDCA3 cell division cycle associated 3 -2.69272
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.68134
SMC1A structural maintenance of chromosomes 1A -2.65268
PHGDH phosphoglycerate dehydrogenase -2.65027
MRPL12 mitochondrial ribosomal protein L12 -2.64694
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -2.63925
STMN1 stathmin 1 -2.63631
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa -2.63367
GOLT1B golgi transport 1B -2.61673
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -2.61132
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.60287
COMMD1 copper metabolism (Murr1) domain containing 1 -2.5979
COPB1 coatomer protein complex, subunit beta 1 -2.59361
PTTG1 pituitary tumor-transforming 1 -2.5889
GLRX glutaredoxin (thioltransferase) -2.58252
ECD ecdysoneless homolog (Drosophila) -2.57905
CDK7 cyclin-dependent kinase 7 -2.57829
TPX2 TPX2, microtubule-associated -2.57642
MRPS16 mitochondrial ribosomal protein S16 -2.57009
ITCH itchy E3 ubiquitin protein ligase -2.56104
OLA1 Obg-like ATPase 1 -2.55455
NT5DC2 5'-nucleotidase domain containing 2 -2.55413
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -2.5496
TRIP12 thyroid hormone receptor interactor 12 -2.54875
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -2.54215
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.52466
EAPP E2F-associated phosphoprotein -2.51826
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.5069
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -2.49584
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.49516
UBP1 upstream binding protein 1 (LBP-1a) -2.4873
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -2.48344
RPL18 ribosomal protein L18 -2.48053
CARS1 cysteinyl-tRNA synthetase 1 -2.47922
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.47416
TTK TTK protein kinase -2.46952
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor -2.45711
CDK1 cyclin-dependent kinase 1 -2.45054
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.44627
PEPD peptidase D -2.44079
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.4318
UBC ubiquitin C -2.43128
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.42996
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -2.42876
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.42307
HSF2 heat shock transcription factor 2 -2.41242
GEMIN2 gem (nuclear organelle) associated protein 2 -2.4113
RACGAP1 Rac GTPase activating protein 1 -2.41017
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -2.40536
FKBP3 FK506 binding protein 3, 25kDa -2.40145
NAP1L4 nucleosome assembly protein 1-like 4 -2.3976
AURKA aurora kinase A -2.38921
OTUD3 OTU deubiquitinase 3 -2.38516
ATP5MC3 ATP synthase membrane subunit c locus 3 -2.37931
FOXM1 forkhead box M1 -2.37753
TOP2B topoisomerase (DNA) II beta 180kDa -2.37582
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -2.37027
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.36571
PDCD5 programmed cell death 5 -2.36559
COPZ1 coatomer protein complex, subunit zeta 1 -2.35842
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -2.35565
KIF2C kinesin family member 2C -2.34358
CST3 cystatin C -2.34222
ACTG1 actin gamma 1 -2.34121
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.33899
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.33776
KAT7 K(lysine) acetyltransferase 7 -2.33585
CGRRF1 cell growth regulator with ring finger domain 1 -2.33371
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha -2.32895
MFN1 mitofusin 1 -2.32474
CMC2 C-x(9)-C motif containing 2 -2.32178
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -2.32172
GRB14 growth factor receptor-bound protein 14 -2.32122
SPAG5 sperm associated antigen 5 -2.32026
TMCO1 transmembrane and coiled-coil domains 1 -2.31755
ADI1 acireductone dioxygenase 1 -2.31736
RPS12 ribosomal protein S12 -2.31552
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.31201
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -2.31196
FAM168B family with sequence similarity 168, member B -2.30833
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.30734
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.30656
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.30588
CEP55 centrosomal protein 55kDa -2.30089
SPC25 SPC25, NDC80 kinetochore complex component -2.29699
SELENOF selenoprotein F -2.29088
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.28557
LASP1 LIM and SH3 protein 1 -2.28494
DBF4 DBF4 zinc finger -2.27672
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -2.27565
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.274
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.26457
DCPH1 damage control phosphatase 1 -2.26312
TPD52L1 tumor protein D52-like 1 -2.26024
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.2602
NFS1 NFS1 cysteine desulfurase -2.25772
SNUPN snurportin 1 -2.25557
EGLN1 egl-9 family hypoxia-inducible factor 1 -2.25509
PPID peptidylprolyl isomerase D -2.25345
PFN1 profilin 1 -2.24956
ACP6 acid phosphatase 6, lysophosphatidic -2.24862
SF3B5 splicing factor 3b, subunit 5, 10kDa -2.24748
PGRMC1 progesterone receptor membrane component 1 -2.2454
RRM1 ribonucleotide reductase M1 -2.24433
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.24051
TAC4 tachykinin 4 (hemokinin) -2.23811
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -2.2381
ANAPC1 anaphase promoting complex subunit 1 -2.23753
TXNDC9 thioredoxin domain containing 9 -2.23686
BLVRA biliverdin reductase A -2.23621
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.23438
UBL5 ubiquitin-like 5 -2.23261
RNPEP arginyl aminopeptidase (aminopeptidase B) -2.22847
ELAVL1 ELAV like RNA binding protein 1 -2.22293
PRUNE1 prune exopolyphosphatase 1 -2.22213
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 -2.21542
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -2.21309
ECI2 enoyl-CoA delta isomerase 2 -2.21297
SLIRP SRA stem-loop interacting RNA binding protein -2.21291
RTRAF RNA transcription, translation and transport factor -2.20883
TLK1 tousled-like kinase 1 -2.20509
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.20242
POTEF POTE ankyrin domain family, member F -2.19831
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -2.19757
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.19557
THRAP3 thyroid hormone receptor associated protein 3 -2.19511
RPS4X ribosomal protein S4, X-linked -2.19439
MRPL17 mitochondrial ribosomal protein L17 -2.19434
MLEC malectin -2.19409
ZNF211 zinc finger protein 211 -2.19022
RPS27 ribosomal protein S27 -2.19003
NPR2 natriuretic peptide receptor 2 -2.18963
RPL27A ribosomal protein L27a -2.18806
SUB1 SUB1 homolog (S. cerevisiae) -2.18562
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase -2.18358
RPS13 ribosomal protein S13 -2.18225
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 -2.18092
BMAL1 basic helix-loop-helix ARNT like 1 -2.17702
KRT7 keratin 7, type II -2.16955
RPS5 ribosomal protein S5 -2.1672
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.16678
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.16654
SEPTIN6 septin 6 -2.16523
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -2.16478
RPS10 ribosomal protein S10 -2.15805
ETV1 ets variant 1 -2.1568
RPS19 ribosomal protein S19 -2.15585
RPL8 ribosomal protein L8 -2.15029
TALDO1 transaldolase 1 -2.14535
RPL9 ribosomal protein L9 -2.14069
FASTKD5 FAST kinase domains 5 -2.1369
RAD51C RAD51 paralog C -2.13643
RAD23B RAD23 homolog B (S. cerevisiae) -2.13334
CHPT1 choline phosphotransferase 1 -2.1296
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.12234
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -2.11994
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -2.11955
MRPS2 mitochondrial ribosomal protein S2 -2.11669
KDM1A lysine (K)-specific demethylase 1A -2.1165
ZBED5 zinc finger, BED-type containing 5 -2.11113
HMGB2 high mobility group box 2 -2.10885
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -2.10642
SRP54 signal recognition particle 54kDa -2.10011
HDDC2 HD domain containing 2 -2.09854
ASB7 ankyrin repeat and SOCS box containing 7 -2.09715
KRT10 keratin 10, type I -2.09552
FRS2 fibroblast growth factor receptor substrate 2 -2.09248
SERP1 stress-associated endoplasmic reticulum protein 1 -2.09233
RPL27 ribosomal protein L27 -2.09197
NCOA6 nuclear receptor coactivator 6 -2.08983
CDC25C cell division cycle 25C -2.08587
RPS26 ribosomal protein S26 -2.08142
PUF60 poly-U binding splicing factor 60KDa -2.0789
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -2.07642
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.07389
RETREG3 reticulophagy regulator family member 3 -2.06876
PPIA peptidylprolyl isomerase A (cyclophilin A) -2.06864
HDAC3 histone deacetylase 3 -2.06796
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -2.0672
TMSB4X thymosin beta 4, X-linked -2.06337
GOLM1 golgi membrane protein 1 -2.0622
PGAM4 phosphoglycerate mutase family member 4 -2.05073
RBBP7 retinoblastoma binding protein 7 -2.04923
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.0492
CCDC59 coiled-coil domain containing 59 -2.0468
PGM1 phosphoglucomutase 1 -2.04666
GET1 guided entry of tail-anchored proteins factor 1 -2.04629
GALE UDP-galactose-4-epimerase -2.0456
PINK1 PTEN induced putative kinase 1 -2.04448
ARGLU1 arginine and glutamate rich 1 -2.03911
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.0368
EMC8 ER membrane protein complex subunit 8 -2.03521
NCBP2 nuclear cap binding protein subunit 2, 20kDa -2.03442
KIF1B kinesin family member 1B -2.03431
NIPSNAP2 nipsnap homolog 2 -2.03241
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.02728
FPGS folylpolyglutamate synthase -2.02557
OAZ1 ornithine decarboxylase antizyme 1 -2.02547
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.02068
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.01986
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -2.01794
YME1L1 YME1-like 1 ATPase -2.01736
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.01727
FAM53C family with sequence similarity 53, member C -2.01701
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -2.01699
PRKCD protein kinase C, delta -2.01402
MED23 mediator complex subunit 23 -2.01323
AP2M1 adaptor-related protein complex 2, mu 1 subunit -2.01256
LDLRAP1 low density lipoprotein receptor adaptor protein 1 -2.01247
RHOB ras homolog family member B -2.00703
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.00479
CPNE3 copine III -2.00338
RPS18 ribosomal protein S18 -2.00201
MRPL23 mitochondrial ribosomal protein L23 -2.00165
CCR7 chemokine (C-C motif) receptor 7 -2.00035