CRCGN016_MCF10A.TP53.M_24H:K17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetaldehyde 34.6 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:K17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TCTN1 tectonic family member 1 4.36706
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.29079
KDM5D lysine (K)-specific demethylase 5D 4.25449
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.21259
IDE insulin-degrading enzyme 4.12733
STIMATE STIM activating enhancer 3.88122
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.47991
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.30026
CADM1 cell adhesion molecule 1 3.16278
USP9Y ubiquitin specific peptidase 9, Y-linked 2.92824
ALDOC aldolase C, fructose-bisphosphate 2.65904
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.56201
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.44655
SFTPB surfactant protein B 2.39914
NLGN4Y neuroligin 4, Y-linked 2.39727
ADGRE2 adhesion G protein-coupled receptor E2 2.39664
MERTK MER proto-oncogene, tyrosine kinase 2.32645
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 2.2878
ATF7IP2 activating transcription factor 7 interacting protein 2 2.25833
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.25591
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.24084
LYN LYN proto-oncogene, Src family tyrosine kinase 2.22681
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 2.16303
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.15896
ZFY zinc finger protein, Y-linked 2.158
GALK1 galactokinase 1 2.15035
SATB1 SATB homeobox 1 2.0906
TCTN3 tectonic family member 3 2.08884
APH1B APH1B gamma secretase subunit 2.08465
PXMP4 peroxisomal membrane protein 4, 24kDa 2.05194
LAG3 lymphocyte-activation gene 3 2.05051
SOD1 superoxide dismutase 1, soluble 2.04645
FGGY FGGY carbohydrate kinase domain containing 2.01355

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.26362
CHMP4B charged multivesicular body protein 4B -5.13546
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.96974
HEATR1 HEAT repeat containing 1 -3.97126
ETFB electron-transfer-flavoprotein, beta polypeptide -3.71423
KRT14 keratin 14, type I -2.94279
COTL1 coactosin-like F-actin binding protein 1 -2.87107
ACO2 aconitase 2, mitochondrial -2.60287
C1QBP complement component 1, q subcomponent binding protein -2.56525
PRCP prolylcarboxypeptidase (angiotensinase C) -2.45538
OARD1 O-acyl-ADP-ribose deacylase 1 -2.42346
SMC1A structural maintenance of chromosomes 1A -2.4135
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.34987
BASP1 brain abundant, membrane attached signal protein 1 -2.33053
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 -2.2299
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.17704
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.11303
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -2.09987
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.08166
GAR1 GAR1 ribonucleoprotein -2.07412
TFPI2 tissue factor pathway inhibitor 2 -2.06709
TWIST1 twist family bHLH transcription factor 1 -2.04487
TMEM164 transmembrane protein 164 -2.02629
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 -2.00998