CRCGN016_MCF10A.TP53.M_24H:K20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cresol 33.23 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:K20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 4.74707
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.58189
SPAG4 sperm associated antigen 4 4.53868
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.3953
MAMLD1 mastermind-like domain containing 1 4.37867
STAP2 signal transducing adaptor family member 2 4.06579
PDLIM1 PDZ and LIM domain 1 3.87414
PRKCH protein kinase C, eta 3.66102
TIAM1 T-cell lymphoma invasion and metastasis 1 3.646
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 3.56334
PFKL phosphofructokinase, liver 3.14937
WIF1 WNT inhibitory factor 1 3.14762
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 3.06208
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.91503
PTTG1IP pituitary tumor-transforming 1 interacting protein 2.65981
MATN2 matrilin 2 2.48717
BIRC2 baculoviral IAP repeat containing 2 2.41177
PRB4 proline-rich protein BstNI subfamily 4 2.39356
TP53RK TP53 regulating kinase 2.31793
SLC41A3 solute carrier family 41, member 3 2.30773
RXYLT1 ribitol xylosyltransferase 1 2.27956
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.27202
PPCS phosphopantothenoylcysteine synthetase 2.27089
FZD7 frizzled class receptor 7 2.25938
RBBP7 retinoblastoma binding protein 7 2.23491
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 2.162
BLM Bloom syndrome, RecQ helicase-like 2.15748
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.1498
PRB2 proline-rich protein BstNI subfamily 2 2.14154
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.13652
ICOS inducible T-cell co-stimulator 2.13144
ZBTB24 zinc finger and BTB domain containing 24 2.12656
VTA1 vesicle (multivesicular body) trafficking 1 2.12654
UNC119 unc-119 homolog (C. elegans) 2.10546
TLCD3A TLC domain containing 3A 2.07748
MACROH2A2 macroH2A.2 histone 2.07342
NSG2 neuronal vesicle trafficking associated 2 2.06301
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.0551
EGLN1 egl-9 family hypoxia-inducible factor 1 2.04488
EEF1B2 eukaryotic translation elongation factor 1 beta 2 2.03452

decreased expression

Symbol Name Standardized Value
SGK1 serum/glucocorticoid regulated kinase 1 -4.66808
CDC25B cell division cycle 25B -4.61624
PARP2 poly (ADP-ribose) polymerase 2 -4.39783
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -4.39764
MRPS2 mitochondrial ribosomal protein S2 -4.18038
KIF20A kinesin family member 20A -3.88652
MSMO1 methylsterol monooxygenase 1 -3.78615
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -3.73896
PAEP progestagen-associated endometrial protein -3.23792
SCYL3 SCY1-like 3 (S. cerevisiae) -3.10414
TRIB3 tribbles pseudokinase 3 -2.8913
STK25 serine/threonine kinase 25 -2.88941
METTL17 methyltransferase like 17 -2.87118
GDF15 growth differentiation factor 15 -2.77615
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.66924
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -2.6144
FABP4 fatty acid binding protein 4, adipocyte -2.46974
CORO1A coronin, actin binding protein, 1A -2.4628
METTL3 methyltransferase like 3 -2.35564
ANAPC2 anaphase promoting complex subunit 2 -2.32171
DENND4B DENN/MADD domain containing 4B -2.27178
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -2.10306
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 -2.09423
KITLG KIT ligand -2.06149
ADAR adenosine deaminase, RNA-specific -2.04233
RNF31 ring finger protein 31 -2.02677
TEP1 telomerase-associated protein 1 -2.003
TLN1 talin 1 -2.00284