CRCGN016_MCF10A.TP53.M_24H:K22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description furosemide 97.78 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

24 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:K22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 4.48204
ZNF586 zinc finger protein 586 4.28208
SPAG4 sperm associated antigen 4 4.20299
WFS1 Wolfram syndrome 1 (wolframin) 3.08142
STX1A syntaxin 1A (brain) 2.96317
TSPAN6 tetraspanin 6 2.72049
CNRIP1 cannabinoid receptor interacting protein 1 2.47511
TSKU tsukushi, small leucine rich proteoglycan 2.33748
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.241
MAP7 microtubule-associated protein 7 2.17644
H1-10 H1.10 linker histone 2.00298

decreased expression

Symbol Name Standardized Value
TXNDC9 thioredoxin domain containing 9 -4.35079
DSG2 desmoglein 2 -4.17258
TSPAN4 tetraspanin 4 -3.7144
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.83097
INTS11 integrator complex subunit 11 -2.46309
RAD51C RAD51 paralog C -2.44231
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.35307
MT1X metallothionein 1X -2.27801
NOSIP nitric oxide synthase interacting protein -2.26304
GRN granulin -2.20518
HEATR1 HEAT repeat containing 1 -2.18794
CLIC4 chloride intracellular channel 4 -2.05558
EIF5B eukaryotic translation initiation factor 5B -2.02702