CRCGN016_MCF10A.TP53.M_24H:K23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description furosemide 32.59 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:K23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 3.40204
SNX11 sorting nexin 11 3.02047
C2CD2 C2 calcium-dependent domain containing 2 2.98532
PNKP polynucleotide kinase 3'-phosphatase 2.93745
PPARG peroxisome proliferator-activated receptor gamma 2.45858
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 2.3202
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.23914
F8 coagulation factor VIII, procoagulant component 2.16787
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 2.0143

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.11019
TERF2IP telomeric repeat binding factor 2, interacting protein -4.07062
CDC25B cell division cycle 25B -3.88161
CDC20 cell division cycle 20 -3.65568
MT1X metallothionein 1X -3.37933
FASTKD5 FAST kinase domains 5 -3.36195
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -3.31763
LYPLA1 lysophospholipase I -3.0398
CCNB1 cyclin B1 -2.94305
NPDC1 neural proliferation, differentiation and control, 1 -2.69244
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.67308
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.6445
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.6085
VDAC1 voltage-dependent anion channel 1 -2.57655
PFN1 profilin 1 -2.487
KRT14 keratin 14, type I -2.32577
PAX6 paired box 6 -2.29691
MRPL15 mitochondrial ribosomal protein L15 -2.18591
EXOSC4 exosome component 4 -2.05377
CAB39 calcium binding protein 39 -2.01877
IL1A interleukin 1, alpha -2.01606