CRCGN016_MCF10A.TP53.M_24H:L01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sorbic-acid 99.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:L01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MEF2C myocyte enhancer factor 2C 5.20594
SSBP2 single-stranded DNA binding protein 2 5.17756
FGFR4 fibroblast growth factor receptor 4 4.11352
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.82313
MTA2 metastasis associated 1 family, member 2 2.71557
MDM4 MDM4, p53 regulator 2.57793
RBBP5 retinoblastoma binding protein 5 2.52912
ZBTB35 zinc finger and BTB domain containing 35 2.45204
TNNI1 troponin I type 1 (skeletal, slow) 2.39535
MYL1 myosin, light chain 1, alkali; skeletal, fast 2.2845
FKBP14 FK506 binding protein 14, 22 kDa 2.28149
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.2373
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.20007
MYBPH myosin binding protein H 2.19743
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.16624
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.14253
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.13738
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.13258
KLHL41 kelch-like family member 41 2.11889
MYOT myotilin 2.04
DNTT DNA nucleotidylexotransferase 2.02978

decreased expression

Symbol Name Standardized Value
TSPAN4 tetraspanin 4 -3.57064
TES testin LIM domain protein -3.53024
BASP1 brain abundant, membrane attached signal protein 1 -3.26326
NUP85 nucleoporin 85kDa -3.25599
KCTD2 potassium channel tetramerization domain containing 2 -2.66263
THAP11 THAP domain containing 11 -2.56351
MRPL58 mitochondrial ribosomal protein L58 -2.56335
TMEM94 transmembrane protein 94 -2.3216
KRT14 keratin 14, type I -2.26391
CBR3 carbonyl reductase 3 -2.08072
CD8A CD8a molecule -2.04793