CRCGN016_MCF10A.TP53.M_24H:L02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sorbic-acid 33.1 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:L02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 3.47344
PECR peroxisomal trans-2-enoyl-CoA reductase 3.40168
CNRIP1 cannabinoid receptor interacting protein 1 3.26295
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 2.6585
SOCS2 suppressor of cytokine signaling 2 2.63758
ZNF395 zinc finger protein 395 2.44742
SNAP25 synaptosomal-associated protein, 25kDa 2.34717
WDR7 WD repeat domain 7 2.29884
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.28229
FAIM Fas apoptotic inhibitory molecule 2.20598
PNLIPRP2 pancreatic lipase-related protein 2 2.19861
GCG glucagon 2.14244
CADM1 cell adhesion molecule 1 2.13769
TUBA3E tubulin, alpha 3e 2.10542
MRPS18C mitochondrial ribosomal protein S18C 2.10117
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.06758
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 2.02018
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 2.01527

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -5.51433
CHMP4B charged multivesicular body protein 4B -4.8074
MSN moesin -3.8409
IFRD2 interferon-related developmental regulator 2 -3.32168
RPA3 replication protein A3, 14kDa -3.31785
PCNA proliferating cell nuclear antigen -2.93057
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.84002
UFM1 ubiquitin-fold modifier 1 -2.73304
TMEM115 transmembrane protein 115 -2.62925
SQSTM1 sequestosome 1 -2.48022
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -2.43375
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -2.41035
CDC20 cell division cycle 20 -2.25591
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough -2.17129
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -2.0774
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -2.04408
UBE2A ubiquitin-conjugating enzyme E2A -2.01668
MT1X metallothionein 1X -2.01177
MSH5 mutS homolog 5 -2.00699