CRCGN016_MCF10A.TP53.M_24H:L03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sorbic-acid 11.03 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:L03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNL4B thioredoxin-like 4B 4.83923
TGFB3 transforming growth factor, beta 3 4.71363
SNAP25 synaptosomal-associated protein, 25kDa 4.38589
RPL39L ribosomal protein L39-like 4.21517
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.54284
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.71283
ATG7 autophagy related 7 2.52886
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 2.52038
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 2.35325
NEFH neurofilament, heavy polypeptide 2.27163
RGS18 regulator of G-protein signaling 18 2.23611
FZD1 frizzled class receptor 1 2.19109
GNG4 guanine nucleotide binding protein (G protein), gamma 4 2.1496
BEX2 brain expressed X-linked 2 2.14731
BCCIP BRCA2 and CDKN1A interacting protein 2.1334
CALCRL calcitonin receptor-like 2.11676
MEIS2 Meis homeobox 2 2.10283
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.08463
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 2.08439
FANCG Fanconi anemia, complementation group G 2.07576
IL9 interleukin 9 2.03836
PDE8B phosphodiesterase 8B 2.03801
SNAI2 snail family zinc finger 2 2.03075
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 2.02419
ANKEF1 ankyrin repeat and EF-hand domain containing 1 2.02254

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.56617
RNF167 ring finger protein 167 -4.55047
PMM2 phosphomannomutase 2 -4.02891
NGRN neugrin, neurite outgrowth associated -3.83703
GNAS GNAS complex locus -3.8284
MSN moesin -3.60449
ATP5F1E ATP synthase F1 subunit epsilon -3.49747
PFN1 profilin 1 -3.3798
PCCB propionyl CoA carboxylase, beta polypeptide -3.2626
GDF15 growth differentiation factor 15 -2.9564
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -2.85246
SRP9 signal recognition particle 9kDa -2.82424
H3-3A H3.3 histone A -2.82212
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.76724
HAT1 histone acetyltransferase 1 -2.53421
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.47977
RPL38 ribosomal protein L38 -2.47636
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -2.43245
THNSL2 threonine synthase-like 2 (S. cerevisiae) -2.31496
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa -2.30604
SNRPG small nuclear ribonucleoprotein polypeptide G -2.2781
LAGE3 L antigen family, member 3 -2.27005
ASL argininosuccinate lyase -2.25466
RPN2 ribophorin II -2.23212
RPL34 ribosomal protein L34 -2.19985
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.19288
MSMO1 methylsterol monooxygenase 1 -2.1762
ATRAID all-trans retinoic acid-induced differentiation factor -2.1373
ATP5ME ATP synthase membrane subunit e -2.12395
GTF2H5 general transcription factor IIH, polypeptide 5 -2.08092
SSBP1 single-stranded DNA binding protein 1, mitochondrial -2.07887
COXFA4 cytochrome c oxidase associated subunit FA4 -2.07727
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) -2.05964
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -2.05632
ATP5IF1 ATP synthase inhibitory factor subunit 1 -2.04524
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -2.04424
RPLP2 ribosomal protein, large, P2 -2.02957
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -2.02044
PHYH phytanoyl-CoA 2-hydroxylase -2.01106
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.01003