CRCGN016_MCF10A.TP53.M_24H:L08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fd & c blue no. 2 33.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:L08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.0618
FGFR4 fibroblast growth factor receptor 4 4.63997
CCDC92 coiled-coil domain containing 92 4.27962
SNAP25 synaptosomal-associated protein, 25kDa 2.92977
ACAA1 acetyl-CoA acyltransferase 1 2.58982
NNT nicotinamide nucleotide transhydrogenase 2.50657
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 2.30535
MORF4L2 mortality factor 4 like 2 2.26913
RNF123 ring finger protein 123 2.24989
CBR4 carbonyl reductase 4 2.17861
APOA2 apolipoprotein A-II 2.17619
REXO5 RNA exonuclease 5 2.17474
KIF5C kinesin family member 5C 2.17086
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.16447
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.11356
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 2.09359
TMEM50A transmembrane protein 50A 2.09078
SEC13 SEC13 homolog (S. cerevisiae) 2.04198
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 2.00992
INTS11 integrator complex subunit 11 2.00589

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.6319
KRT14 keratin 14, type I -7.50706
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.19319
PUF60 poly-U binding splicing factor 60KDa -5.02379
BID BH3 interacting domain death agonist -4.40683
RPA3 replication protein A3, 14kDa -4.26459
HEATR1 HEAT repeat containing 1 -3.8744
NAMPT nicotinamide phosphoribosyltransferase -3.69047
HAT1 histone acetyltransferase 1 -3.46575
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.37822
PPIC peptidylprolyl isomerase C (cyclophilin C) -3.17885
BCAP29 B-cell receptor-associated protein 29 -2.97619
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -2.81465
LTF lactotransferrin -2.68283
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.67411
TRIP6 thyroid hormone receptor interactor 6 -2.67369
COG5 component of oligomeric golgi complex 5 -2.66096
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.59158
SLC66A2 solute carrier family 66 member 2 -2.54574
NPDC1 neural proliferation, differentiation and control, 1 -2.54528
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -2.52608
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.45515
FASN fatty acid synthase -2.42671
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.38874
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.3476
ANKRD11 ankyrin repeat domain 11 -2.33267
CSTA cystatin A (stefin A) -2.30303
LY6E lymphocyte antigen 6 complex, locus E -2.24723
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase -2.24644
MB myoglobin -2.24322
ZC3H15 zinc finger CCCH-type containing 15 -2.23023
BTN2A1 butyrophilin, subfamily 2, member A1 -2.2129
DCK deoxycytidine kinase -2.19419
WTAP Wilms tumor 1 associated protein -2.14846
NINJ1 ninjurin 1 -2.12699
YME1L1 YME1-like 1 ATPase -2.1217
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.08498
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -2.07934
LAPTM5 lysosomal protein transmembrane 5 -2.05777
TRIB3 tribbles pseudokinase 3 -2.03715
HMGXB4 HMG box domain containing 4 -2.00294