CRCGN016_MCF10A.TP53.M_24H:L09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fd & c blue no. 2 11.09 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:L09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 4.07743
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.88586
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.61301
CRELD2 cysteine-rich with EGF-like domains 2 3.55873
SNAP25 synaptosomal-associated protein, 25kDa 2.93335
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.90447
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.72473
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.695
DENND1B DENN/MADD domain containing 1B 2.61314
SMIM40 small integral membrane protein 40 2.57015
UVRAG UV radiation resistance associated 2.53179
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.42665
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.41557
VSNL1 visinin-like 1 2.32944
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.27735
PLXNB2 plexin B2 2.22522
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.21373
RSF1 remodeling and spacing factor 1 2.05484
RBM41 RNA binding motif protein 41 2.01839
SH3GL2 SH3-domain GRB2-like 2 2.01261

decreased expression

Symbol Name Standardized Value
GOLT1B golgi transport 1B -4.09082
TEX10 testis expressed 10 -4.04266
MT1X metallothionein 1X -3.60646
CHMP4B charged multivesicular body protein 4B -3.41422
KRT14 keratin 14, type I -3.23778
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.63872
PSIP1 PC4 and SFRS1 interacting protein 1 -2.6005
PCCB propionyl CoA carboxylase, beta polypeptide -2.48623
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.3648
THAP11 THAP domain containing 11 -2.32688
CAB39 calcium binding protein 39 -2.30362
TRAPPC3 trafficking protein particle complex 3 -2.2828
INTS13 integrator complex subunit 13 -2.26653
TP53 tumor protein p53 -2.25991
SRFBP1 serum response factor binding protein 1 -2.03714