CRCGN016_MCF10A.TP53.M_24H:L12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disulfiram 11.09 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

27 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:L12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCP110 centriolar coiled coil protein 110kDa 7.48982
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.30796
ADGRE5 adhesion G protein-coupled receptor E5 5.20329
SNAP25 synaptosomal-associated protein, 25kDa 4.69354
STMN2 stathmin 2 2.86758
ABHD4 abhydrolase domain containing 4 2.75517
GPER1 G protein-coupled estrogen receptor 1 2.73248
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.71702
WIF1 WNT inhibitory factor 1 2.69226
NSG2 neuronal vesicle trafficking associated 2 2.60341
GDE1 glycerophosphodiester phosphodiesterase 1 2.53524
PPARG peroxisome proliferator-activated receptor gamma 2.30116
SNAP91 synaptosomal-associated protein, 91kDa 2.17066
CXCR4 chemokine (C-X-C motif) receptor 4 2.15585
PTGDS prostaglandin D2 synthase 21kDa (brain) 2.14841
SATB1 SATB homeobox 1 2.13573
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.12492
SV2B synaptic vesicle glycoprotein 2B 2.09647
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.08661
NEFM neurofilament, medium polypeptide 2.06313
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.04664
STXBP3 syntaxin binding protein 3 2.03602

decreased expression

Symbol Name Standardized Value
NLRP4 NLR family, pyrin domain containing 4 -4.42014
NOSIP nitric oxide synthase interacting protein -3.1032
ZFTA zinc finger translocation associated -2.51149
SGK1 serum/glucocorticoid regulated kinase 1 -2.47923
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.18028