CRCGN016_MCF10A.TP53.M_24H:L18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichloropropane 11.03 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

221 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:L18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TBX2 T-box 2 7.90685
HBA1 hemoglobin, alpha 1 4.67073
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 4.02169
PRKX protein kinase, X-linked 3.85925
HBB hemoglobin, beta 3.61163
FZD7 frizzled class receptor 7 3.57639
ANKRD49 ankyrin repeat domain 49 3.35376
OXSR1 oxidative stress responsive 1 3.03431
ZNF134 zinc finger protein 134 2.9776
PEX12 peroxisomal biogenesis factor 12 2.86606
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.85444
TLCD3A TLC domain containing 3A 2.84575
LIMD1 LIM domains containing 1 2.84249
RNMT RNA (guanine-7-) methyltransferase 2.79055
SCAF8 SR-related CTD-associated factor 8 2.76832
PRB4 proline-rich protein BstNI subfamily 4 2.75136
EPM2AIP1 EPM2A (laforin) interacting protein 1 2.74411
SLC38A6 solute carrier family 38, member 6 2.72718
ASF1A anti-silencing function 1A histone chaperone 2.69442
EAPP E2F-associated phosphoprotein 2.68893
FOXJ1 forkhead box J1 2.63863
MACIR macrophage immunometabolism regulator 2.62122
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent 2.61703
HLA-DRA major histocompatibility complex, class II, DR alpha 2.61509
SPA17 sperm autoantigenic protein 17 2.61335
SYNGAP1 synaptic Ras GTPase activating protein 1 2.61119
F8 coagulation factor VIII, procoagulant component 2.59067
EP400 E1A binding protein p400 2.58554
ADORA3 adenosine A3 receptor 2.56078
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.53601
ZNF556 zinc finger protein 556 2.5289
NSUN3 NOP2/Sun domain family, member 3 2.50845
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 2.49547
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 2.49252
PRX periaxin 2.48554
ASTE1 asteroid homolog 1 (Drosophila) 2.48137
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.47378
FGGY FGGY carbohydrate kinase domain containing 2.47097
ALDOC aldolase C, fructose-bisphosphate 2.46734
ZNF510 zinc finger protein 510 2.4623
NR1D2 nuclear receptor subfamily 1, group D, member 2 2.45699
CADM1 cell adhesion molecule 1 2.443
ZNF443 zinc finger protein 443 2.41326
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 2.41175
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 2.40852
PLCD1 phospholipase C, delta 1 2.39316
CHMP1B charged multivesicular body protein 1B 2.37207
SPAG4 sperm associated antigen 4 2.36537
CD40LG CD40 ligand 2.36335
NCK1 NCK adaptor protein 1 2.35474
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 2.35101
PPARG peroxisome proliferator-activated receptor gamma 2.34235
TESC tescalcin 2.3374
SRR serine racemase 2.32891
NRBF2 nuclear receptor binding factor 2 2.32525
DRC9 dynein regulatory complex subunit 9 2.32426
KIF5C kinesin family member 5C 2.32072
APH1B APH1B gamma secretase subunit 2.31192
ZC3H14 zinc finger CCCH-type containing 14 2.31127
CEND1 cell cycle exit and neuronal differentiation 1 2.3094
SRBD1 S1 RNA binding domain 1 2.30441
ETV4 ets variant 4 2.29229
ATRIP ATR interacting protein 2.2857
FKBP14 FK506 binding protein 14, 22 kDa 2.28466
SMIM41 small integral membrane protein 41 2.27946
SERF1A small EDRK-rich factor 1A (telomeric) 2.27878
PRKCH protein kinase C, eta 2.27679
ZNF124 zinc finger protein 124 2.2734
NPAT nuclear protein, ataxia-telangiectasia locus 2.27179
ZNF226 zinc finger protein 226 2.25836
ZNF222 zinc finger protein 222 2.25282
PIERCE1 piercer of microtubule wall 1 2.23452
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.23247
GMDS GDP-mannose 4,6-dehydratase 2.22986
PAQR6 progestin and adipoQ receptor family member VI 2.20778
RXYLT1 ribitol xylosyltransferase 1 2.19596
TSPAN1 tetraspanin 1 2.18836
ZNF195 zinc finger protein 195 2.1768
PER3 period circadian clock 3 2.17263
GK glycerol kinase 2.17197
CAV3 caveolin 3 2.15107
ACP6 acid phosphatase 6, lysophosphatidic 2.15088
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.1477
TLR4 toll-like receptor 4 2.14756
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.14185
ANKRD17 ankyrin repeat domain 17 2.13382
GPC3 glypican 3 2.13345
CTSO cathepsin O 2.13043
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.12532
FOXRED2 FAD-dependent oxidoreductase domain containing 2 2.12382
PCDHGA10 protocadherin gamma subfamily A, 10 2.11916
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.11897
TCEAL1 transcription elongation factor A (SII)-like 1 2.11713
ACYP2 acylphosphatase 2, muscle type 2.11621
GSTZ1 glutathione S-transferase zeta 1 2.1036
GIN1 gypsy retrotransposon integrase 1 2.10249
SERINC5 serine incorporator 5 2.10243
GRAMD1B GRAM domain containing 1B 2.09824
CA8 carbonic anhydrase VIII 2.08728
NTM neurotrimin 2.08606
NME5 NME/NM23 family member 5 2.08406
TOM1L2 target of myb1-like 2 (chicken) 2.08111
THAP1 THAP domain containing, apoptosis associated protein 1 2.07842
PDCD1 programmed cell death 1 2.0714
F8A2 coagulation factor VIII-associated 2 2.06948
COL6A3 collagen, type VI, alpha 3 2.06835
HCFC1 host cell factor C1 2.0676
TRIM66 tripartite motif containing 66 2.06581
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.0649
IFT46 intraflagellar transport 46 2.05682
UTRN utrophin 2.05423
PGCKA1 PDCD10 and GCKIII kinases associated 1 2.05219
ATF7IP2 activating transcription factor 7 interacting protein 2 2.04839
MPHOSPH9 M-phase phosphoprotein 9 2.04443
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 2.04327
TENT5A terminal nucleotidyltransferase 5A 2.04238
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.04174
DLEC1 deleted in lung and esophageal cancer 1 2.04169
CD5 CD5 molecule 2.04064
TMEM231 transmembrane protein 231 2.03936
ZBED5 zinc finger, BED-type containing 5 2.03448
CXCL2 chemokine (C-X-C motif) ligand 2 2.03385
PALB2 partner and localizer of BRCA2 2.03301
MYO5C myosin VC 2.03222
IL3RA interleukin 3 receptor, alpha (low affinity) 2.03087
TGIF1 TGFB-induced factor homeobox 1 2.02045
DNTT DNA nucleotidylexotransferase 2.01798
ATXN7L1 ataxin 7-like 1 2.0165
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 2.01484
RPH3A rabphilin 3A 2.00567
TBC1D5 TBC1 domain family, member 5 2.00362
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 2.00142
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 2.00057

decreased expression

Symbol Name Standardized Value
TNIP1 TNFAIP3 interacting protein 1 -5.97883
TES testin LIM domain protein -5.55987
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -5.18754
HAT1 histone acetyltransferase 1 -4.99082
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.71268
COTL1 coactosin-like F-actin binding protein 1 -4.62228
JMJD6 jumonji domain containing 6 -4.47736
CHIC2 cysteine-rich hydrophobic domain 2 -4.3843
TUBA4A tubulin, alpha 4a -4.00162
CAB39 calcium binding protein 39 -3.93422
GADD45B growth arrest and DNA-damage-inducible, beta -3.70804
KRT14 keratin 14, type I -3.60075
RPL38 ribosomal protein L38 -3.33725
ARL2 ADP-ribosylation factor-like 2 -3.32707
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.29896
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.28886
EIF3L eukaryotic translation initiation factor 3, subunit L -3.25642
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -3.13866
MXRA7 matrix-remodelling associated 7 -3.12528
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.10586
IGFBP7 insulin-like growth factor binding protein 7 -2.96669
SARS1 seryl-tRNA synthetase 1 -2.94506
USP3 ubiquitin specific peptidase 3 -2.89704
NOP53 NOP53 ribosome biogenesis factor -2.8338
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.82558
RPL10A ribosomal protein L10a -2.8148
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.79019
RPS5 ribosomal protein S5 -2.76662
HOXA5 homeobox A5 -2.73392
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -2.63778
RPL19 ribosomal protein L19 -2.62023
STAT1 signal transducer and activator of transcription 1, 91kDa -2.58074
RPLP2 ribosomal protein, large, P2 -2.56152
GPR18 G protein-coupled receptor 18 -2.53065
CYB5R3 cytochrome b5 reductase 3 -2.4868
ISCU iron-sulfur cluster assembly enzyme -2.46028
LINC02762 long intergenic non-protein coding RNA 2762 -2.45042
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.44656
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -2.42477
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.42345
CCDC69 coiled-coil domain containing 69 -2.41669
NFE2L1 nuclear factor, erythroid 2-like 1 -2.39355
RPL18A ribosomal protein L18a -2.37107
FSTL1 follistatin-like 1 -2.36699
BASP1 brain abundant, membrane attached signal protein 1 -2.3582
RHBDF2 rhomboid 5 homolog 2 (Drosophila) -2.30102
CS citrate synthase -2.28761
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -2.28708
MSMO1 methylsterol monooxygenase 1 -2.26513
RPL3 ribosomal protein L3 -2.23441
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -2.23027
NUAK2 NUAK family, SNF1-like kinase, 2 -2.22789
RPL18 ribosomal protein L18 -2.20772
RPL4 ribosomal protein L4 -2.1918
PFKM phosphofructokinase, muscle -2.18872
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.18125
HLA-E major histocompatibility complex, class I, E -2.16919
IER5 immediate early response 5 -2.15482
MT1X metallothionein 1X -2.14243
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.14171
MCM6 minichromosome maintenance complex component 6 -2.13699
ATP5F1E ATP synthase F1 subunit epsilon -2.12031
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.11623
COA3 cytochrome c oxidase assembly factor 3 -2.11309
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.10836
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.10473
MRPL33 mitochondrial ribosomal protein L33 -2.10327
GATAD2A GATA zinc finger domain containing 2A -2.09959
SEC62 SEC62 homolog (S. cerevisiae) -2.09633
RPL29 ribosomal protein L29 -2.09335
RARS1 arginyl-tRNA synthetase 1 -2.08983
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -2.08918
ATP5PD ATP synthase peripheral stalk subunit d -2.08877
RPL36A ribosomal protein L36a -2.06858
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.0589
CCDC51 coiled-coil domain containing 51 -2.0526
S100A14 S100 calcium binding protein A14 -2.0477
RND3 Rho family GTPase 3 -2.04699
MRPS2 mitochondrial ribosomal protein S2 -2.03971
COX6C cytochrome c oxidase subunit VIc -2.03885
IRF8 interferon regulatory factor 8 -2.03032
THAP4 THAP domain containing 4 -2.02781
ARHGAP8 Rho GTPase activating protein 8 -2.02452
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.02088
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 -2.01959
TM9SF3 transmembrane 9 superfamily member 3 -2.01507
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.01427
SCRIB scribbled planar cell polarity protein -2.00157