CRCGN016_MCF10A.TP53.M_24H:L19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description atrazine 99.97 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

116 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:L19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.51473
HMOX1 heme oxygenase 1 5.37353
MAMLD1 mastermind-like domain containing 1 4.943
UBQLN2 ubiquilin 2 4.42333
FGFR4 fibroblast growth factor receptor 4 3.41611
AGR2 anterior gradient 2 3.04695
PEX12 peroxisomal biogenesis factor 12 3.03884
ENOSF1 enolase superfamily member 1 2.73887
CDK19 cyclin-dependent kinase 19 2.61419
PRPS2 phosphoribosyl pyrophosphate synthetase 2 2.57735
PGK1 phosphoglycerate kinase 1 2.57648
WNT2 wingless-type MMTV integration site family member 2 2.55839
TRIM24 tripartite motif containing 24 2.49609
MYO9A myosin IXA 2.44767
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.43697
RBBP7 retinoblastoma binding protein 7 2.36458
MAGEA12 melanoma antigen family A12 2.3216
ZFYVE21 zinc finger, FYVE domain containing 21 2.29817
LOC100533997 MAGEA10-MAGEA5 readthrough 2.27994
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.27903
TFB1M transcription factor B1, mitochondrial 2.2691
CD302 CD302 molecule 2.26342
ANKMY2 ankyrin repeat and MYND domain containing 2 2.25183
SATB1 SATB homeobox 1 2.2403
ZBTB38 zinc finger and BTB domain containing 38 2.21165
CRTC3 CREB regulated transcription coactivator 3 2.20619
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 2.19372
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 2.19311
MAGEA6 melanoma antigen family A6 2.1692
CCSER2 coiled-coil serine-rich protein 2 2.15492
RANGRF RAN guanine nucleotide release factor 2.13267
S100P S100 calcium binding protein P 2.12929
TTC19 tetratricopeptide repeat domain 19 2.12212
FER fer (fps/fes related) tyrosine kinase 2.12041
FOXC1 forkhead box C1 2.09951
IPP intracisternal A particle-promoted polypeptide 2.0905
F8 coagulation factor VIII, procoagulant component 2.08106
MRPL34 mitochondrial ribosomal protein L34 2.07729
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.06749
NR3C2 nuclear receptor subfamily 3, group C, member 2 2.06555
NUBPL nucleotide binding protein-like 2.06368
SERF1A small EDRK-rich factor 1A (telomeric) 2.06262
LTBP1 latent transforming growth factor beta binding protein 1 2.05076
MAGEA2B melanoma antigen family A2B 2.04917
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 2.04721
COQ8A coenzyme Q8A 2.04424
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.02243
TUBGCP4 tubulin, gamma complex associated protein 4 2.01979
PIR pirin (iron-binding nuclear protein) 2.01706
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 2.01074
RPL18 ribosomal protein L18 2.00234

decreased expression

Symbol Name Standardized Value
BASP1 brain abundant, membrane attached signal protein 1 -6.0039
KIF14 kinesin family member 14 -4.88113
TUBA4A tubulin, alpha 4a -4.81688
GOLT1B golgi transport 1B -4.50199
TXNDC9 thioredoxin domain containing 9 -4.45191
TRAPPC3 trafficking protein particle complex 3 -3.96105
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.85674
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.78096
COTL1 coactosin-like F-actin binding protein 1 -3.77069
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.51016
TMEM127 transmembrane protein 127 -3.12344
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.99601
TSSC4 tumor suppressing subtransferable candidate 4 -2.87678
KCNK12 potassium channel, two pore domain subfamily K, member 12 -2.77321
ZFYVE26 zinc finger, FYVE domain containing 26 -2.75742
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.62903
RBM38 RNA binding motif protein 38 -2.56857
RECQL RecQ helicase-like -2.56469
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -2.47492
PANX1 pannexin 1 -2.47029
MT1X metallothionein 1X -2.46709
INTS13 integrator complex subunit 13 -2.42574
CDC73 cell division cycle 73 -2.41201
PRR36 proline rich 36 -2.33043
ZDHHC13 zinc finger, DHHC-type containing 13 -2.32608
STK25 serine/threonine kinase 25 -2.31732
DOK3 docking protein 3 -2.31028
DNA2 DNA replication helicase/nuclease 2 -2.2949
RAI14 retinoic acid induced 14 -2.29426
SLC12A9 solute carrier family 12, member 9 -2.26717
COL8A2 collagen, type VIII, alpha 2 -2.25917
LMAN2L lectin, mannose-binding 2-like -2.24396
UBIAD1 UbiA prenyltransferase domain containing 1 -2.238
TBC1D17 TBC1 domain family, member 17 -2.22142
ZBTB48 zinc finger and BTB domain containing 48 -2.21707
ANAPC2 anaphase promoting complex subunit 2 -2.20065
RAD51AP1 RAD51 associated protein 1 -2.18584
MAP7D1 MAP7 domain containing 1 -2.18409
H2AC6 H2A clustered histone 6 -2.17728
SLC38A12 solute carrier family 38 member 12 -2.16345
UBTD1 ubiquitin domain containing 1 -2.16031
PPP6R2 protein phosphatase 6, regulatory subunit 2 -2.15376
CLASRP CLK4-associating serine/arginine rich protein -2.1512
ZNHIT2 zinc finger, HIT-type containing 2 -2.13221
REV1 REV1, polymerase (DNA directed) -2.126
CEP164 centrosomal protein 164kDa -2.11521
TM7SF3 transmembrane 7 superfamily member 3 -2.11242
NCLN nicalin -2.09511
PSD4 pleckstrin and Sec7 domain containing 4 -2.09153
ZFTRAF1 zinc finger TRAF-type containing 1 -2.08973
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.08867
SCAMP4 secretory carrier membrane protein 4 -2.08616
PEF1 penta-EF-hand domain containing 1 -2.0796
KLHDC2 kelch domain containing 2 -2.07608
QTRT1 queuine tRNA-ribosyltransferase 1 -2.06805
PIAS4 protein inhibitor of activated STAT, 4 -2.06644
THBS3 thrombospondin 3 -2.05775
L1CAM L1 cell adhesion molecule -2.05422
CD79B CD79b molecule, immunoglobulin-associated beta -2.03977
TMEM132A transmembrane protein 132A -2.0369
KRT14 keratin 14, type I -2.03117
PRCP prolylcarboxypeptidase (angiotensinase C) -2.0289
TUFT1 tuftelin 1 -2.02536
ATOX1 antioxidant 1 copper chaperone -2.00257
GZMM granzyme M (lymphocyte met-ase 1) -2.00149