CRCGN016_MCF10A.TP53.M_24H:L24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydroxyprogesterone caproate 11.09 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

164 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:L24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IL1B interleukin 1, beta 5.84282
FHL2 four and a half LIM domains 2 5.62563
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.65519
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.3181
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 4.29467
STX1A syntaxin 1A (brain) 4.21791
DUSP4 dual specificity phosphatase 4 3.9536
NUCB2 nucleobindin 2 3.79202
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.67143
BMP4 bone morphogenetic protein 4 3.56015
IER3 immediate early response 3 3.43466
AGR2 anterior gradient 2 3.36701
ALAS1 5'-aminolevulinate synthase 1 3.26581
NRIP1 nuclear receptor interacting protein 1 3.16839
IL1A interleukin 1, alpha 3.05317
MSRA methionine sulfoxide reductase A 3.00198
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.99681
EPN2 epsin 2 2.94929
METRN meteorin, glial cell differentiation regulator 2.93019
LRP10 low density lipoprotein receptor-related protein 10 2.91179
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.90907
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.81966
G0S2 G0/G1 switch 2 2.72196
PLEK2 pleckstrin 2 2.72014
CSF3 colony stimulating factor 3 (granulocyte) 2.70322
SYNGAP1 synaptic Ras GTPase activating protein 1 2.69769
LIF leukemia inhibitory factor 2.67872
FOSL1 FOS-like antigen 1 2.67062
EGR1 early growth response 1 2.60893
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.60332
DUSP6 dual specificity phosphatase 6 2.58459
VEGFC vascular endothelial growth factor C 2.52008
COPB1 coatomer protein complex, subunit beta 1 2.49515
IL4R interleukin 4 receptor 2.44431
HMGA2 high mobility group AT-hook 2 2.44133
ZMIZ1 zinc finger, MIZ-type containing 1 2.42737
SPRY4 sprouty homolog 4 (Drosophila) 2.40432
PYGL phosphorylase, glycogen, liver 2.40334
HBEGF heparin-binding EGF-like growth factor 2.36154
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.34987
PRSS3 protease, serine, 3 2.3489
RAB31 RAB31, member RAS oncogene family 2.30996
FAM114A1 family with sequence similarity 114, member A1 2.29124
CDPF1 cysteine-rich, DPF motif domain containing 1 2.25743
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.24995
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 2.18523
PADI3 peptidyl arginine deiminase, type III 2.17825
CDCP1 CUB domain containing protein 1 2.1773
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.17545
CCNA1 cyclin A1 2.17091
EREG epiregulin 2.15694
CALU calumenin 2.1436
NT5E 5'-nucleotidase, ecto (CD73) 2.13154
DCBLD2 discoidin, CUB and LCCL domain containing 2 2.12032
ACBD3 acyl-CoA binding domain containing 3 2.11672
PLAT plasminogen activator, tissue 2.11105
CD70 CD70 molecule 2.08761
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.08642
SLC67A1 solute carrier family 67 member 1 2.07387
MMP14 matrix metallopeptidase 14 (membrane-inserted) 2.0639
CUL7 cullin 7 2.06087
EPHB2 EPH receptor B2 2.04571
COL9A3 collagen, type IX, alpha 3 2.04246
LTN1 listerin E3 ubiquitin protein ligase 1 2.03225
PAQR4 progestin and adipoQ receptor family member IV 2.01495
IL24 interleukin 24 2.00932
GLRX glutaredoxin (thioltransferase) 2.0052
GOLGA3 golgin A3 2.00474

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -6.01659
TSC22D3 TSC22 domain family, member 3 -5.4899
ADRB2 adrenoceptor beta 2, surface -4.91762
GRWD1 glutamate-rich WD repeat containing 1 -4.61948
CIAPIN1 cytokine induced apoptosis inhibitor 1 -4.35857
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.1366
CD320 CD320 molecule -3.90094
PRR15L proline rich 15-like -3.86355
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -3.84402
MSMO1 methylsterol monooxygenase 1 -3.7177
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.5171
HEATR1 HEAT repeat containing 1 -3.51641
HMG20B high mobility group 20B -3.50005
TM9SF3 transmembrane 9 superfamily member 3 -3.21578
RGS2 regulator of G-protein signaling 2 -3.15546
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -3.05216
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.04066
RPUSD2 RNA pseudouridylate synthase domain containing 2 -2.93355
HSPA1A heat shock 70kDa protein 1A -2.82578
CDK4 cyclin-dependent kinase 4 -2.78138
NFIL3 nuclear factor, interleukin 3 regulated -2.67205
MRPL11 mitochondrial ribosomal protein L11 -2.64711
RPP40 ribonuclease P/MRP 40kDa subunit -2.64245
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -2.59015
COPS6 COP9 signalosome subunit 6 -2.56209
TWNK twinkle mtDNA helicase -2.55221
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.53257
RBM48 RNA binding motif protein 48 -2.51753
UROS uroporphyrinogen III synthase -2.51071
PALS2 protein associated with LIN7 2, MAGUK p55 family member -2.50015
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -2.49722
GADD45B growth arrest and DNA-damage-inducible, beta -2.4906
MYNN myoneurin -2.4901
BAG1 BCL2-associated athanogene -2.48991
INSIG1 insulin induced gene 1 -2.47556
COMMD9 COMM domain containing 9 -2.44754
ADI1 acireductone dioxygenase 1 -2.40432
BET1 Bet1 golgi vesicular membrane trafficking protein -2.4026
ZNF322 zinc finger protein 322 -2.39408
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -2.37566
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.37318
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa -2.35674
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.35537
ZNF35 zinc finger protein 35 -2.35235
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.34652
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.30839
GCDH glutaryl-CoA dehydrogenase -2.30699
WDCP WD repeat and coiled coil containing -2.30417
CGRRF1 cell growth regulator with ring finger domain 1 -2.30045
HSPA1B heat shock 70kDa protein 1B -2.28842
EDN1 endothelin 1 -2.2843
SV2C synaptic vesicle glycoprotein 2C -2.27301
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -2.26845
NAT10 N-acetyltransferase 10 (GCN5-related) -2.26184
DCAF17 DDB1 and CUL4 associated factor 17 -2.25361
C2CD5 C2 calcium-dependent domain containing 5 -2.25036
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.22355
TRAPPC2L trafficking protein particle complex 2-like -2.18326
ESRP2 epithelial splicing regulatory protein 2 -2.15673
CDC37L1 cell division cycle 37-like 1 -2.15656
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.15497
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.14218
ABHD4 abhydrolase domain containing 4 -2.13106
CDC45 cell division cycle 45 -2.12913
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.12621
SCGB1D1 secretoglobin, family 1D, member 1 -2.12328
LIFR leukemia inhibitory factor receptor alpha -2.10512
CRIPT cysteine-rich PDZ-binding protein -2.10264
MRPS18A mitochondrial ribosomal protein S18A -2.10006
CPEB3 cytoplasmic polyadenylation element binding protein 3 -2.09955
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.09771
SMNDC1 survival motor neuron domain containing 1 -2.09446
BIRC5 baculoviral IAP repeat containing 5 -2.09356
INTS5 integrator complex subunit 5 -2.0814
MCM3 minichromosome maintenance complex component 3 -2.07853
CINP cyclin-dependent kinase 2 interacting protein -2.07693
PRODH proline dehydrogenase (oxidase) 1 -2.07616
PARPBP PARP1 binding protein -2.07362
BABAM1 BRISC and BRCA1 A complex member 1 -2.06253
MEPCE methylphosphate capping enzyme -2.06226
NR1H3 nuclear receptor subfamily 1, group H, member 3 -2.05828
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.05465
ASTN2 astrotactin 2 -2.05419
RBM34 RNA binding motif protein 34 -2.04358
METTL18 methyltransferase like 18 -2.03844
CLN3 ceroid-lipofuscinosis, neuronal 3 -2.03149
ATXN7L1 ataxin 7-like 1 -2.02806
CLCN5 chloride channel, voltage-sensitive 5 -2.02216
SH3D19 SH3 domain containing 19 -2.01974
TMEM100 transmembrane protein 100 -2.01706
WDR3 WD repeat domain 3 -2.01488
ZNHIT1 zinc finger, HIT-type containing 1 -2.01128
TMEM126B transmembrane protein 126B -2.00826
MRPL46 mitochondrial ribosomal protein L46 -2.00738
MRPL34 mitochondrial ribosomal protein L34 -2.00439
TXNL4B thioredoxin-like 4B -2.00315