CRCGN016_MCF10A.TP53.M_24H:M07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description beta testosterone 99.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

88 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:M07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HBA1 hemoglobin, alpha 1 3.88457
HMGA2 high mobility group AT-hook 2 3.867
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.79529
FHL2 four and a half LIM domains 2 3.3716
IL1B interleukin 1, beta 3.29072
DUSP4 dual specificity phosphatase 4 2.89111
EGR1 early growth response 1 2.79493
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.72548
FBXO11 F-box protein 11 2.69654
PLS1 plastin 1 2.69361
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.65014
KDM5D lysine (K)-specific demethylase 5D 2.59053
MAMLD1 mastermind-like domain containing 1 2.56028
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.5196
NRBF2 nuclear receptor binding factor 2 2.28302
IL1A interleukin 1, alpha 2.27997
LMO2 LIM domain only 2 (rhombotin-like 1) 2.27904
DUSP6 dual specificity phosphatase 6 2.27171
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.26096
IL24 interleukin 24 2.23205
PUM3 pumilio RNA binding family member 3 2.20126
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.19105
GOLGA6L9 golgin A6 family-like 9 2.17678
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.16838
NRIP1 nuclear receptor interacting protein 1 2.13687
MORC3 MORC family CW-type zinc finger 3 2.13178
AHCTF1 AT hook containing transcription factor 1 2.12551
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.08698
WAPL WAPL cohesin release factor 2.08209
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa 2.05941
ZNF267 zinc finger protein 267 2.0412
TRIB1 tribbles pseudokinase 1 2.03394
LOC102724023 ES1 protein homolog, mitochondrial 2.02775
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.01976
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.01209

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.30009
PUF60 poly-U binding splicing factor 60KDa -4.08601
THAP11 THAP domain containing 11 -3.62464
CCNB1 cyclin B1 -3.4513
TSC22D3 TSC22 domain family, member 3 -3.42037
NUP85 nucleoporin 85kDa -3.29243
CDC45 cell division cycle 45 -3.19412
DDIT4 DNA-damage-inducible transcript 4 -2.92201
NLRP4 NLR family, pyrin domain containing 4 -2.82088
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.74423
TCN2 transcobalamin II -2.71557
TUBA4A tubulin, alpha 4a -2.69928
VDAC1 voltage-dependent anion channel 1 -2.69619
NOSIP nitric oxide synthase interacting protein -2.67158
ADRB2 adrenoceptor beta 2, surface -2.60255
MRPS7 mitochondrial ribosomal protein S7 -2.59255
STXBP2 syntaxin binding protein 2 -2.57025
CABIN1 calcineurin binding protein 1 -2.54005
C1QBP complement component 1, q subcomponent binding protein -2.51508
GGT5 gamma-glutamyltransferase 5 -2.49563
MRPL58 mitochondrial ribosomal protein L58 -2.46997
GADD45B growth arrest and DNA-damage-inducible, beta -2.46271
ARMC7 armadillo repeat containing 7 -2.43483
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like -2.43273
CASKIN2 CASK interacting protein 2 -2.399
SMC1A structural maintenance of chromosomes 1A -2.36137
ZNF16 zinc finger protein 16 -2.34057
ZMAT5 zinc finger, matrin-type 5 -2.33991
FKBP5 FK506 binding protein 5 -2.30131
ALG12 ALG12, alpha-1,6-mannosyltransferase -2.28265
GSR glutathione reductase -2.24962
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.24239
GSDMD gasdermin D -2.22668
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) -2.21954
CAPN1 calpain 1, (mu/I) large subunit -2.16554
TKT transketolase -2.1616
MVD mevalonate (diphospho) decarboxylase -2.16021
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.15482
CDR2L cerebellar degeneration-related protein 2-like -2.1444
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.12866
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.11585
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.10895
C1QA complement component 1, q subcomponent, A chain -2.10579
ATP5PD ATP synthase peripheral stalk subunit d -2.09147
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.09053
A4GALT alpha 1,4-galactosyltransferase -2.08724
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 -2.0806
KAT5 K(lysine) acetyltransferase 5 -2.06713
C1QB complement component 1, q subcomponent, B chain -2.06634
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.05162
LIME1 Lck interacting transmembrane adaptor 1 -2.03859
KPTN kaptin (actin binding protein) -2.02418
GALK1 galactokinase 1 -2.02207