CRCGN016_MCF10A.TP53.M_24H:M09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description beta testosterone 11.03 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

260 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:M09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MEF2C myocyte enhancer factor 2C 5.77863
MYLK myosin light chain kinase 5.31791
PPARG peroxisome proliferator-activated receptor gamma 5.28681
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.05304
WIF1 WNT inhibitory factor 1 4.55066
ACTG2 actin, gamma 2, smooth muscle, enteric 3.80253
KDM5D lysine (K)-specific demethylase 5D 3.59285
IGHMBP2 immunoglobulin mu binding protein 2 3.56609
COMP cartilage oligomeric matrix protein 3.5557
BACE2 beta-site APP-cleaving enzyme 2 3.52433
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.47143
SQOR sulfide quinone oxidoreductase 3.42046
OGN osteoglycin 3.41577
MMP1 matrix metallopeptidase 1 3.36675
PEX11A peroxisomal biogenesis factor 11 alpha 3.29112
SYNPO2L synaptopodin 2-like 3.18876
MAST2 microtubule associated serine/threonine kinase 2 3.16391
FSCN3 fascin actin-bundling protein 3, testicular 3.14119
MYL1 myosin, light chain 1, alkali; skeletal, fast 3.12574
USP9Y ubiquitin specific peptidase 9, Y-linked 3.09877
IL17B interleukin 17B 3.09065
TNNI1 troponin I type 1 (skeletal, slow) 3.04853
MYF6 myogenic factor 6 (herculin) 2.95776
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.8808
ACTN2 actinin, alpha 2 2.87193
SMPX small muscle protein, X-linked 2.84334
SPARCL1 SPARC-like 1 (hevin) 2.82764
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 2.81765
ADAM30 ADAM metallopeptidase domain 30 2.81556
ZFPM2 zinc finger protein, FOG family member 2 2.7785
TNNC2 troponin C type 2 (fast) 2.75066
TPM3 tropomyosin 3 2.72662
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide 2.72476
KRT76 keratin 76, type II 2.71726
MYBPC1 myosin binding protein C, slow type 2.68465
BNC2 basonuclin 2 2.65255
MYL11 myosin light chain 11 2.65245
MYOZ2 myozenin 2 2.58405
BICRAL BICRA like chromatin remodeling complex associated protein 2.5549
TDRD1 tudor domain containing 1 2.55321
RFPL2 ret finger protein-like 2 2.54778
SOX5 SRY (sex determining region Y)-box 5 2.51072
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.51068
CASQ2 calsequestrin 2 (cardiac muscle) 2.50416
DLK1 delta-like 1 homolog (Drosophila) 2.49202
CATSPERG catsper channel auxiliary subunit gamma 2.49076
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.48837
ZNF135 zinc finger protein 135 2.48147
TNNT3 troponin T type 3 (skeletal, fast) 2.47316
AKAP4 A kinase (PRKA) anchor protein 4 2.46606
SLN sarcolipin 2.45902
FGFR4 fibroblast growth factor receptor 4 2.42463
HRC histidine rich calcium binding protein 2.42441
RFPL3 ret finger protein-like 3 2.4239
DUSP13A dual specificity phosphatase 13A 2.4226
ODF1 outer dense fiber of sperm tails 1 2.42222
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.4192
NCALD neurocalcin delta 2.41691
RBMY1J RNA binding motif protein, Y-linked, family 1, member J 2.41483
ZNF532 zinc finger protein 532 2.41335
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.41185
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.40442
MROH7 maestro heat-like repeat family member 7 2.37747
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.37376
OR5I1 olfactory receptor, family 5, subfamily I, member 1 2.37263
ZFY zinc finger protein, Y-linked 2.37017
A2M alpha-2-macroglobulin 2.36512
CLDND1 claudin domain containing 1 2.36076
SUMF2 sulfatase modifying factor 2 2.35152
NOVA1 neuro-oncological ventral antigen 1 2.34862
CAV3 caveolin 3 2.34467
KLHL41 kelch-like family member 41 2.34439
FMO1 flavin containing monooxygenase 1 2.34342
KERA keratocan 2.33857
CKM creatine kinase, muscle 2.33785
DDR2 discoidin domain receptor tyrosine kinase 2 2.33765
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.33706
COL14A1 collagen, type XIV, alpha 1 2.33668
EGFL6 EGF-like-domain, multiple 6 2.32914
SPATA31A3 SPATA31 subfamily A, member 3 2.32362
DPY19L1 dpy-19-like 1 (C. elegans) 2.32263
BRDT bromodomain, testis-specific 2.32043
TNMD tenomodulin 2.31971
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.31799
COL5A2 collagen, type V, alpha 2 2.30962
TRDN triadin 2.30559
SHCBP1L SHC SH2-domain binding protein 1-like 2.28726
ACTA1 actin, alpha 1, skeletal muscle 2.28246
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 2.27933
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.2759
ELF5 E74-like factor 5 (ets domain transcription factor) 2.26794
TNNI2 troponin I type 2 (skeletal, fast) 2.26458
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 2.26272
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 2.26071
ZPBP zona pellucida binding protein 2.26041
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.25678
GJA1 gap junction protein, alpha 1, 43kDa 2.25202
PCDH17 protocadherin 17 2.25185
LDHAL6B lactate dehydrogenase A-like 6B 2.24576
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.24472
GK2 glycerol kinase 2 2.2337
ZNF267 zinc finger protein 267 2.23214
PYGM phosphorylase, glycogen, muscle 2.22934
PLSCR2 phospholipid scramblase 2 2.22858
MYBPH myosin binding protein H 2.22213
SYNM synemin, intermediate filament protein 2.21737
TBK1 TANK-binding kinase 1 2.21534
TULP2 tubby like protein 2 2.20778
PRRX1 paired related homeobox 1 2.20328
MFF mitochondrial fission factor 2.2031
TAS2R8 taste receptor, type 2, member 8 2.19532
PARM1 prostate androgen-regulated mucin-like protein 1 2.18971
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 2.18964
NID2 nidogen 2 (osteonidogen) 2.18898
DOCK3 dedicator of cytokinesis 3 2.18738
DAZ2 deleted in azoospermia 2 2.18407
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 2.18386
KRT36 keratin 36, type I 2.18356
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.18334
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 2.17777
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 2.17157
DNASE2B deoxyribonuclease II beta 2.171
CCL11 chemokine (C-C motif) ligand 11 2.16533
EIF3J eukaryotic translation initiation factor 3, subunit J 2.16048
ANKRD7 ankyrin repeat domain 7 2.15914
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 2.15796
ZNF280B zinc finger protein 280B 2.15291
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.14845
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.14376
GPR22 G protein-coupled receptor 22 2.14296
PDLIM3 PDZ and LIM domain 3 2.13209
NMBR neuromedin B receptor 2.13024
UBXN8 UBX domain protein 8 2.1258
SMAD3 SMAD family member 3 2.12216
CADM1 cell adhesion molecule 1 2.11381
SPIN2B spindlin family, member 2B 2.11303
EFHD1 EF-hand domain family, member D1 2.10679
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.10283
AOC2 amine oxidase, copper containing 2 (retina-specific) 2.10103
COL15A1 collagen, type XV, alpha 1 2.09958
MB myoglobin 2.09549
ANK2 ankyrin 2, neuronal 2.09364
ASIC2 acid sensing (proton gated) ion channel 2 2.08411
COL11A1 collagen, type XI, alpha 1 2.08005
NEB nebulin 2.07874
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 2.07805
ACRV1 acrosomal vesicle protein 1 2.07781
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.07645
CNKSR2 connector enhancer of kinase suppressor of Ras 2 2.07615
ROPN1B rhophilin associated tail protein 1B 2.07299
TFDP3 transcription factor Dp family, member 3 2.06626
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 2.06543
LDHC lactate dehydrogenase C 2.06372
PDGFC platelet derived growth factor C 2.06211
MYH2 myosin, heavy chain 2, skeletal muscle, adult 2.06004
IGFBP5 insulin-like growth factor binding protein 5 2.05865
CSRNP3 cysteine-serine-rich nuclear protein 3 2.05801
ACKR2 atypical chemokine receptor 2 2.05746
ZFR2 zinc finger RNA binding protein 2 2.05452
MAPK10 mitogen-activated protein kinase 10 2.05258
GSG1 germ cell associated 1 2.04707
TRAPPC11 trafficking protein particle complex 11 2.04192
NOL10 nucleolar protein 10 2.04146
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 2.04116
IL36A interleukin 36, alpha 2.03907
IL3 interleukin 3 2.03788
PCDHB3 protocadherin beta 3 2.03565
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.03439
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.03257
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.03196
TTLL7 tubulin tyrosine ligase-like family member 7 2.03088
H2BC14 H2B clustered histone 14 2.0257
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.02463
TCP11 t-complex 11, testis-specific 2.02422
ZNF804A zinc finger protein 804A 2.02326
EEF1AKMT3 EEF1A lysine methyltransferase 3 2.02325
PLAC1 placenta-specific 1 2.02288
PRDM11 PR domain containing 11 2.02278
SSPN sarcospan 2.02054
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.01922
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 2.01914
ARHGAP6 Rho GTPase activating protein 6 2.01861
HSFX2 heat shock transcription factor family, X linked 2 2.01738
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 2.01333
SRPK3 SRSF protein kinase 3 2.01315
WDR7 WD repeat domain 7 2.01218
DCSTAMP dendrocyte expressed seven transmembrane protein 2.009
SCRG1 stimulator of chondrogenesis 1 2.00877
BET1 Bet1 golgi vesicular membrane trafficking protein 2.00742
MYOZ1 myozenin 1 2.00536
ARHGAP29 Rho GTPase activating protein 29 2.00288
KIF17 kinesin family member 17 2.0026
NPY5R neuropeptide Y receptor Y5 2.00098

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -6.48076
OXA1L oxidase (cytochrome c) assembly 1-like -6.29843
CCNB1 cyclin B1 -4.68253
CLTB clathrin, light chain B -4.66035
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.43446
TNIP1 TNFAIP3 interacting protein 1 -4.42346
RPIA ribose 5-phosphate isomerase A -4.4222
PFN1 profilin 1 -4.20897
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.953
HMG20B high mobility group 20B -3.31077
GRWD1 glutamate-rich WD repeat containing 1 -3.2715
TUBA4A tubulin, alpha 4a -3.16121
SMC1A structural maintenance of chromosomes 1A -2.93423
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.88576
FZD2 frizzled class receptor 2 -2.77595
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.72255
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 -2.68929
DYNLT3 dynein, light chain, Tctex-type 3 -2.67061
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.58707
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.54847
UBA1 ubiquitin-like modifier activating enzyme 1 -2.53666
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -2.51489
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -2.48153
NUAK2 NUAK family, SNF1-like kinase, 2 -2.47855
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.47308
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.44262
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.44236
CHMP7 charged multivesicular body protein 7 -2.44209
GPS1 G protein pathway suppressor 1 -2.44157
ETFB electron-transfer-flavoprotein, beta polypeptide -2.43232
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) -2.43141
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -2.37574
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 -2.33943
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.31745
TKT transketolase -2.31157
SEPTIN6 septin 6 -2.28733
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -2.28433
GFUS GDP-L-fucose synthase -2.27366
GRN granulin -2.26929
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -2.24377
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -2.23898
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.23736
MRPL12 mitochondrial ribosomal protein L12 -2.21401
RAB3A RAB3A, member RAS oncogene family -2.21396
NHP2 NHP2 ribonucleoprotein -2.20668
TWF2 twinfilin actin binding protein 2 -2.20222
PNKP polynucleotide kinase 3'-phosphatase -2.191
HSPB1 heat shock 27kDa protein 1 -2.17368
TMEM115 transmembrane protein 115 -2.17283
TTC31 tetratricopeptide repeat domain 31 -2.16523
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -2.12316
DDIT4 DNA-damage-inducible transcript 4 -2.10932
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.10144
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.09293
ADIPOR1 adiponectin receptor 1 -2.08869
MPST mercaptopyruvate sulfurtransferase -2.08867
DOLK dolichol kinase -2.08373
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.07549
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.06706
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.06638
FOXD1 forkhead box D1 -2.06386
ZNF219 zinc finger protein 219 -2.05969
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -2.05722
PGAP6 post-GPI attachment to proteins 6 -2.05484
BLCAP bladder cancer associated protein -2.04801
ADGRE5 adhesion G protein-coupled receptor E5 -2.03312
ESRRA estrogen-related receptor alpha -2.00892