CRCGN016_MCF10A.TP53.M_24H:M18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorphenamine 11.09 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

19 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:M18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.2946
TBX2 T-box 2 2.99346
NUCB2 nucleobindin 2 2.68044
CNRIP1 cannabinoid receptor interacting protein 1 2.50836
MMP1 matrix metallopeptidase 1 2.47241
ANGPT1 angiopoietin 1 2.44036
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.17542

decreased expression

Symbol Name Standardized Value
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.59201
VDAC1 voltage-dependent anion channel 1 -4.07573
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.67637
PIH1D1 PIH1 domain containing 1 -3.64414
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -3.25106
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.118
GDF15 growth differentiation factor 15 -2.78667
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.5886
NGRN neugrin, neurite outgrowth associated -2.54829
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.27979
WDR73 WD repeat domain 73 -2.07948
RRAGD Ras-related GTP binding D -2.00425