CRCGN016_MCF10A.TP53.M_24H:M19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ITE 102.69 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

120 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:M19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KLHL21 kelch-like family member 21 6.23472
SSBP2 single-stranded DNA binding protein 2 6.00357
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.6881
RPL39L ribosomal protein L39-like 5.51549
PEX11A peroxisomal biogenesis factor 11 alpha 5.04394
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.44385
TOMM34 translocase of outer mitochondrial membrane 34 4.43876
SQOR sulfide quinone oxidoreductase 4.26352
AGR2 anterior gradient 2 3.95156
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 3.93766
KIF5C kinesin family member 5C 3.83225
EPN2 epsin 2 3.69825
METRN meteorin, glial cell differentiation regulator 3.52438
STAP2 signal transducing adaptor family member 2 3.2455
ZBTB6 zinc finger and BTB domain containing 6 3.09503
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.91606
BLTP2 bridge-like lipid transfer protein family member 2 2.68903
IL1B interleukin 1, beta 2.63016
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.54939
PELI2 pellino E3 ubiquitin protein ligase family member 2 2.51745
SIPA1L1 signal-induced proliferation-associated 1 like 1 2.49283
OCRL oculocerebrorenal syndrome of Lowe 2.48427
ZNF510 zinc finger protein 510 2.48254
NAP1L2 nucleosome assembly protein 1-like 2 2.47543
OSGIN2 oxidative stress induced growth inhibitor family member 2 2.4663
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.46498
SDF2 stromal cell-derived factor 2 2.46451
ZBTB35 zinc finger and BTB domain containing 35 2.4583
ACLY ATP citrate lyase 2.4305
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.41777
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.40135
CNRIP1 cannabinoid receptor interacting protein 1 2.38063
TRPS1 trichorhinophalangeal syndrome I 2.36275
TRAF4 TNF receptor-associated factor 4 2.31879
PTHLH parathyroid hormone-like hormone 2.31875
GLIPR1 GLI pathogenesis-related 1 2.31667
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 2.31359
TUBGCP5 tubulin, gamma complex associated protein 5 2.30724
DHRS11 dehydrogenase/reductase (SDR family) member 11 2.30397
PEX12 peroxisomal biogenesis factor 12 2.29519
TLR4 toll-like receptor 4 2.2916
AZIN2 antizyme inhibitor 2 2.28462
STARD13 StAR-related lipid transfer (START) domain containing 13 2.28418
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 2.28345
KCTD5 potassium channel tetramerization domain containing 5 2.26255
SUSD6 sushi domain containing 6 2.26237
SDHAF3 succinate dehydrogenase complex assembly factor 3 2.25964
FRK fyn-related Src family tyrosine kinase 2.23151
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.19252
RAB4B RAB4B, member RAS oncogene family 2.19039
FAM168A family with sequence similarity 168, member A 2.18518
FAM222B family with sequence similarity 222, member B 2.17281
ADPRH ADP-ribosylarginine hydrolase 2.1649
DIXDC1 DIX domain containing 1 2.16269
ZNF227 zinc finger protein 227 2.15626
NLGN1 neuroligin 1 2.15594
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 2.15376
SAP30 Sin3A-associated protein, 30kDa 2.15086
KDM5D lysine (K)-specific demethylase 5D 2.14864
ATG13 autophagy related 13 2.14743
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.13994
CLMN calmin (calponin-like, transmembrane) 2.13877
SLC38A6 solute carrier family 38, member 6 2.12739
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.10944
SCGN secretagogin, EF-hand calcium binding protein 2.09766
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 2.09354
LIN7A lin-7 homolog A (C. elegans) 2.09222
SPATA7 spermatogenesis associated 7 2.0906
DZIP1 DAZ interacting zinc finger protein 1 2.0869
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 2.07941
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 2.07568
GSTT1 glutathione S-transferase theta 1 2.07219
PCDHGA3 protocadherin gamma subfamily A, 3 2.06142
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 2.05924
DENND4A DENN/MADD domain containing 4A 2.05109
RNF14 ring finger protein 14 2.04985
MBNL3 muscleblind-like splicing regulator 3 2.04648
HAS2 hyaluronan synthase 2 2.0376
TBXT T-box transcription factor T 2.03523
RIOK2 RIO kinase 2 2.03121
CER1 cerberus 1, DAN family BMP antagonist 2.02826
TMEM267 transmembrane protein 267 2.02712
SRR serine racemase 2.0271
ZBTB20 zinc finger and BTB domain containing 20 2.02422
RAB28 RAB28, member RAS oncogene family 2.01179
URI1 URI1, prefoldin-like chaperone 2.00165

decreased expression

Symbol Name Standardized Value
ACOT9 acyl-CoA thioesterase 9 -6.08843
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.81918
ATF5 activating transcription factor 5 -3.97798
DIPK1A divergent protein kinase domain 1A -3.95899
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.89989
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.59959
CDK4 cyclin-dependent kinase 4 -3.48905
PRDX4 peroxiredoxin 4 -3.30466
ATOX1 antioxidant 1 copper chaperone -2.97552
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.80533
METTL17 methyltransferase like 17 -2.71917
RNF187 ring finger protein 187 -2.6832
BCKDK branched chain ketoacid dehydrogenase kinase -2.54364
TM9SF3 transmembrane 9 superfamily member 3 -2.53308
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.52694
HLA-F major histocompatibility complex, class I, F -2.45279
PTMS parathymosin -2.3671
CCNB2 cyclin B2 -2.35659
CTSH cathepsin H -2.35405
SMC1A structural maintenance of chromosomes 1A -2.25793
DERA deoxyribose-phosphate aldolase (putative) -2.21215
RCE1 Ras converting CAAX endopeptidase 1 -2.19421
MLF2 myeloid leukemia factor 2 -2.17817
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.17071
GRWD1 glutamate-rich WD repeat containing 1 -2.15859
HOXB3 homeobox B3 -2.14705
SIPA1L3 signal-induced proliferation-associated 1 like 3 -2.13742
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 -2.13319
COQ9 coenzyme Q9 -2.10258
GOLT1A golgi transport 1A -2.07333
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.06257
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 -2.05959
GNPAT glyceronephosphate O-acyltransferase -2.04661
ARHGAP4 Rho GTPase activating protein 4 -2.03629