CRCGN016_MCF10A.TP53.M_24H:M21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ITE 11.41 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

93 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:M21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 4.51295
MAP7 microtubule-associated protein 7 4.31436
DHRS2 dehydrogenase/reductase (SDR family) member 2 4.18746
CNRIP1 cannabinoid receptor interacting protein 1 4.18045
AGR2 anterior gradient 2 4.1389
PLS1 plastin 1 3.37361
TOMM34 translocase of outer mitochondrial membrane 34 3.35757
MAST2 microtubule associated serine/threonine kinase 2 2.74916
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.63153
SYNGAP1 synaptic Ras GTPase activating protein 1 2.55077
ZNF451 zinc finger protein 451 2.42178
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.40186
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.37734
RAB31 RAB31, member RAS oncogene family 2.34726
TM2D3 TM2 domain containing 3 2.20544
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 2.19473
BAMBI BMP and activin membrane-bound inhibitor 2.17069
MMP3 matrix metallopeptidase 3 2.14045
ZNF761 zinc finger protein 761 2.13953
SNRPG small nuclear ribonucleoprotein polypeptide G 2.13571
CRLF3 cytokine receptor-like factor 3 2.08355
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.08149
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.0598
EMC6 ER membrane protein complex subunit 6 2.03425
MPHOSPH6 M-phase phosphoprotein 6 2.0232
TEFM transcription elongation factor, mitochondrial 2.01362
H2BC12 H2B clustered histone 12 2.0076

decreased expression

Symbol Name Standardized Value
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.85575
PUF60 poly-U binding splicing factor 60KDa -4.66192
MRPS2 mitochondrial ribosomal protein S2 -4.43919
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.33585
CCNB1 cyclin B1 -4.21771
VDAC1 voltage-dependent anion channel 1 -4.07521
PAEP progestagen-associated endometrial protein -3.84483
BASP1 brain abundant, membrane attached signal protein 1 -3.83854
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.76036
CANT1 calcium activated nucleotidase 1 -3.71326
NLRP4 NLR family, pyrin domain containing 4 -3.66377
MSMO1 methylsterol monooxygenase 1 -3.39967
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.86901
SCRIB scribbled planar cell polarity protein -2.81405
BPHL biphenyl hydrolase-like (serine hydrolase) -2.80386
FAM50B family with sequence similarity 50, member B -2.69423
PTGDS prostaglandin D2 synthase 21kDa (brain) -2.66191
ZMYM2 zinc finger, MYM-type 2 -2.64665
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 -2.50967
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.48068
TMEM53 transmembrane protein 53 -2.47111
SEC16A SEC16 homolog A (S. cerevisiae) -2.44273
SOAT2 sterol O-acyltransferase 2 -2.3866
HAAO 3-hydroxyanthranilate 3,4-dioxygenase -2.36756
THEM6 thioesterase superfamily member 6 -2.3452
RNF208 ring finger protein 208 -2.31212
CHRM3 cholinergic receptor, muscarinic 3 -2.29207
RALYL RALY RNA binding protein-like -2.29144
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -2.28116
DOLPP1 dolichyldiphosphatase 1 -2.27402
CLDN16 claudin 16 -2.26801
MYG1 MYG1 exonuclease -2.26656
CCN6 cellular communication network factor 6 -2.25629
MPST mercaptopyruvate sulfurtransferase -2.25592
ZNHIT1 zinc finger, HIT-type containing 1 -2.25469
CAPN2 calpain 2, (m/II) large subunit -2.25381
NME3 NME/NM23 nucleoside diphosphate kinase 3 -2.21337
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.20663
NEO1 neogenin 1 -2.20587
MRPS27 mitochondrial ribosomal protein S27 -2.18427
ZNF506 zinc finger protein 506 -2.17996
OBP2B odorant binding protein 2B -2.17112
NR1I3 nuclear receptor subfamily 1, group I, member 3 -2.17061
WDR6 WD repeat domain 6 -2.16436
SHARPIN SHANK-associated RH domain interactor -2.14989
NHERF4 NHERF family PDZ scaffold protein 4 -2.13675
PMPCA peptidase (mitochondrial processing) alpha -2.13609
NXF2B nuclear RNA export factor 2B -2.13003
JRK Jrk homolog (mouse) -2.11208
MAPK10 mitogen-activated protein kinase 10 -2.11177
OBP2A odorant binding protein 2A -2.11122
BARX1 BARX homeobox 1 -2.09331
PYCR3 pyrroline-5-carboxylate reductase 3 -2.09276
TMEM255A transmembrane protein 255A -2.08464
AMPD2 adenosine monophosphate deaminase 2 -2.07629
CEND1 cell cycle exit and neuronal differentiation 1 -2.06476
MOSPD3 motile sperm domain containing 3 -2.05792
RFPL3 ret finger protein-like 3 -2.05046
PRODH2 proline dehydrogenase (oxidase) 2 -2.04472
CXXC4 CXXC finger protein 4 -2.03808
TRIM66 tripartite motif containing 66 -2.03097
ETV7 ets variant 7 -2.03028
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 -2.02434
THRB thyroid hormone receptor, beta -2.02368
NRSN2 neurensin 2 -2.01763
SKIC3 SKI3 subunit of superkiller complex -2.00839