CRCGN016_MCF10A.TP53.M_24H:M22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimetridazole 98.38 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

190 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:M22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 8.51451
MYLK myosin light chain kinase 4.9995
ADGRE5 adhesion G protein-coupled receptor E5 4.89748
CNRIP1 cannabinoid receptor interacting protein 1 4.35236
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 4.21711
CADM1 cell adhesion molecule 1 3.71026
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 3.26658
C5 complement component 5 3.24875
BSPRY B-box and SPRY domain containing 3.21847
HBA1 hemoglobin, alpha 1 3.12138
BMP4 bone morphogenetic protein 4 3.09972
ATL2 atlastin GTPase 2 3.06862
GPATCH8 G patch domain containing 8 3.01095
IGHMBP2 immunoglobulin mu binding protein 2 2.87542
KDM5D lysine (K)-specific demethylase 5D 2.84794
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.81169
USP9Y ubiquitin specific peptidase 9, Y-linked 2.7594
ESRP1 epithelial splicing regulatory protein 1 2.71587
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 2.69133
CETN3 centrin, EF-hand protein, 3 2.66555
RIMS1 regulating synaptic membrane exocytosis 1 2.65479
PAIP2B poly(A) binding protein interacting protein 2B 2.6516
WFDC1 WAP four-disulfide core domain 1 2.62691
CIDEB cell death-inducing DFFA-like effector b 2.5967
PI15 peptidase inhibitor 15 2.59645
SNX7 sorting nexin 7 2.58162
FAM184A family with sequence similarity 184, member A 2.52425
ZNF528 zinc finger protein 528 2.505
CAMKMT calmodulin-lysine N-methyltransferase 2.47802
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 2.46326
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 2.44525
SSBP3 single stranded DNA binding protein 3 2.44052
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.43963
TOPBP1 topoisomerase (DNA) II binding protein 1 2.43807
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.41962
PREB prolactin regulatory element binding 2.41008
FOXA2 forkhead box A2 2.39792
TMEM242 transmembrane protein 242 2.39704
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 2.39536
ASGR2 asialoglycoprotein receptor 2 2.38889
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.38823
LGMN legumain 2.38682
CASD1 CAS1 domain containing 1 2.38435
MYH11 myosin, heavy chain 11, smooth muscle 2.37419
POPDC2 popeye domain containing 2 2.35959
ZNF816 zinc finger protein 816 2.35347
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.34982
ZNF835 zinc finger protein 835 2.34651
PROX1 prospero homeobox 1 2.34304
TNK1 tyrosine kinase, non-receptor, 1 2.34278
CA8 carbonic anhydrase VIII 2.34163
FBXO41 F-box protein 41 2.33345
ZNF747 zinc finger protein 747 2.33005
SIDT1 SID1 transmembrane family, member 1 2.31494
SOD3 superoxide dismutase 3, extracellular 2.31115
PCYOX1 prenylcysteine oxidase 1 2.30965
LYZ lysozyme 2.30571
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.30242
FGF7 fibroblast growth factor 7 2.2977
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.29397
ISL1 ISL LIM homeobox 1 2.28096
GZMM granzyme M (lymphocyte met-ase 1) 2.27784
CCKBR cholecystokinin B receptor 2.27565
ANGPT1 angiopoietin 1 2.26477
CNN1 calponin 1, basic, smooth muscle 2.25937
SPDEF SAM pointed domain containing ETS transcription factor 2.25055
PRSS23 protease, serine, 23 2.23951
TCTN2 tectonic family member 2 2.23595
TENT5C terminal nucleotidyltransferase 5C 2.22882
RHOB ras homolog family member B 2.2176
SV2A synaptic vesicle glycoprotein 2A 2.2163
AMT aminomethyltransferase 2.21411
SYK spleen tyrosine kinase 2.20873
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.20233
MEFV Mediterranean fever 2.19355
FMO5 flavin containing monooxygenase 5 2.1782
YIPF1 Yip1 domain family, member 1 2.17783
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 2.17555
LRRC61 leucine rich repeat containing 61 2.17082
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 2.15265
TMEM176A transmembrane protein 176A 2.15159
KLRG1 killer cell lectin-like receptor subfamily G, member 1 2.14927
RBM19 RNA binding motif protein 19 2.14799
TMEM39B transmembrane protein 39B 2.14678
ACYP2 acylphosphatase 2, muscle type 2.14612
FZD5 frizzled class receptor 5 2.1429
ZNF276 zinc finger protein 276 2.14264
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.14129
SOX2 SRY (sex determining region Y)-box 2 2.12408
PECR peroxisomal trans-2-enoyl-CoA reductase 2.10522
ZNF552 zinc finger protein 552 2.10471
TFCP2L1 transcription factor CP2-like 1 2.10243
RPIA ribose 5-phosphate isomerase A 2.10174
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.09891
SEC31B SEC31 homolog B (S. cerevisiae) 2.09347
TRMT61B tRNA methyltransferase 61B 2.09315
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 2.09212
GRK5 G protein-coupled receptor kinase 5 2.07634
APOA2 apolipoprotein A-II 2.07111
SLC26A6 solute carrier family 26 (anion exchanger), member 6 2.06457
STAT5B signal transducer and activator of transcription 5B 2.05626
TXNL4B thioredoxin-like 4B 2.05418
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2.05109
SCD5 stearoyl-CoA desaturase 5 2.05085
BAG1 BCL2-associated athanogene 2.04109
HROB homologous recombination factor with OB-fold 2.03845
STIM1 stromal interaction molecule 1 2.03767
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.03247
PEG3 paternally expressed 3 2.03149
PPP1R9B protein phosphatase 1, regulatory subunit 9B 2.02737
ACAA1 acetyl-CoA acyltransferase 1 2.02698
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 2.02525
TF transferrin 2.0237
MTSS2 MTSS I-BAR domain containing 2 2.02244
PDE3A phosphodiesterase 3A, cGMP-inhibited 2.01926
ZNF589 zinc finger protein 589 2.01856
HCRT hypocretin (orexin) neuropeptide precursor 2.01612
GDF9 growth differentiation factor 9 2.01039
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 2.00879
GALP galanin-like peptide 2.00779

decreased expression

Symbol Name Standardized Value
ACOT9 acyl-CoA thioesterase 9 -5.48475
KRT14 keratin 14, type I -5.38385
PUF60 poly-U binding splicing factor 60KDa -4.8545
TUBA4A tubulin, alpha 4a -4.8448
TUBB6 tubulin, beta 6 class V -4.67684
MRPS16 mitochondrial ribosomal protein S16 -4.50857
ANXA2 annexin A2 -4.47109
MT2A metallothionein 2A -4.44711
FASTKD5 FAST kinase domains 5 -4.37459
CAPN2 calpain 2, (m/II) large subunit -3.72511
MSN moesin -3.49569
HSPD1 heat shock 60kDa protein 1 (chaperonin) -3.47648
RAB9A RAB9A, member RAS oncogene family -3.33558
UBA1 ubiquitin-like modifier activating enzyme 1 -3.27403
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.00486
BASP1 brain abundant, membrane attached signal protein 1 -2.91154
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.85369
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.83078
USP9X ubiquitin specific peptidase 9, X-linked -2.82647
PUDP pseudouridine 5'-phosphatase -2.74709
SMC1A structural maintenance of chromosomes 1A -2.7143
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.64926
TUBA1C tubulin, alpha 1c -2.52548
ANXA5 annexin A5 -2.48409
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.47403
HSPA1A heat shock 70kDa protein 1A -2.46309
PIR pirin (iron-binding nuclear protein) -2.44962
ADO 2-aminoethanethiol (cysteamine) dioxygenase -2.39138
ZNF7 zinc finger protein 7 -2.35449
KCTD5 potassium channel tetramerization domain containing 5 -2.34086
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.31293
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.30899
MAGED1 melanoma antigen family D1 -2.3069
TUBA1B tubulin, alpha 1b -2.3066
KDM6A lysine (K)-specific demethylase 6A -2.26863
LOC124908558 X antigen family member 1-like -2.257
MAGED2 melanoma antigen family D2 -2.25671
RPN2 ribophorin II -2.25639
CD151 CD151 molecule (Raph blood group) -2.24974
PPARG peroxisome proliferator-activated receptor gamma -2.24167
WDR76 WD repeat domain 76 -2.24165
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -2.239
MT1X metallothionein 1X -2.2306
INPP1 inositol polyphosphate-1-phosphatase -2.22293
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.21666
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -2.21351
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.19813
RNF167 ring finger protein 167 -2.16711
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.16709
LAMB3 laminin, beta 3 -2.1667
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -2.16472
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -2.1598
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -2.15746
STAMBP STAM binding protein -2.1286
EXOSC4 exosome component 4 -2.1212
WDR13 WD repeat domain 13 -2.12002
TM9SF3 transmembrane 9 superfamily member 3 -2.11437
TM9SF2 transmembrane 9 superfamily member 2 -2.10816
LAMC1 laminin, gamma 1 (formerly LAMB2) -2.10304
KIAA0232 KIAA0232 -2.09334
MACIR macrophage immunometabolism regulator -2.07415
PANK4 pantothenate kinase 4 -2.07321
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.07075
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 -2.06498
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.04247
COPB1 coatomer protein complex, subunit beta 1 -2.02583
RBBP7 retinoblastoma binding protein 7 -2.02558
FAM111A family with sequence similarity 111, member A -2.02093
ATF5 activating transcription factor 5 -2.01783
TMSB4X thymosin beta 4, X-linked -2.00844