CRCGN016_MCF10A.TP53.M_24H:M23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimetridazole 32.79 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:M23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.53536
EAPP E2F-associated phosphoprotein 5.26751
RPL39L ribosomal protein L39-like 5.14769
CNRIP1 cannabinoid receptor interacting protein 1 4.49206
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.16819
ZNF586 zinc finger protein 586 4.13279
STX1A syntaxin 1A (brain) 2.87084
AGR2 anterior gradient 2 2.71697
CCNE2 cyclin E2 2.43217
SPTSSA serine palmitoyltransferase, small subunit A 2.39
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.2378
HBB hemoglobin, beta 2.13815
HBA1 hemoglobin, alpha 1 2.13574
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.12215
PFDN1 prefoldin subunit 1 2.11513
ZNF134 zinc finger protein 134 2.11389
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.03608
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.00745

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.63491
KIF14 kinesin family member 14 -4.4766
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.98565
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.50476
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.31546
PDPN podoplanin -2.08906
CLIC4 chloride intracellular channel 4 -2.05706