CRCGN016_MCF10A.TP53.M_24H:N01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzene 98.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:N01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.3809
GATA2 GATA binding protein 2 5.2487
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.83255
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 4.8254
MCOLN1 mucolipin 1 4.8237
STAP2 signal transducing adaptor family member 2 4.79525
ACAA1 acetyl-CoA acyltransferase 1 4.20897
COMP cartilage oligomeric matrix protein 4.0665
SLC38A6 solute carrier family 38, member 6 3.9301
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.1231
PNPLA6 patatin-like phospholipase domain containing 6 3.01845
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.8878
ZNF184 zinc finger protein 184 2.81955
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 2.7621
CGRRF1 cell growth regulator with ring finger domain 1 2.5001
C5 complement component 5 2.4743
DYNLL1 dynein, light chain, LC8-type 1 2.43925
RBBP5 retinoblastoma binding protein 5 2.43715
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.4037
FAM174C family with sequence similarity 174 member C 2.3254
RNF144A ring finger protein 144A 2.2743
SECISBP2 SECIS binding protein 2 2.2635
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.26105
RTF2 replication termination factor 2 2.22755
RABIF RAB interacting factor 2.21935
TRMO tRNA methyltransferase O 2.2094
ADAT1 adenosine deaminase, tRNA-specific 1 2.1886
HLA-DMA major histocompatibility complex, class II, DM alpha 2.1712
HOXA10 homeobox A10 2.14853
MEX3D mex-3 RNA binding family member D 2.1422
PRR7 proline rich 7 (synaptic) 2.1281
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.11475
CNRIP1 cannabinoid receptor interacting protein 1 2.1096
NEMF nuclear export mediator factor 2.0891
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.0873
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 2.07857
ZNF276 zinc finger protein 276 2.06715
MTARC2 mitochondrial amidoxime reducing component 2 2.0627
TPD52L2 tumor protein D52-like 2 2.056
ZNF280D zinc finger protein 280D 2.0133
OBI1 ORC ubiquitin ligase 1 2.00545
TOGARAM1 TOG array regulator of axonemal microtubules 1 2.00215

decreased expression

Symbol Name Standardized Value
ETFB electron-transfer-flavoprotein, beta polypeptide -5.59035
ACOT9 acyl-CoA thioesterase 9 -5.20925
TIMP1 TIMP metallopeptidase inhibitor 1 -4.92175
SGK1 serum/glucocorticoid regulated kinase 1 -3.73145
REEP5 receptor accessory protein 5 -3.57765
MT1X metallothionein 1X -2.92785
PIH1D1 PIH1 domain containing 1 -2.8125
TUBA4A tubulin, alpha 4a -2.7548
KRT14 keratin 14, type I -2.54315
RAP1GAP2 RAP1 GTPase activating protein 2 -2.46735
EXOSC4 exosome component 4 -2.42548
CPE carboxypeptidase E -2.38835
CRYAB crystallin, alpha B -2.3817
PRDX4 peroxiredoxin 4 -2.3576
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.2906
DKKL1 dickkopf-like 1 -2.1094
PCOLCE2 procollagen C-endopeptidase enhancer 2 -2.07455
PRAF2 PRA1 domain family, member 2 -2.0025