CRCGN016_MCF10A.TP53.M_24H:N02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzene 32.77 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

99 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:N02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.62159
TLR4 toll-like receptor 4 3.65727
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.15916
HLA-DRA major histocompatibility complex, class II, DR alpha 2.94917
PRR15L proline rich 15-like 2.90172
KDM5D lysine (K)-specific demethylase 5D 2.899
COMP cartilage oligomeric matrix protein 2.89001
MARCHF1 membrane associated ring-CH-type finger 1 2.85672
CISD1 CDGSH iron sulfur domain 1 2.83399
COL11A1 collagen, type XI, alpha 1 2.78268
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.71668
TLR8 toll-like receptor 8 2.70993
METTL4 methyltransferase like 4 2.69005
TXNL4B thioredoxin-like 4B 2.63466
UBE2D1 ubiquitin-conjugating enzyme E2D 1 2.63299
GHR growth hormone receptor 2.56401
MNDA myeloid cell nuclear differentiation antigen 2.53275
FPR2 formyl peptide receptor 2 2.45806
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.43257
MOK MOK protein kinase 2.38704
PTPRJ protein tyrosine phosphatase, receptor type, J 2.377
TLR1 toll-like receptor 1 2.3759
FFAR2 free fatty acid receptor 2 2.35362
CLEC4A C-type lectin domain family 4, member A 2.34589
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.34133
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.31819
USP9Y ubiquitin specific peptidase 9, Y-linked 2.29427
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.28808
UGDH UDP-glucose 6-dehydrogenase 2.27503
VASP vasodilator-stimulated phosphoprotein 2.2747
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.26865
TTC33 tetratricopeptide repeat domain 33 2.24041
ADAM9 ADAM metallopeptidase domain 9 2.22462
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.2237
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 2.22289
ZNF124 zinc finger protein 124 2.21497
PRR14L proline rich 14-like 2.20493
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.19065
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 2.17089
LDOC1 leucine zipper, down-regulated in cancer 1 2.15425
HAUS3 HAUS augmin-like complex, subunit 3 2.15011
GPR65 G protein-coupled receptor 65 2.14506
CUL5 cullin 5 2.11026
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.09645
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.09551
EDN1 endothelin 1 2.09278
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.08833
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.08594
LDAF1 lipid droplet assembly factor 1 2.08252
RNF19B ring finger protein 19B 2.08072
AOAH acyloxyacyl hydrolase (neutrophil) 2.0791
TMEM176B transmembrane protein 176B 2.07882
SP2 Sp2 transcription factor 2.07657
IGSF6 immunoglobulin superfamily, member 6 2.0754
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 2.06758
SLCO4C1 solute carrier organic anion transporter family, member 4C1 2.06435
SPANXB1 SPANX family, member B1 2.06202
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.05691
GIMAP6 GTPase, IMAP family member 6 2.05324
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 2.04515
CCR1 chemokine (C-C motif) receptor 1 2.04455
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.03957
GRK3 G protein-coupled receptor kinase 3 2.01962
ENOPH1 enolase-phosphatase 1 2.00833

decreased expression

Symbol Name Standardized Value
TUBA4A tubulin, alpha 4a -3.15497
ARFIP2 ADP-ribosylation factor interacting protein 2 -3.12446
ETFB electron-transfer-flavoprotein, beta polypeptide -3.02915
NAP1L4 nucleosome assembly protein 1-like 4 -2.68073
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.67243
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.63421
DDB2 damage-specific DNA binding protein 2, 48kDa -2.62622
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.54148
PLK1 polo-like kinase 1 -2.49294
GFUS GDP-L-fucose synthase -2.45418
RFC2 replication factor C (activator 1) 2, 40kDa -2.44489
OXA1L oxidase (cytochrome c) assembly 1-like -2.44369
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.4278
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.41573
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.36661
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.33575
C1QBP complement component 1, q subcomponent binding protein -2.31294
LAMC2 laminin, gamma 2 -2.31134
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -2.30588
KRT14 keratin 14, type I -2.30459
SMC1A structural maintenance of chromosomes 1A -2.25216
DDIT4 DNA-damage-inducible transcript 4 -2.24834
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.24801
TNIP1 TNFAIP3 interacting protein 1 -2.20398
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.19385
VAT1 vesicle amine transport 1 -2.14849
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.08897
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.08877
UBA1 ubiquitin-like modifier activating enzyme 1 -2.08645
PLD2 phospholipase D2 -2.07809
FGF17 fibroblast growth factor 17 -2.07587
TKT transketolase -2.06025
PIH1D1 PIH1 domain containing 1 -2.04679
GYS1 glycogen synthase 1 (muscle) -2.02763
TFDP1 transcription factor Dp-1 -2.01518