CRCGN016_MCF10A.TP53.M_24H:N03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzene 10.92 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:N03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.27873
UBQLN2 ubiquilin 2 5.22491
SNAP25 synaptosomal-associated protein, 25kDa 4.74525
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 4.38502
MSRA methionine sulfoxide reductase A 4.03201
CRELD2 cysteine-rich with EGF-like domains 2 3.43594
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.27699
WIF1 WNT inhibitory factor 1 2.78483
ACBD3 acyl-CoA binding domain containing 3 2.56359
LYRM1 LYR motif containing 1 2.51999
TOMM34 translocase of outer mitochondrial membrane 34 2.40766
ARHGAP15 Rho GTPase activating protein 15 2.29087
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.2755
GET1 guided entry of tail-anchored proteins factor 1 2.2324
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.09597
SLC38A6 solute carrier family 38, member 6 2.00061

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.45539
CLTB clathrin, light chain B -4.33676
RPIA ribose 5-phosphate isomerase A -4.21124
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.0779
TEX10 testis expressed 10 -3.76029
S100A8 S100 calcium binding protein A8 -3.55144
KRT14 keratin 14, type I -3.37886
BLCAP bladder cancer associated protein -3.35921
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.26859
LYPLA1 lysophospholipase I -3.15723
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.85439
SGK1 serum/glucocorticoid regulated kinase 1 -2.7908
LYPD3 LY6/PLAUR domain containing 3 -2.72279
EIF5 eukaryotic translation initiation factor 5 -2.677
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.55787
ALAS2 5'-aminolevulinate synthase 2 -2.28737
GRN granulin -2.26965
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.24936
STXBP2 syntaxin binding protein 2 -2.24125
TRIB3 tribbles pseudokinase 3 -2.22191
KLK12 kallikrein-related peptidase 12 -2.21489
LGALS7B lectin, galactoside-binding, soluble, 7B -2.19526
PPP1R13L protein phosphatase 1, regulatory subunit 13 like -2.176
SPINK5 serine peptidase inhibitor, Kazal type 5 -2.07873
MAPK3 mitogen-activated protein kinase 3 -2.06956
HBG1 hemoglobin, gamma A -2.06373
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -2.05576
GJB5 gap junction protein, beta 5, 31.1kDa -2.05224
PDZK1IP1 PDZK1 interacting protein 1 -2.00965