CRCGN016_MCF10A.TP53.M_24H:N06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description glycidol 11.26 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

232 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:N06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PEX11A peroxisomal biogenesis factor 11 alpha 5.0855
TRIB1 tribbles pseudokinase 1 4.68214
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 4.67824
COMP cartilage oligomeric matrix protein 4.1882
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.48027
PLSCR1 phospholipid scramblase 1 3.34588
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 3.26275
IGHMBP2 immunoglobulin mu binding protein 2 3.07755
COL11A1 collagen, type XI, alpha 1 2.9701
TXNL4B thioredoxin-like 4B 2.90703
BNC2 basonuclin 2 2.90526
HHEX hematopoietically expressed homeobox 2.77164
ANAPC10 anaphase promoting complex subunit 10 2.7437
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.67247
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.67117
ACAA1 acetyl-CoA acyltransferase 1 2.66971
PDGFRL platelet-derived growth factor receptor-like 2.58279
TRAPPC11 trafficking protein particle complex 11 2.55541
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2.546
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.54532
RNF111 ring finger protein 111 2.51269
NEIL3 nei endonuclease VIII-like 3 (E. coli) 2.50488
PLS3 plastin 3 2.50136
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.47648
ERCC6L excision repair cross-complementation group 6-like 2.4612
ATAD2B ATPase family, AAA domain containing 2B 2.45833
HMG20A high mobility group 20A 2.45701
TTC27 tetratricopeptide repeat domain 27 2.45481
PDZD8 PDZ domain containing 8 2.44615
PCTP phosphatidylcholine transfer protein 2.42245
EMC2 ER membrane protein complex subunit 2 2.39837
NUP54 nucleoporin 54kDa 2.38192
BCCIP BRCA2 and CDKN1A interacting protein 2.37645
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.35595
INCENP inner centromere protein antigens 135/155kDa 2.33289
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.32952
TPO thyroid peroxidase 2.31715
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 2.31107
PDLIM1 PDZ and LIM domain 1 2.3056
SEC24B SEC24 family member B 2.30424
GLT8D2 glycosyltransferase 8 domain containing 2 2.298
ENOPH1 enolase-phosphatase 1 2.27867
EXOC1 exocyst complex component 1 2.26958
TTC26 tetratricopeptide repeat domain 26 2.26407
SBNO1 strawberry notch homolog 1 (Drosophila) 2.2554
KLK13 kallikrein-related peptidase 13 2.25115
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 2.24612
PBX1 pre-B-cell leukemia homeobox 1 2.23629
CENPC centromere protein C 2.23095
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 2.22638
WDR11 WD repeat domain 11 2.22534
GALR3 galanin receptor 3 2.22234
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.22232
ADM2 adrenomedullin 2 2.2194
MELK maternal embryonic leucine zipper kinase 2.21109
SGMS1 sphingomyelin synthase 1 2.2104
NTSR1 neurotensin receptor 1 (high affinity) 2.20481
FSTL1 follistatin-like 1 2.20387
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 2.20216
CDK20 cyclin-dependent kinase 20 2.19317
RNF38 ring finger protein 38 2.19146
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) 2.18661
UBXN8 UBX domain protein 8 2.18273
GRM2 glutamate receptor, metabotropic 2 2.18245
CFAP69 cilia and flagella associated protein 69 2.17478
REV1 REV1, polymerase (DNA directed) 2.1685
ACADSB acyl-CoA dehydrogenase, short/branched chain 2.16566
ZNF518A zinc finger protein 518A 2.14873
ACSM3 acyl-CoA synthetase medium-chain family member 3 2.14404
OR51E2 olfactory receptor, family 51, subfamily E, member 2 2.14386
SMNDC1 survival motor neuron domain containing 1 2.1391
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.13797
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 2.1153
GMEB1 glucocorticoid modulatory element binding protein 1 2.10101
BTN1A1 butyrophilin, subfamily 1, member A1 2.07898
CENPE centromere protein E, 312kDa 2.07865
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 2.07163
CRYZ crystallin, zeta (quinone reductase) 2.07146
PROS1 protein S (alpha) 2.06964
PM20D1 peptidase M20 domain containing 1 2.06485
ZDHHC13 zinc finger, DHHC-type containing 13 2.06219
CDC23 cell division cycle 23 2.0607
NUP155 nucleoporin 155kDa 2.05849
CHSY1 chondroitin sulfate synthase 1 2.05676
COPS4 COP9 signalosome subunit 4 2.05188
PRRX2 paired related homeobox 2 2.05039
CBR4 carbonyl reductase 4 2.04619
HMGB2 high mobility group box 2 2.04602
DNAAF8 dynein axonemal assembly factor 8 2.03841
FAM3C family with sequence similarity 3, member C 2.03757
NME6 NME/NM23 nucleoside diphosphate kinase 6 2.03517
ELF2 E74-like factor 2 (ets domain transcription factor) 2.03335
INHBC inhibin, beta C 2.03288
TMEM131 transmembrane protein 131 2.02374
OBP2B odorant binding protein 2B 2.02109
SPATA5L1 spermatogenesis associated 5-like 1 2.0149
ETFDH electron-transferring-flavoprotein dehydrogenase 2.014
RWDD3 RWD domain containing 3 2.01062

decreased expression

Symbol Name Standardized Value
TUBA4A tubulin, alpha 4a -8.22198
KRT14 keratin 14, type I -5.76217
COTL1 coactosin-like F-actin binding protein 1 -4.93754
ETFB electron-transfer-flavoprotein, beta polypeptide -4.59045
HSPA8 heat shock 70kDa protein 8 -4.55353
TKT transketolase -4.5147
GOLT1B golgi transport 1B -4.13053
DDIT4 DNA-damage-inducible transcript 4 -3.96348
AKT1 v-akt murine thymoma viral oncogene homolog 1 -3.82014
OXA1L oxidase (cytochrome c) assembly 1-like -3.71613
ARFIP2 ADP-ribosylation factor interacting protein 2 -3.63152
GNAS GNAS complex locus -3.63036
ILK integrin-linked kinase -3.48114
TRAPPC3 trafficking protein particle complex 3 -3.46309
WASF3 WAS protein family, member 3 -3.40085
FPGS folylpolyglutamate synthase -3.37371
HSPB1 heat shock 27kDa protein 1 -3.34759
PLK1 polo-like kinase 1 -3.34624
UFM1 ubiquitin-fold modifier 1 -3.26174
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -3.18565
RBM42 RNA binding motif protein 42 -3.10856
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.1028
GFUS GDP-L-fucose synthase -3.09564
ATOX1 antioxidant 1 copper chaperone -3.03587
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.99905
TWF2 twinfilin actin binding protein 2 -2.98873
DOHH deoxyhypusine hydroxylase/monooxygenase -2.95374
PUF60 poly-U binding splicing factor 60KDa -2.92345
TIMP1 TIMP metallopeptidase inhibitor 1 -2.91092
MVP major vault protein -2.90563
BID BH3 interacting domain death agonist -2.90326
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.87505
PNKP polynucleotide kinase 3'-phosphatase -2.83988
TMED9 transmembrane emp24 protein transport domain containing 9 -2.81165
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.77323
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.73947
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.71491
SFXN3 sideroflexin 3 -2.71187
PTK2 protein tyrosine kinase 2 -2.6908
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) -2.68669
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) -2.66516
HMG20B high mobility group 20B -2.66436
CLASRP CLK4-associating serine/arginine rich protein -2.61776
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.61602
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -2.5977
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -2.56989
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -2.56753
COG4 component of oligomeric golgi complex 4 -2.53736
AXIN1 axin 1 -2.53571
NAP1L4 nucleosome assembly protein 1-like 4 -2.4989
MTA1 metastasis associated 1 -2.49225
DGAT1 diacylglycerol O-acyltransferase 1 -2.48141
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -2.4743
NPDC1 neural proliferation, differentiation and control, 1 -2.43323
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -2.43068
TRADD TNFRSF1A-associated via death domain -2.42558
TUBA1B tubulin, alpha 1b -2.42294
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.41529
SYMPK symplekin -2.41124
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.4052
MAP7D1 MAP7 domain containing 1 -2.39298
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.3658
COX5A cytochrome c oxidase subunit Va -2.36493
F8A2 coagulation factor VIII-associated 2 -2.36413
YIPF2 Yip1 domain family, member 2 -2.35319
USF2 upstream transcription factor 2, c-fos interacting -2.34042
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -2.33595
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -2.33313
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -2.33272
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -2.3315
NT5DC2 5'-nucleotidase domain containing 2 -2.32197
TNIP1 TNFAIP3 interacting protein 1 -2.32119
MRPL12 mitochondrial ribosomal protein L12 -2.31872
ATP5F1D ATP synthase F1 subunit delta -2.3169
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.31415
RABAC1 Rab acceptor 1 (prenylated) -2.30887
AMDHD2 amidohydrolase domain containing 2 -2.30811
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.30462
ICAM3 intercellular adhesion molecule 3 -2.3042
PTDSS2 phosphatidylserine synthase 2 -2.30269
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.30265
SAC3D1 SAC3 domain containing 1 -2.29413
MZT2B mitotic spindle organizing protein 2B -2.29146
EEF2 eukaryotic translation elongation factor 2 -2.27664
LRRN3 leucine rich repeat neuronal 3 -2.2677
ACTG1 actin gamma 1 -2.26442
PRKCD protein kinase C, delta -2.24572
TLE5 TLE family member 5, transcriptional modulator -2.24434
KRT17 keratin 17, type I -2.21282
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.2103
S100B S100 calcium binding protein B -2.2086
PACS2 phosphofurin acidic cluster sorting protein 2 -2.20531
VAT1 vesicle amine transport 1 -2.19988
LOC102724594 splicing factor U2AF 35 kDa subunit -2.19943
ECH1 enoyl CoA hydratase 1, peroxisomal -2.19884
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.19797
LAMB3 laminin, beta 3 -2.19782
TBCB tubulin folding cofactor B -2.19736
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -2.18365
CHPF2 chondroitin polymerizing factor 2 -2.16642
PIEZO1 piezo-type mechanosensitive ion channel component 1 -2.15374
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -2.13894
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.1384
IRF3 interferon regulatory factor 3 -2.13719
DDB2 damage-specific DNA binding protein 2, 48kDa -2.13705
MRPL37 mitochondrial ribosomal protein L37 -2.13478
ZIC1 Zic family member 1 -2.13365
TRAF4 TNF receptor-associated factor 4 -2.12632
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 -2.12297
TUBA1C tubulin, alpha 1c -2.11236
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.09571
POTEF POTE ankyrin domain family, member F -2.09009
ERCC1 excision repair cross-complementation group 1 -2.08938
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -2.08275
SEPTIN9 septin 9 -2.08154
ATP5F1B ATP synthase F1 subunit beta -2.07124
VEGFB vascular endothelial growth factor B -2.06748
ZNF219 zinc finger protein 219 -2.06249
APRT adenine phosphoribosyltransferase -2.06053
MRPS2 mitochondrial ribosomal protein S2 -2.05537
CD70 CD70 molecule -2.05257
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.0485
GMPPA GDP-mannose pyrophosphorylase A -2.04045
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.03763
PFN1 profilin 1 -2.03744
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.03501
INPPL1 inositol polyphosphate phosphatase-like 1 -2.03053
TMEM259 transmembrane protein 259 -2.02598
RPL8 ribosomal protein L8 -2.01293
MYBBP1A MYB binding protein (P160) 1a -2.01121
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -2.00959
COX4I1 cytochrome c oxidase subunit IV isoform 1 -2.00822
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.00631
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -2.00408