CRCGN016_MCF10A.TP53.M_24H:N07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitrofural 97.8 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

273 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:N07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PEX11A peroxisomal biogenesis factor 11 alpha 6.20131
DHRS2 dehydrogenase/reductase (SDR family) member 2 4.41556
RNMT RNA (guanine-7-) methyltransferase 3.24358
COMP cartilage oligomeric matrix protein 3.2315
COL11A1 collagen, type XI, alpha 1 3.1513
AGR2 anterior gradient 2 3.11746
FBXO3 F-box protein 3 3.03909
TGFB3 transforming growth factor, beta 3 2.82862
CADM1 cell adhesion molecule 1 2.82501
MBNL3 muscleblind-like splicing regulator 3 2.77961
TOMM34 translocase of outer mitochondrial membrane 34 2.75838
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2.72978
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 2.71351
SNAP25 synaptosomal-associated protein, 25kDa 2.69626
AP3M2 adaptor-related protein complex 3, mu 2 subunit 2.66946
ADAM9 ADAM metallopeptidase domain 9 2.64212
ENOPH1 enolase-phosphatase 1 2.62358
RNF103-CHMP3 RNF103-CHMP3 readthrough 2.6216
LIPT1 lipoyltransferase 1 2.6211
FBXO34 F-box protein 34 2.61079
SECISBP2 SECIS binding protein 2 2.61001
MMP2 matrix metallopeptidase 2 2.60136
CCDC25 coiled-coil domain containing 25 2.59138
CEP192 centrosomal protein 192kDa 2.58663
METTL18 methyltransferase like 18 2.56891
CCP110 centriolar coiled coil protein 110kDa 2.53901
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 2.53171
SPIN2B spindlin family, member 2B 2.51419
GPN1 GPN-loop GTPase 1 2.50359
TIMP2 TIMP metallopeptidase inhibitor 2 2.4984
RLN2 relaxin 2 2.48853
DAZL deleted in azoospermia-like 2.48352
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 2.4816
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 2.45128
DET1 de-etiolated homolog 1 (Arabidopsis) 2.42803
DDN dendrin 2.41524
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 2.41388
COPS4 COP9 signalosome subunit 4 2.40034
UBXN8 UBX domain protein 8 2.39778
MCFD2 multiple coagulation factor deficiency 2 2.39736
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.38827
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough 2.38314
ZNF260 zinc finger protein 260 2.38291
GTF2B general transcription factor IIB 2.38211
TRAPPC11 trafficking protein particle complex 11 2.35986
GET1 guided entry of tail-anchored proteins factor 1 2.34405
AGK acylglycerol kinase 2.34087
NID2 nidogen 2 (osteonidogen) 2.33914
EXTL2 exostosin-like glycosyltransferase 2 2.33629
TMEM50A transmembrane protein 50A 2.33319
OMD osteomodulin 2.32832
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 2.32499
VPS33B vacuolar protein sorting 33 homolog B (yeast) 2.32017
LYRM1 LYR motif containing 1 2.31536
DPYD dihydropyrimidine dehydrogenase 2.31325
METTL4 methyltransferase like 4 2.30752
DSG2 desmoglein 2 2.28085
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 2.27737
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 2.27425
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.2446
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 2.24174
GLOD4 glyoxalase domain containing 4 2.23932
ZNF518A zinc finger protein 518A 2.21584
NUP54 nucleoporin 54kDa 2.21522
PDGFRL platelet-derived growth factor receptor-like 2.20567
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2.19014
STXBP3 syntaxin binding protein 3 2.19004
PDLIM3 PDZ and LIM domain 3 2.18033
STEAP1 six transmembrane epithelial antigen of the prostate 1 2.1712
NFIL3 nuclear factor, interleukin 3 regulated 2.1637
FUBP3 far upstream element (FUSE) binding protein 3 2.15193
FIRRM FIGNL1 interacting regulator of recombination and mitosis 2.13526
EBAG9 estrogen receptor binding site associated, antigen, 9 2.13235
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 2.13139
TEX30 testis expressed 30 2.12889
SPANXB1 SPANX family, member B1 2.12454
SETD6 SET domain containing 6 2.1239
ZNF514 zinc finger protein 514 2.11922
MEAF6 MYST/Esa1-associated factor 6 2.11632
ERMAP erythroblast membrane-associated protein (Scianna blood group) 2.11373
TDRD12 tudor domain containing 12 2.11338
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 2.10862
AIRIM AFG2 interacting ribosome maturation factor 2.10589
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.10438
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 2.10337
ELF2 E74-like factor 2 (ets domain transcription factor) 2.10319
ATMIN ATM interactor 2.09032
PLS1 plastin 1 2.09031
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 2.08858
THAP10 THAP domain containing 10 2.08692
DPH2 DPH2 homolog (S. cerevisiae) 2.07905
CPED1 cadherin-like and PC-esterase domain containing 1 2.07632
LPIN2 lipin 2 2.07552
COIL coilin 2.07542
ZNF23 zinc finger protein 23 2.07303
THNSL1 threonine synthase-like 1 (S. cerevisiae) 2.073
THUMPD1 THUMP domain containing 1 2.07124
CRIPT cysteine-rich PDZ-binding protein 2.06868
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.06261
ASTN1 astrotactin 1 2.05847
RAP2C RAP2C, member of RAS oncogene family 2.05814
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 2.05784
NANOS3 nanos homolog 3 (Drosophila) 2.05421
TIPRL TOR signaling pathway regulator 2.05074
CRNKL1 crooked neck pre-mRNA splicing factor 1 2.04746
DENND4A DENN/MADD domain containing 4A 2.047
GHR growth hormone receptor 2.04466
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 2.04402
LRRC40 leucine rich repeat containing 40 2.03952
TTI1 TELO2 interacting protein 1 2.03783
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 2.03748
CD58 CD58 molecule 2.03712
SDHAF3 succinate dehydrogenase complex assembly factor 3 2.03611
CILK1 ciliogenesis associated kinase 1 2.03608
TOPBP1 topoisomerase (DNA) II binding protein 1 2.0351
BBS10 Bardet-Biedl syndrome 10 2.03069
TZMP1 transition zone microprotein 1 2.03015
TM2D1 TM2 domain containing 1 2.02566
H2AJ H2A.J histone 2.02329
USPL1 ubiquitin specific peptidase like 1 2.02266
BCAP29 B-cell receptor-associated protein 29 2.02111
PHF14 PHD finger protein 14 2.01984
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 2.01454
RHOBTB1 Rho-related BTB domain containing 1 2.0126
POT1 protection of telomeres 1 2.00999
TPO thyroid peroxidase 2.00866
TBPL1 TBP-like 1 2.00485
SNX4 sorting nexin 4 2.00347

decreased expression

Symbol Name Standardized Value
TUBA4A tubulin, alpha 4a -7.3689
KRT14 keratin 14, type I -7.16766
RNF167 ring finger protein 167 -5.19298
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.98466
PFN1 profilin 1 -3.96195
HSPB1 heat shock 27kDa protein 1 -3.90037
COTL1 coactosin-like F-actin binding protein 1 -3.68373
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -3.66249
ARFIP2 ADP-ribosylation factor interacting protein 2 -3.63102
CD81 CD81 molecule -3.60566
CHMP4B charged multivesicular body protein 4B -3.58407
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.58287
DDIT4 DNA-damage-inducible transcript 4 -3.49768
MT1X metallothionein 1X -3.47209
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -3.46338
TWF2 twinfilin actin binding protein 2 -3.43894
ETFB electron-transfer-flavoprotein, beta polypeptide -3.39269
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -3.38465
PUF60 poly-U binding splicing factor 60KDa -3.35865
TKT transketolase -3.34113
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -3.26479
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -3.23508
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.2315
ANXA2 annexin A2 -3.2315
GFUS GDP-L-fucose synthase -3.18178
ECH1 enoyl CoA hydratase 1, peroxisomal -3.13277
DDB2 damage-specific DNA binding protein 2, 48kDa -3.10083
ADGRE5 adhesion G protein-coupled receptor E5 -3.09197
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -3.06297
MSN moesin -3.04505
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.03619
FPGS folylpolyglutamate synthase -3.00128
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.94122
AP2M1 adaptor-related protein complex 2, mu 1 subunit -2.91383
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.86291
PGAM4 phosphoglycerate mutase family member 4 -2.83206
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.81948
C1QBP complement component 1, q subcomponent binding protein -2.81054
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.77978
INTS3 integrator complex subunit 3 -2.7734
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.76938
MRPL30 mitochondrial ribosomal protein L30 -2.76528
CDCA4 cell division cycle associated 4 -2.72208
BCKDK branched chain ketoacid dehydrogenase kinase -2.69545
CABIN1 calcineurin binding protein 1 -2.69429
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -2.68417
EXOSC4 exosome component 4 -2.6836
CCDC86 coiled-coil domain containing 86 -2.65158
RBM42 RNA binding motif protein 42 -2.62363
SORBS3 sorbin and SH3 domain containing 3 -2.61965
CSK c-src tyrosine kinase -2.61407
PNKP polynucleotide kinase 3'-phosphatase -2.61096
MRPL12 mitochondrial ribosomal protein L12 -2.60841
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.60534
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 -2.57837
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.57179
TNIP1 TNFAIP3 interacting protein 1 -2.56498
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.56069
LRP10 low density lipoprotein receptor-related protein 10 -2.54794
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.53391
NUCB1 nucleobindin 1 -2.53379
BRMS1L breast cancer metastasis-suppressor 1-like -2.53178
EMC9 ER membrane protein complex subunit 9 -2.51316
USF2 upstream transcription factor 2, c-fos interacting -2.50094
NAP1L4 nucleosome assembly protein 1-like 4 -2.49742
LOC112694756 uncharaterized LOC112694756 -2.49616
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.48881
MT2A metallothionein 2A -2.48794
OXA1L oxidase (cytochrome c) assembly 1-like -2.48379
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.47915
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.47611
PLK1 polo-like kinase 1 -2.47376
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -2.47155
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.44168
ACTN4 actinin, alpha 4 -2.43255
PMVK phosphomevalonate kinase -2.42774
ATP5F1D ATP synthase F1 subunit delta -2.4258
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.42218
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha -2.4113
DDB1 damage-specific DNA binding protein 1, 127kDa -2.4107
MRPS2 mitochondrial ribosomal protein S2 -2.4015
GYS1 glycogen synthase 1 (muscle) -2.39786
CAPNS1 calpain, small subunit 1 -2.39552
MRPS16 mitochondrial ribosomal protein S16 -2.38593
GMPPB GDP-mannose pyrophosphorylase B -2.37717
MVP major vault protein -2.36232
PIH1D1 PIH1 domain containing 1 -2.35219
CASZ1 castor zinc finger 1 -2.329
REXO2 RNA exonuclease 2 -2.32778
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -2.32379
CALR calreticulin -2.31632
NHP2 NHP2 ribonucleoprotein -2.31582
ILK integrin-linked kinase -2.29718
AMDHD2 amidohydrolase domain containing 2 -2.29594
MICALL1 MICAL-like 1 -2.29585
NUDC nudC nuclear distribution protein -2.2825
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.26911
IRF3 interferon regulatory factor 3 -2.26193
FARSA phenylalanyl-tRNA synthetase, alpha subunit -2.2613
TMED9 transmembrane emp24 protein transport domain containing 9 -2.2594
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -2.25922
GSTP1 glutathione S-transferase pi 1 -2.2546
VAT1 vesicle amine transport 1 -2.25226
BAX BCL2-associated X protein -2.24626
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -2.24293
PRPF19 pre-mRNA processing factor 19 -2.24287
DOHH deoxyhypusine hydroxylase/monooxygenase -2.23632
ERCC2 excision repair cross-complementation group 2 -2.22828
EFNA3 ephrin-A3 -2.22824
RANGAP1 Ran GTPase activating protein 1 -2.22046
MYBBP1A MYB binding protein (P160) 1a -2.21717
ATOX1 antioxidant 1 copper chaperone -2.21226
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.20789
BASP1 brain abundant, membrane attached signal protein 1 -2.2047
P4HB prolyl 4-hydroxylase, beta polypeptide -2.20064
PTBP1 polypyrimidine tract binding protein 1 -2.16943
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -2.1557
CNN2 calponin 2 -2.13632
CUEDC2 CUE domain containing 2 -2.12597
TSPO translocator protein (18kDa) -2.12315
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -2.11948
RNF126 ring finger protein 126 -2.1188
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -2.11821
CIRBP cold inducible RNA binding protein -2.11465
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -2.10759
NT5C 5', 3'-nucleotidase, cytosolic -2.10395
CLTB clathrin, light chain B -2.09801
ARMC6 armadillo repeat containing 6 -2.09716
PRRC2A proline-rich coiled-coil 2A -2.09067
PTGES2 prostaglandin E synthase 2 -2.09043
CLPTM1 cleft lip and palate associated transmembrane protein 1 -2.08441
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 -2.07758
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -2.06819
MZT2B mitotic spindle organizing protein 2B -2.06418
UBA1 ubiquitin-like modifier activating enzyme 1 -2.05847
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B -2.0568
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -2.04893
HRAS Harvey rat sarcoma viral oncogene homolog -2.04725
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.0413
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa -2.03526
GRN granulin -2.0351
SCARB1 scavenger receptor class B, member 1 -2.0271
TRIM28 tripartite motif containing 28 -2.01936
GPS1 G protein pathway suppressor 1 -2.01775
NCLN nicalin -2.00349