CRCGN016_MCF10A.TP53.M_24H:N08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitrofural 32.6 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:N08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 7.29578
KDM5A lysine (K)-specific demethylase 5A 4.77838
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 4.50516
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.86394
CXCL3 chemokine (C-X-C motif) ligand 3 3.80636
E2F2 E2F transcription factor 2 3.44514
CORO1A coronin, actin binding protein, 1A 2.9252
COMP cartilage oligomeric matrix protein 2.89981
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.64687
LYRM1 LYR motif containing 1 2.56892
NINJ2 ninjurin 2 2.51904
CETN3 centrin, EF-hand protein, 3 2.51639
MAP7 microtubule-associated protein 7 2.50545
FBXL4 F-box and leucine-rich repeat protein 4 2.44534
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like 2.29914
ANO10 anoctamin 10 2.11564
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 2.11166
WNK1 WNK lysine deficient protein kinase 1 2.09146
RAP2A RAP2A, member of RAS oncogene family 2.06141
COMMD9 COMM domain containing 9 2.03148
CISD1 CDGSH iron sulfur domain 1 2.02046
CADM1 cell adhesion molecule 1 2.01992
MCMBP minichromosome maintenance complex binding protein 2.01321

decreased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 -3.30019
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.24176
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.22704
ETFB electron-transfer-flavoprotein, beta polypeptide -3.21137
ARFIP2 ADP-ribosylation factor interacting protein 2 -3.17079
KIF14 kinesin family member 14 -3.14339
TUBA4A tubulin, alpha 4a -3.12599
MT2A metallothionein 2A -3.10164
ANXA2 annexin A2 -3.06026
LDHD lactate dehydrogenase D -2.8231
TUBB6 tubulin, beta 6 class V -2.65454
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.61694
PNKP polynucleotide kinase 3'-phosphatase -2.52221
TWF2 twinfilin actin binding protein 2 -2.50711
ELAC2 elaC ribonuclease Z 2 -2.498
GPS1 G protein pathway suppressor 1 -2.46132
RUVBL1 RuvB-like AAA ATPase 1 -2.4312
S100A8 S100 calcium binding protein A8 -2.4263
BAG3 BCL2-associated athanogene 3 -2.41384
HSPB1 heat shock 27kDa protein 1 -2.35875
FPGS folylpolyglutamate synthase -2.34681
GFUS GDP-L-fucose synthase -2.28934
CBR1 carbonyl reductase 1 -2.2815
LOC112694756 uncharaterized LOC112694756 -2.23589
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.23333
CBR3 carbonyl reductase 3 -2.20189
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.19228
MVP major vault protein -2.15091
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.13581
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.13206
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.08276
S100A4 S100 calcium binding protein A4 -2.06127
MT1X metallothionein 1X -2.05763
TUFM Tu translation elongation factor, mitochondrial -2.02607
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.00123