CRCGN016_MCF10A.TP53.M_24H:N11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description urethane 35.1 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

110 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:N11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EML3 echinoderm microtubule associated protein like 3 5.1608
CADM1 cell adhesion molecule 1 4.19268
RAB31 RAB31, member RAS oncogene family 3.28943
COMP cartilage oligomeric matrix protein 2.94015
ACBD3 acyl-CoA binding domain containing 3 2.65357
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 2.61205
HBB hemoglobin, beta 2.57944
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.57932
COL11A1 collagen, type XI, alpha 1 2.56338
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2.51896
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.50857
MTFR1 mitochondrial fission regulator 1 2.47129
RNF38 ring finger protein 38 2.4055
MORC3 MORC family CW-type zinc finger 3 2.30782
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.30758
PTN pleiotrophin 2.30287
LUC7L2 LUC7-like 2 (S. cerevisiae) 2.30126
COPS7A COP9 signalosome subunit 7A 2.28231
INTS8 integrator complex subunit 8 2.27857
SECISBP2 SECIS binding protein 2 2.22697
BIRC2 baculoviral IAP repeat containing 2 2.22003
PLA2G12A phospholipase A2, group XIIA 2.20605
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.20535
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 2.16674
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.16411
NOL9 nucleolar protein 9 2.14521
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.13239
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase 2.13018
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 2.12994
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 2.12749
TOMM34 translocase of outer mitochondrial membrane 34 2.11517
RANBP2 RAN binding protein 2 2.08528
FMOD fibromodulin 2.04284
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.02415
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 2.01221
PARP12 poly (ADP-ribose) polymerase family, member 12 2.01207

decreased expression

Symbol Name Standardized Value
BID BH3 interacting domain death agonist -5.00951
CD58 CD58 molecule -4.87937
ETFB electron-transfer-flavoprotein, beta polypeptide -4.27766
GRWD1 glutamate-rich WD repeat containing 1 -4.16488
NR2F6 nuclear receptor subfamily 2, group F, member 6 -4.10972
ENOPH1 enolase-phosphatase 1 -3.92834
PFN1 profilin 1 -3.8286
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.74432
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.6583
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.65369
DDIT4 DNA-damage-inducible transcript 4 -3.65186
DNM1L dynamin 1-like -3.60134
CHMP4B charged multivesicular body protein 4B -3.56455
ARFIP2 ADP-ribosylation factor interacting protein 2 -3.32889
C1QBP complement component 1, q subcomponent binding protein -3.32319
HSPB1 heat shock 27kDa protein 1 -3.25866
TKT transketolase -3.21897
MVP major vault protein -3.21308
SQSTM1 sequestosome 1 -3.20276
GFUS GDP-L-fucose synthase -3.04764
TWF2 twinfilin actin binding protein 2 -2.9745
TUBA4A tubulin, alpha 4a -2.94793
PIH1D1 PIH1 domain containing 1 -2.87865
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -2.78019
MPST mercaptopyruvate sulfurtransferase -2.71462
FPGS folylpolyglutamate synthase -2.7052
NPDC1 neural proliferation, differentiation and control, 1 -2.69074
NQO1 NAD(P)H dehydrogenase, quinone 1 -2.65773
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.61905
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.60827
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.55905
PEAK1 pseudopodium-enriched atypical kinase 1 -2.55274
MT1X metallothionein 1X -2.55031
OCEL1 occludin/ELL domain containing 1 -2.50705
PGLS 6-phosphogluconolactonase -2.50438
STX10 syntaxin 10 -2.50219
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 -2.4292
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.41968
TMED1 transmembrane emp24 protein transport domain containing 1 -2.41037
PPP6R1 protein phosphatase 6, regulatory subunit 1 -2.39902
EFNA3 ephrin-A3 -2.35817
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.30749
HRAS Harvey rat sarcoma viral oncogene homolog -2.27065
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent -2.26949
PRKCD protein kinase C, delta -2.25893
SMG6 SMG6 nonsense mediated mRNA decay factor -2.2538
RHOG ras homolog family member G -2.24846
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.23981
MAP1S microtubule-associated protein 1S -2.23918
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.23017
DPP3 dipeptidyl-peptidase 3 -2.16456
ZNF219 zinc finger protein 219 -2.15719
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -2.1508
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.14796
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.14541
ECE1 endothelin converting enzyme 1 -2.14002
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -2.13101
COG4 component of oligomeric golgi complex 4 -2.1275
BAK1 BCL2-antagonist/killer 1 -2.12293
TIMP1 TIMP metallopeptidase inhibitor 1 -2.08713
BICRA BRD4 interacting chromatin remodeling complex associated protein -2.08035
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.07429
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) -2.07012
MST1R macrophage stimulating 1 receptor -2.06144
PRB2 proline-rich protein BstNI subfamily 2 -2.06074
FOXJ1 forkhead box J1 -2.0607
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.05999
DOHH deoxyhypusine hydroxylase/monooxygenase -2.04198
FRS2 fibroblast growth factor receptor substrate 2 -2.03854
CSK c-src tyrosine kinase -2.03808
BBC3 BCL2 binding component 3 -2.0289
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -2.02522
RAB8B RAB8B, member RAS oncogene family -2.01351
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 -2.01207