CRCGN016_MCF10A.TP53.M_24H:N22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description medroxyprogesterone 99.12 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

90 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:N22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5.29572
EAPP E2F-associated phosphoprotein 4.47812
STK10 serine/threonine kinase 10 4.09488
CADM1 cell adhesion molecule 1 3.76749
CXCR4 chemokine (C-X-C motif) receptor 4 3.56531
ALDOC aldolase C, fructose-bisphosphate 3.22319
FHL2 four and a half LIM domains 2 3.02643
MCUR1 mitochondrial calcium uniporter regulator 1 2.99219
KDM5D lysine (K)-specific demethylase 5D 2.96419
GLRX glutaredoxin (thioltransferase) 2.93922
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.93566
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.80013
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.7312
ARHGAP5 Rho GTPase activating protein 5 2.62988
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.62583
HMGA2 high mobility group AT-hook 2 2.56501
AARS1 alanyl-tRNA synthetase 1 2.5041
WASF3 WAS protein family, member 3 2.41636
DENND2D DENN/MADD domain containing 2D 2.34015
COL1A2 collagen, type I, alpha 2 2.33101
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.28944
ACBD3 acyl-CoA binding domain containing 3 2.28198
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.26898
SPTSSA serine palmitoyltransferase, small subunit A 2.25883
SRP54 signal recognition particle 54kDa 2.20823
KIFBP kinesin family binding protein 2.18899
ADA2 adenosine deaminase 2 2.15381
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 2.10975
FKBP10 FK506 binding protein 10, 65 kDa 2.09902
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 2.09798
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.09439
DPH2 DPH2 homolog (S. cerevisiae) 2.07879
DOCK2 dedicator of cytokinesis 2 2.07173
COL3A1 collagen, type III, alpha 1 2.05438
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 2.05419
PSIP1 PC4 and SFRS1 interacting protein 1 2.04527
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.03798
SQLE squalene epoxidase 2.00386

decreased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A -5.64565
GRWD1 glutamate-rich WD repeat containing 1 -5.50638
ACOT9 acyl-CoA thioesterase 9 -5.13178
CD320 CD320 molecule -4.79353
ADRB2 adrenoceptor beta 2, surface -4.54858
ANXA2 annexin A2 -3.95725
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.89939
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.71853
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.23677
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -3.02764
RGS2 regulator of G-protein signaling 2 -2.8308
SMC1A structural maintenance of chromosomes 1A -2.79996
PRR15L proline rich 15-like -2.68447
PRDX4 peroxiredoxin 4 -2.61576
ADI1 acireductone dioxygenase 1 -2.60275
PIH1D1 PIH1 domain containing 1 -2.59103
NLRP2B NLR family pyrin domain containing 2B -2.58344
PRPF31 pre-mRNA processing factor 31 -2.55824
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.55398
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.50689
MCMBP minichromosome maintenance complex binding protein -2.48813
XPO7 exportin 7 -2.43977
TXNL4B thioredoxin-like 4B -2.41904
ZNF35 zinc finger protein 35 -2.35086
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.26975
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) -2.26523
BIRC5 baculoviral IAP repeat containing 5 -2.22973
NOSIP nitric oxide synthase interacting protein -2.19558
GINS4 GINS complex subunit 4 (Sld5 homolog) -2.1696
EXOSC4 exosome component 4 -2.16954
KANK3 KN motif and ankyrin repeat domains 3 -2.16284
AOPEP aminopeptidase O (putative) -2.14975
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.14849
AURKB aurora kinase B -2.14531
C1QBP complement component 1, q subcomponent binding protein -2.14134
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -2.11967
TWF2 twinfilin actin binding protein 2 -2.11606
R3HCC1 R3H domain and coiled-coil containing 1 -2.0993
NFIL3 nuclear factor, interleukin 3 regulated -2.09628
RNASE7 ribonuclease, RNase A family, 7 -2.09352
ILF2 interleukin enhancer binding factor 2 -2.06471
TMEM160 transmembrane protein 160 -2.06304
GPS1 G protein pathway suppressor 1 -2.05509
ELAC2 elaC ribonuclease Z 2 -2.03781
MCM3 minichromosome maintenance complex component 3 -2.02925
MRM3 mitochondrial rRNA methyltransferase 3 -2.02844
HPCA hippocalcin -2.01854
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.01383
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.01168
STMN1 stathmin 1 -2.00578
INTS5 integrator complex subunit 5 -2.00276
BAG1 BCL2-associated athanogene -2.00074