CRCGN016_MCF10A.TP53.M_24H:N23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description medroxyprogesterone 33.04 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

100 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:N23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.24925
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.11869
SPAG4 sperm associated antigen 4 4.02784
AMDHD2 amidohydrolase domain containing 2 4.01416
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 3.99715
ACAA1 acetyl-CoA acyltransferase 1 3.89345
PDGFRL platelet-derived growth factor receptor-like 3.07567
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.9517
HBA1 hemoglobin, alpha 1 2.93271
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.70186
SIX1 SIX homeobox 1 2.53842
FHL2 four and a half LIM domains 2 2.53744
ALDOC aldolase C, fructose-bisphosphate 2.5182
VAMP7 vesicle-associated membrane protein 7 2.43786
LGMN legumain 2.38266
CRY2 cryptochrome circadian clock 2 2.34827
DNMBP dynamin binding protein 2.33351
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.31649
YBX3 Y box binding protein 3 2.23628
ZC2HC1A zinc finger, C2HC-type containing 1A 2.22773
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 2.19403
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 2.19281
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.18629
INSIG1 insulin induced gene 1 2.15845
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.14522
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 2.11115
SOAT2 sterol O-acyltransferase 2 2.06432
COMP cartilage oligomeric matrix protein 2.04062
EFR3A EFR3 homolog A (S. cerevisiae) 2.03341
SPG11 spastic paraplegia 11 (autosomal recessive) 2.01518
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2.01232
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 2.00853
ISLR immunoglobulin superfamily containing leucine-rich repeat 2.00459
SPAG1 sperm associated antigen 1 2.00136

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -4.41608
HSPA8 heat shock 70kDa protein 8 -4.27821
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.09156
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.03303
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.89117
PFN1 profilin 1 -3.88473
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.86739
KRT14 keratin 14, type I -3.7614
CAB39 calcium binding protein 39 -3.60067
NLRP4 NLR family, pyrin domain containing 4 -3.5177
JMJD6 jumonji domain containing 6 -3.45484
UFM1 ubiquitin-fold modifier 1 -3.34142
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.07428
C1QBP complement component 1, q subcomponent binding protein -2.92671
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.8943
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.78298
RPL38 ribosomal protein L38 -2.78069
HSPA1A heat shock 70kDa protein 1A -2.67168
GRWD1 glutamate-rich WD repeat containing 1 -2.62646
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -2.59654
TWF2 twinfilin actin binding protein 2 -2.52209
NME2 NME/NM23 nucleoside diphosphate kinase 2 -2.50767
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.49227
ZNF446 zinc finger protein 446 -2.41047
TSPOAP1 TSPO associated protein 1 -2.40738
TUBA4A tubulin, alpha 4a -2.37221
EIF3G eukaryotic translation initiation factor 3, subunit G -2.37066
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -2.34301
DTD1 D-tyrosyl-tRNA deacylase 1 -2.33588
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -2.31417
DDIT4 DNA-damage-inducible transcript 4 -2.28869
ZNHIT3 zinc finger, HIT-type containing 3 -2.27756
CSK c-src tyrosine kinase -2.24536
RPS15A ribosomal protein S15a -2.22907
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -2.22752
RBM34 RNA binding motif protein 34 -2.22696
HSPH1 heat shock 105kDa/110kDa protein 1 -2.22499
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.22247
EIF3H eukaryotic translation initiation factor 3, subunit H -2.18354
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -2.18283
MUS81 MUS81 structure-specific endonuclease subunit -2.15437
TMEM47 transmembrane protein 47 -2.13529
TBCC tubulin folding cofactor C -2.12364
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -2.11839
RGS2 regulator of G-protein signaling 2 -2.11785
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.10694
SNX6 sorting nexin 6 -2.10164
DDRGK1 DDRGK domain containing 1 -2.08731
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 -2.06888
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -2.06319
TMEM230 transmembrane protein 230 -2.0622
ZNF426 zinc finger protein 426 -2.06023
MRPS31 mitochondrial ribosomal protein S31 -2.05504
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.05035
RPL3 ribosomal protein L3 -2.04409
KANSL1L KAT8 regulatory NSL complex subunit 1-like -2.0412
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.03946
CAB39L calcium binding protein 39-like -2.0279
RPL21 ribosomal protein L21 -2.02702
BGLAP bone gamma-carboxyglutamate (gla) protein -2.0267
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.02315
HSPE1 heat shock 10kDa protein 1 -2.02185
RPS7 ribosomal protein S7 -2.02053
RPL39 ribosomal protein L39 -2.0185
ACTG1 actin gamma 1 -2.01291
ZNF665 zinc finger protein 665 -2.00156