CRCGN016_MCF10A.TP53.M_24H:N24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description medroxyprogesterone 11.01 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

333 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:N24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 5.86995
LGMN legumain 4.9253
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 4.80619
CNRIP1 cannabinoid receptor interacting protein 1 4.56068
TSEN2 TSEN2 tRNA splicing endonuclease subunit 4.54433
ABHD4 abhydrolase domain containing 4 4.52404
SLC35B1 solute carrier family 35, member B1 4.48896
MAP7 microtubule-associated protein 7 4.29311
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 4.07645
C5 complement component 5 3.82029
LYN LYN proto-oncogene, Src family tyrosine kinase 3.64145
ZMIZ1 zinc finger, MIZ-type containing 1 3.34846
WDR7 WD repeat domain 7 3.34588
GTPBP8 GTP-binding protein 8 (putative) 3.29476
ZNF587 zinc finger protein 587 3.25925
DENND2D DENN/MADD domain containing 2D 3.11448
CNTNAP1 contactin associated protein 1 3.07731
MLEC malectin 3.0758
TLR4 toll-like receptor 4 3.04506
SPDEF SAM pointed domain containing ETS transcription factor 3.02485
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 3.00442
ZNF589 zinc finger protein 589 2.98944
PLA2G15 phospholipase A2, group XV 2.98801
SYK spleen tyrosine kinase 2.95882
SCD5 stearoyl-CoA desaturase 5 2.95073
DRC4 dynein regulatory complex subunit 4 2.93355
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.92293
STX1A syntaxin 1A (brain) 2.91675
DPP6 dipeptidyl-peptidase 6 2.88628
LUZP2 leucine zipper protein 2 2.85768
ZNF587B zinc finger protein 587B 2.85455
SPRY4 sprouty homolog 4 (Drosophila) 2.84307
TTC28 tetratricopeptide repeat domain 28 2.83581
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.82014
KDM3A lysine (K)-specific demethylase 3A 2.78763
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 2.75909
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.75796
NCBP3 nuclear cap binding subunit 3 2.72235
RAB27A RAB27A, member RAS oncogene family 2.71666
FAM124B family with sequence similarity 124B 2.71301
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.70292
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 2.7014
TOPBP1 topoisomerase (DNA) II binding protein 1 2.69808
LXN latexin 2.68239
TRPV1 transient receptor potential cation channel, subfamily V, member 1 2.6571
CFAP44 cilia and flagella associated protein 44 2.65686
TMCC1 transmembrane and coiled-coil domain family 1 2.65624
OLFML2A olfactomedin-like 2A 2.64689
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 2.61901
SNX7 sorting nexin 7 2.59778
CLEC7A C-type lectin domain family 7, member A 2.57582
MINDY1 MINDY lysine 48 deubiquitinase 1 2.57269
BMP4 bone morphogenetic protein 4 2.5687
TP53BP2 tumor protein p53 binding protein 2 2.53811
IGSF6 immunoglobulin superfamily, member 6 2.52722
SOX2 SRY (sex determining region Y)-box 2 2.49289
THSD7A thrombospondin, type I, domain containing 7A 2.49217
LY75-CD302 LY75-CD302 readthrough 2.49008
TMEM268 transmembrane protein 268 2.48162
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 2.47619
ODAD2 outer dynein arm docking complex subunit 2 2.47435
PSME3IP1 proteasome activator subunit 3 interacting protein 1 2.46624
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.46246
GRIA3 glutamate receptor, ionotropic, AMPA 3 2.45275
TMEM101 transmembrane protein 101 2.44811
MAPK10 mitogen-activated protein kinase 10 2.43972
APOE apolipoprotein E 2.43927
SENP7 SUMO1/sentrin specific peptidase 7 2.43337
MAP2K6 mitogen-activated protein kinase kinase 6 2.42957
FAM174B family with sequence similarity 174, member B 2.42405
ATAD2B ATPase family, AAA domain containing 2B 2.41651
CLCN6 chloride channel, voltage-sensitive 6 2.4129
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.41073
STRA6 stimulated by retinoic acid 6 2.3953
ZNF551 zinc finger protein 551 2.39428
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.39229
ATL2 atlastin GTPase 2 2.38996
MZF1 myeloid zinc finger 1 2.38527
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.37291
ZNF510 zinc finger protein 510 2.37057
ZNF93 zinc finger protein 93 2.3672
WDR45B WD repeat domain 45B 2.36466
IFFO1 intermediate filament family orphan 1 2.35002
ZNF26 zinc finger protein 26 2.33801
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2.33784
OR7C2 olfactory receptor, family 7, subfamily C, member 2 2.33609
RET ret proto-oncogene 2.33202
PLEKHS1 pleckstrin homology domain containing, family S member 1 2.33184
KIF1A kinesin family member 1A 2.32943
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.3293
NASP nuclear autoantigenic sperm protein (histone-binding) 2.32435
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 2.32356
IRF8 interferon regulatory factor 8 2.3209
FMO1 flavin containing monooxygenase 1 2.31998
UNC13A unc-13 homolog A (C. elegans) 2.31888
NANOG Nanog homeobox 2.3135
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.3129
BCL2 B-cell CLL/lymphoma 2 2.31171
WEE1 WEE1 G2 checkpoint kinase 2.31072
FAM131B family with sequence similarity 131, member B 2.31067
ADGRA2 adhesion G protein-coupled receptor A2 2.30714
ZNF135 zinc finger protein 135 2.30391
ZNF107 zinc finger protein 107 2.29672
PLXDC1 plexin domain containing 1 2.29527
MARCKS myristoylated alanine-rich protein kinase C substrate 2.29519
PHC1 polyhomeotic homolog 1 (Drosophila) 2.29275
GOLGA8F golgin A8 family, member F 2.29063
NALF1 NALCN channel auxiliary factor 1 2.28679
MAN1C1 mannosidase, alpha, class 1C, member 1 2.2851
ECHDC2 enoyl CoA hydratase domain containing 2 2.28395
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 2.27901
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 2.27337
GATA3 GATA binding protein 3 2.27279
RNASE6 ribonuclease, RNase A family, k6 2.27109
DUSP6 dual specificity phosphatase 6 2.26892
CFDP1 craniofacial development protein 1 2.26698
DNASE1L3 deoxyribonuclease I-like 3 2.26196
DNAH7 dynein, axonemal, heavy chain 7 2.25208
LARS1 leucyl-tRNA synthetase 1 2.24753
CSAD cysteine sulfinic acid decarboxylase 2.24634
TRIM22 tripartite motif containing 22 2.2449
OR52A1 olfactory receptor, family 52, subfamily A, member 1 2.24326
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 2.24063
EPB41L5 erythrocyte membrane protein band 4.1 like 5 2.24027
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.23681
ACKR5 atypical chemokine receptor 5 2.23466
LGALS9C lectin, galactoside-binding, soluble, 9C 2.23201
SECISBP2 SECIS binding protein 2 2.22917
RIMBP2 RIMS binding protein 2 2.2251
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 2.22107
ZNF516 zinc finger protein 516 2.21654
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 2.21476
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.209
GNA14 guanine nucleotide binding protein (G protein), alpha 14 2.2086
IFT81 intraflagellar transport 81 2.20687
MXD3 MAX dimerization protein 3 2.20578
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 2.20052
TMPRSS5 transmembrane protease, serine 5 2.19714
SP4 Sp4 transcription factor 2.19524
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene) 2.19088
FKTN fukutin 2.18664
ZNF10 zinc finger protein 10 2.18378
SLC44A1 solute carrier family 44 (choline transporter), member 1 2.18305
PLCB2 phospholipase C, beta 2 2.17996
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.17766
UTRN utrophin 2.17715
RPH3A rabphilin 3A 2.17103
PDE3A phosphodiesterase 3A, cGMP-inhibited 2.17054
LONP2 lon peptidase 2, peroxisomal 2.16743
PGR progesterone receptor 2.16528
ULK2 unc-51 like autophagy activating kinase 2 2.16317
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.16179
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.16105
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.16067
CXCR4 chemokine (C-X-C motif) receptor 4 2.15495
MANSC1 MANSC domain containing 1 2.15373
ACSBG1 acyl-CoA synthetase bubblegum family member 1 2.15328
ENTREP1 endosomal transmembrane epsin interactor 1 2.15179
ZNF480 zinc finger protein 480 2.1472
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 2.14672
ZNF23 zinc finger protein 23 2.14635
HHEX hematopoietically expressed homeobox 2.14486
ADAM28 ADAM metallopeptidase domain 28 2.14398
HLA-DOB major histocompatibility complex, class II, DO beta 2.14247
FEV FEV (ETS oncogene family) 2.14042
ZNF134 zinc finger protein 134 2.14041
PELI2 pellino E3 ubiquitin protein ligase family member 2 2.13987
ADRB3 adrenoceptor beta 3 2.13814
DPF3 D4, zinc and double PHD fingers, family 3 2.13341
IGSF1 immunoglobulin superfamily, member 1 2.12846
RBM12 RNA binding motif protein 12 2.12009
FAM20B family with sequence similarity 20, member B 2.11957
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 2.11634
CD83 CD83 molecule 2.11249
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 2.11182
NME8 NME/NM23 family member 8 2.11147
VAV3 vav 3 guanine nucleotide exchange factor 2.11078
EP400 E1A binding protein p400 2.10815
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 2.10688
SIRPG signal-regulatory protein gamma 2.10605
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 2.0983
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.08938
ABHD6 abhydrolase domain containing 6 2.08741
TAOK3 TAO kinase 3 2.08557
MLPH melanophilin 2.08347
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.08316
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 2.07864
LOC122526780 uncharacterized LOC122526780 2.07805
ERCC4 excision repair cross-complementation group 4 2.0773
ZBTB44 zinc finger and BTB domain containing 44 2.07462
PAQR6 progestin and adipoQ receptor family member VI 2.07206
CA14 carbonic anhydrase XIV 2.07106
ZNF548 zinc finger protein 548 2.07098
CALML4 calmodulin-like 4 2.06918
PLA2G2D phospholipase A2, group IID 2.06865
GGT5 gamma-glutamyltransferase 5 2.0682
CCDC68 coiled-coil domain containing 68 2.06717
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 2.06408
SIRPB1 signal-regulatory protein beta 1 2.06326
GDF3 growth differentiation factor 3 2.05847
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.05825
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.05446
GSTM5 glutathione S-transferase mu 5 2.05238
FBXO46 F-box protein 46 2.05208
CEP83 centrosomal protein 83kDa 2.05089
HLA-DMA major histocompatibility complex, class II, DM alpha 2.04937
LOC100996709 ADP-ribosylation factor-like protein 17 2.04903
TERT telomerase reverse transcriptase 2.0465
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.0463
PNPLA3 patatin-like phospholipase domain containing 3 2.04608
PPP1R12B protein phosphatase 1, regulatory subunit 12B 2.04495
SNAP91 synaptosomal-associated protein, 91kDa 2.04402
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.04232
TEX28 testis expressed 28 2.03766
NFASC neurofascin 2.03281
TEX13B testis expressed 13B 2.03102
CLDN8 claudin 8 2.02974
DCHS2 dachsous cadherin-related 2 2.02959
ELAVL2 ELAV like neuron-specific RNA binding protein 2 2.0285
CST1 cystatin SN 2.0242
GTF2A1 general transcription factor IIA, 1, 19/37kDa 2.02347
TRPS1 trichorhinophalangeal syndrome I 2.02323
LY86 lymphocyte antigen 86 2.02082
FN3KRP fructosamine 3 kinase related protein 2.02047
CHAD chondroadherin 2.01859
SIGLEC6 sialic acid binding Ig-like lectin 6 2.01443
IL21 interleukin 21 2.01337
MTUS2 microtubule associated tumor suppressor candidate 2 2.01225
GOLGA8N golgin A8 family, member N 2.0116
STAT5B signal transducer and activator of transcription 5B 2.00749
CA5A carbonic anhydrase VA, mitochondrial 2.00569
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 2.0041
MITF microphthalmia-associated transcription factor 2.00213
ZIM3 zinc finger, imprinted 3 2.00188

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -5.57771
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.6443
CDC25B cell division cycle 25B -4.54951
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -4.32371
HMG20B high mobility group 20B -4.20097
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -4.03171
STXBP2 syntaxin binding protein 2 -3.82704
KRT14 keratin 14, type I -3.6139
HAX1 HCLS1 associated protein X-1 -3.60801
IPO13 importin 13 -3.3735
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 -3.3453
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide -3.29754
RPS5 ribosomal protein S5 -3.25938
DCAF6 DDB1 and CUL4 associated factor 6 -3.24264
ADI1 acireductone dioxygenase 1 -3.02506
PCCB propionyl CoA carboxylase, beta polypeptide -3.00127
MT1X metallothionein 1X -2.9472
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.89727
HTRA2 HtrA serine peptidase 2 -2.89626
IFRD2 interferon-related developmental regulator 2 -2.87645
MT2A metallothionein 2A -2.79327
TMEM115 transmembrane protein 115 -2.77834
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.76746
PPIE peptidylprolyl isomerase E (cyclophilin E) -2.6274
APEH acylaminoacyl-peptide hydrolase -2.56348
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) -2.54214
RTL10 retrotransposon Gag like 10 -2.52599
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.51877
MTFR1 mitochondrial fission regulator 1 -2.50458
GIN1 gypsy retrotransposon integrase 1 -2.48758
BLCAP bladder cancer associated protein -2.47054
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -2.42745
TMEM187 transmembrane protein 187 -2.42326
MRPL49 mitochondrial ribosomal protein L49 -2.41813
NELFE negative elongation factor complex member E -2.41604
ZMAT5 zinc finger, matrin-type 5 -2.39716
CLDN1 claudin 1 -2.38675
SAR1B secretion associated, Ras related GTPase 1B -2.38592
MTERF3 mitochondrial transcription termination factor 3 -2.38552
ARL2 ADP-ribosylation factor-like 2 -2.37647
BCL7B B-cell CLL/lymphoma 7B -2.35616
HIGD1A HIG1 hypoxia inducible domain family, member 1A -2.34502
BOLA1 bolA family member 1 -2.34006
TUSC2 tumor suppressor candidate 2 -2.33595
SNX6 sorting nexin 6 -2.31205
AVPI1 arginine vasopressin-induced 1 -2.30512
MRPS18B mitochondrial ribosomal protein S18B -2.28899
FASTK Fas-activated serine/threonine kinase -2.28065
DYNLT1 dynein, light chain, Tctex-type 1 -2.27938
RIN1 Ras and Rab interactor 1 -2.27688
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) -2.27392
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.27261
INTS12 integrator complex subunit 12 -2.27224
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) -2.26998
UQCRC1 ubiquinol-cytochrome c reductase core protein I -2.2629
GBA1 glucosylceramidase beta 1 -2.24376
AUP1 ancient ubiquitous protein 1 -2.22037
DEXI Dexi homolog (mouse) -2.21542
BZW2 basic leucine zipper and W2 domains 2 -2.21224
ZNF410 zinc finger protein 410 -2.21155
SFMBT1 Scm-like with four mbt domains 1 -2.19787
ERI3 ERI1 exoribonuclease family member 3 -2.18631
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta -2.17648
GALE UDP-galactose-4-epimerase -2.17511
STAMBP STAM binding protein -2.17027
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.16474
TCF15 transcription factor 15 (basic helix-loop-helix) -2.1625
CAPN1 calpain 1, (mu/I) large subunit -2.15657
FASTKD3 FAST kinase domains 3 -2.15547
LOC124908558 X antigen family member 1-like -2.13833
WASF1 WAS protein family, member 1 -2.13524
INTS3 integrator complex subunit 3 -2.12951
KLF5 Kruppel-like factor 5 (intestinal) -2.12854
JTB jumping translocation breakpoint -2.12248
OXSM 3-oxoacyl-ACP synthase, mitochondrial -2.11136
STN1 STN1 subunit of CST complex -2.10256
CYREN cell cycle regulator of NHEJ -2.09205
CYBRD1 cytochrome b reductase 1 -2.09173
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -2.08539
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.08299
MUS81 MUS81 structure-specific endonuclease subunit -2.07804
NEK7 NIMA-related kinase 7 -2.07786
MRPL24 mitochondrial ribosomal protein L24 -2.07157
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.05007
ACKR1 atypical chemokine receptor 1 (Duffy blood group) -2.04998
TPRA1 transmembrane protein, adipocyte asscociated 1 -2.04876
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.04815
MST1R macrophage stimulating 1 receptor -2.04787
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -2.04579
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -2.04113
MRPL37 mitochondrial ribosomal protein L37 -2.03904
RPA3 replication protein A3, 14kDa -2.03547
C2CD2 C2 calcium-dependent domain containing 2 -2.0305
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -2.03017
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.02613
PEX10 peroxisomal biogenesis factor 10 -2.01943
EDC3 enhancer of mRNA decapping 3 -2.01934
FOLR3 folate receptor 3 (gamma) -2.00286
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) -2.00011