CRCGN016_MCF10A.TP53.M_24H:O02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

88 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:O02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.5387
SSBP2 single-stranded DNA binding protein 2 4.62386
KDM5D lysine (K)-specific demethylase 5D 3.86081
CXCR4 chemokine (C-X-C motif) receptor 4 3.6787
HBA1 hemoglobin, alpha 1 3.38502
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.81853
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 2.74254
CRY1 cryptochrome circadian clock 1 2.71678
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.66163
AGO2 argonaute RISC catalytic component 2 2.56001
MAST2 microtubule associated serine/threonine kinase 2 2.49413
PDLIM1 PDZ and LIM domain 1 2.48408
TMEM267 transmembrane protein 267 2.39443
SUB1 SUB1 homolog (S. cerevisiae) 2.36917
HSPA13 heat shock protein 70kDa family, member 13 2.34395
TMED7 transmembrane emp24 protein transport domain containing 7 2.30591
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 2.28437
TLCD3A TLC domain containing 3A 2.27021
C1QA complement component 1, q subcomponent, A chain 2.26694
PFDN1 prefoldin subunit 1 2.24494
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.24061
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) 2.2138
BCAP29 B-cell receptor-associated protein 29 2.18497
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 2.17377
VTA1 vesicle (multivesicular body) trafficking 1 2.16186
MED21 mediator complex subunit 21 2.15387
CGRRF1 cell growth regulator with ring finger domain 1 2.11564
ENOPH1 enolase-phosphatase 1 2.10147
RIOK2 RIO kinase 2 2.1002
TBPL1 TBP-like 1 2.09863
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.0985
GABPA GA binding protein transcription factor, alpha subunit 60kDa 2.09177
RBM7 RNA binding motif protein 7 2.05706
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 2.04506
ANAPC10 anaphase promoting complex subunit 10 2.03837
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2.03829
TASOR2 transcription activation suppressor family member 2 2.03035
BRIX1 BRX1, biogenesis of ribosomes 2.00783

decreased expression

Symbol Name Standardized Value
TIMP1 TIMP metallopeptidase inhibitor 1 -4.95771
MRPS2 mitochondrial ribosomal protein S2 -4.66241
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.37116
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.20903
SCYL3 SCY1-like 3 (S. cerevisiae) -4.19224
CAB39 calcium binding protein 39 -4.0916
MAPK13 mitogen-activated protein kinase 13 -3.98753
UBE3C ubiquitin protein ligase E3C -3.67278
PPP1R26 protein phosphatase 1, regulatory subunit 26 -3.30486
CAPN2 calpain 2, (m/II) large subunit -2.96917
OAT ornithine aminotransferase -2.9165
COQ4 coenzyme Q4 -2.87175
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.84007
PFN1 profilin 1 -2.81231
UBA1 ubiquitin-like modifier activating enzyme 1 -2.79342
SMC1A structural maintenance of chromosomes 1A -2.78779
BMP8B bone morphogenetic protein 8b -2.77735
CTNND1 catenin (cadherin-associated protein), delta 1 -2.69069
KDM5C lysine (K)-specific demethylase 5C -2.67301
PAEP progestagen-associated endometrial protein -2.67173
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa -2.58669
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.57317
TRIB3 tribbles pseudokinase 3 -2.48855
VDAC1 voltage-dependent anion channel 1 -2.41059
PIGB phosphatidylinositol glycan anchor biosynthesis, class B -2.40933
PUDP pseudouridine 5'-phosphatase -2.33854
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) -2.33101
KIFAP3 kinesin-associated protein 3 -2.33036
RCC1L RCC1 like -2.29693
IPO13 importin 13 -2.28024
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.27859
ETFA electron-transfer-flavoprotein, alpha polypeptide -2.27305
SEC16A SEC16 homolog A (S. cerevisiae) -2.26741
OTOR otoraplin -2.23454
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -2.22333
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor -2.21047
RNPEP arginyl aminopeptidase (aminopeptidase B) -2.18894
NELFB negative elongation factor complex member B -2.18061
NUAK2 NUAK family, SNF1-like kinase, 2 -2.16794
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 -2.13282
OVOL2 ovo-like zinc finger 2 -2.12886
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) -2.11622
PMPCA peptidase (mitochondrial processing) alpha -2.11044
CALML5 calmodulin-like 5 -2.10426
USP9X ubiquitin specific peptidase 9, X-linked -2.09336
MVP major vault protein -2.08825
ZNF419 zinc finger protein 419 -2.07217
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa -2.0549
WNT5B wingless-type MMTV integration site family, member 5B -2.02925
HMBOX1 homeobox containing 1 -2.02249