CRCGN016_MCF10A.TP53.M_24H:O03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:O03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.8877
H2BC21 H2B clustered histone 21 4.8217
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.80009
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.7223
SPAG4 sperm associated antigen 4 4.66275
KLHL21 kelch-like family member 21 4.65435
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.63725
MICALL1 MICAL-like 1 3.81233
LYN LYN proto-oncogene, Src family tyrosine kinase 3.03547
TOMM34 translocase of outer mitochondrial membrane 34 2.82815
SIRT3 sirtuin 3 2.68402
ADRB2 adrenoceptor beta 2, surface 2.6786
CCNA1 cyclin A1 2.50555
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.48215
CGRRF1 cell growth regulator with ring finger domain 1 2.40535
MXRA7 matrix-remodelling associated 7 2.3156
ARHGAP19 Rho GTPase activating protein 19 2.29427
ECI2 enoyl-CoA delta isomerase 2 2.28885
FMNL1 formin-like 1 2.23545
HSPA8 heat shock 70kDa protein 8 2.20132
UTP11 UTP11 small subunit processome component 2.1976
SCG5 secretogranin V 2.18685
KRT10 keratin 10, type I 2.1238
NPC2 Niemann-Pick disease, type C2 2.11825
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.08755
TRAPPC2L trafficking protein particle complex 2-like 2.08605
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2.0848
NPM3 nucleophosmin/nucleoplasmin 3 2.07285
MAP7D1 MAP7 domain containing 1 2.0528
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 2.05095
RBBP8 retinoblastoma binding protein 8 2.043
GNG7 guanine nucleotide binding protein (G protein), gamma 7 2.0197

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.3777
S100A8 S100 calcium binding protein A8 -5.22395
SLC35B1 solute carrier family 35, member B1 -4.7949
CCNB1 cyclin B1 -4.70615
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.70295
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.41248
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.51152
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.315
TLK2 tousled-like kinase 2 -3.14722
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -2.9352
BCAP31 B-cell receptor-associated protein 31 -2.83385
MPO myeloperoxidase -2.75242
CGREF1 cell growth regulator with EF-hand domain 1 -2.5794
GDI1 GDP dissociation inhibitor 1 -2.5641
ITGA9 integrin, alpha 9 -2.4451
TMEM214 transmembrane protein 214 -2.4148
SLC38A10 solute carrier family 38, member 10 -2.38955
CETN2 centrin, EF-hand protein, 2 -2.3705
ZNF660-ZNF197 ZNF660-ZNF197 readthrough -2.34215
VAMP7 vesicle-associated membrane protein 7 -2.33795
HYAL2 hyaluronoglucosaminidase 2 -2.33305
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -2.32705
ATXN2 ataxin 2 -2.2975
TEX2 testis expressed 2 -2.27065
CAPN2 calpain 2, (m/II) large subunit -2.24987
LRRC1 leucine rich repeat containing 1 -2.23795
MAB21L1 mab-21-like 1 (C. elegans) -2.2376
ILK integrin-linked kinase -2.2335
ZFP36 ZFP36 ring finger protein -2.23195
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide -2.2245
FGR FGR proto-oncogene, Src family tyrosine kinase -2.2031
CSF3 colony stimulating factor 3 (granulocyte) -2.1805
PHB1 prohibitin 1 -2.16423
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -2.15947
GTPBP2 GTP binding protein 2 -2.1022
PREB prolactin regulatory element binding -2.09505
SSTR5 somatostatin receptor 5 -2.087
ATAD2B ATPase family, AAA domain containing 2B -2.07555
LHX1 LIM homeobox 1 -2.0732
DNASE1L1 deoxyribonuclease I-like 1 -2.0542
GPR22 G protein-coupled receptor 22 -2.0501
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.0398
KLHDC2 kelch domain containing 2 -2.03045
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase -2.02437
SSTR2 somatostatin receptor 2 -2.02183
BFSP1 beaded filament structural protein 1, filensin -2.0095