CRCGN016_MCF10A.TP53.M_24H:O04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:O04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 5.26124
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.52842
STK10 serine/threonine kinase 10 3.64443
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 3.29098
COMP cartilage oligomeric matrix protein 2.75005
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.6659
CCDC59 coiled-coil domain containing 59 2.166
SATB1 SATB homeobox 1 2.13968
YEATS4 YEATS domain containing 4 2.12695
LINC02762 long intergenic non-protein coding RNA 2762 2.12303
ASTN2 astrotactin 2 2.10387
TBPL1 TBP-like 1 2.09496
COL16A1 collagen, type XVI, alpha 1 2.06495
SMNDC1 survival motor neuron domain containing 1 2.03179
CNRIP1 cannabinoid receptor interacting protein 1 2.02547
HNRNPM heterogeneous nuclear ribonucleoprotein M 2.02018
PINLYP phospholipase A2 inhibitor and LY6/PLAUR domain containing 2.01848

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -9.00596
HMG20B high mobility group 20B -4.7574
PCCB propionyl CoA carboxylase, beta polypeptide -4.14754
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.92071
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.82749
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.80183
BASP1 brain abundant, membrane attached signal protein 1 -3.49647
MT1X metallothionein 1X -3.02911
GRN granulin -2.78102
PIH1D1 PIH1 domain containing 1 -2.71322
PROSER1 proline and serine rich 1 -2.43982
MRPS31 mitochondrial ribosomal protein S31 -2.4365
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.36078
S100A8 S100 calcium binding protein A8 -2.35171
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -2.30959
WBP4 WW domain binding protein 4 -2.13477
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.12928
SP140 SP140 nuclear body protein -2.12266
TKT transketolase -2.11068
BDNF brain-derived neurotrophic factor -2.08939
DCAF6 DDB1 and CUL4 associated factor 6 -2.08472
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) -2.0745
TUBA4A tubulin, alpha 4a -2.03574
ZNF672 zinc finger protein 672 -2.03191
CNN2 calponin 2 -2.02075
MTRF1 mitochondrial translational release factor 1 -2.00265