CRCGN016_MCF10A.TP53.M_24H:O08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K61463582 32.82 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

161 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:O08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MEF2C myocyte enhancer factor 2C 5.76542
ABHD4 abhydrolase domain containing 4 5.0311
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 4.83555
SNAP25 synaptosomal-associated protein, 25kDa 4.81285
FOS FBJ murine osteosarcoma viral oncogene homolog 4.752
GPER1 G protein-coupled estrogen receptor 1 3.87313
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.81118
GARRE1 granule associated Rac and RHOG effector 1 3.47885
FAM184A family with sequence similarity 184, member A 3.30455
SYN1 synapsin I 3.2214
EPN2 epsin 2 3.19685
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 3.1444
SNCA synuclein, alpha (non A4 component of amyloid precursor) 3.0502
LGMN legumain 2.99825
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 2.8381
SNAP91 synaptosomal-associated protein, 91kDa 2.7543
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.6409
MAP2K1 mitogen-activated protein kinase kinase 1 2.6235
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 2.5999
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.58485
RGS7 regulator of G-protein signaling 7 2.5717
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.5477
DENND2D DENN/MADD domain containing 2D 2.5466
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 2.48975
BCAP29 B-cell receptor-associated protein 29 2.4711
GTPBP8 GTP-binding protein 8 (putative) 2.4672
EHD3 EH-domain containing 3 2.4197
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 2.4119
DCPH1 damage control phosphatase 1 2.40025
EXOSC4 exosome component 4 2.39838
LMO3 LIM domain only 3 (rhombotin-like 2) 2.3953
NEFM neurofilament, medium polypeptide 2.3919
EMP2 epithelial membrane protein 2 2.3916
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 2.37295
ACAA1 acetyl-CoA acyltransferase 1 2.36655
ARHGAP1 Rho GTPase activating protein 1 2.35155
SNCB synuclein, beta 2.3493
GDF7 growth differentiation factor 7 2.31965
MGLL monoglyceride lipase 2.31555
SCN3B sodium channel, voltage gated, type III beta subunit 2.3115
VSNL1 visinin-like 1 2.31043
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.28685
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 2.2623
CLDN10 claudin 10 2.23755
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.23282
LPL lipoprotein lipase 2.22633
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 2.22131
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.2185
BAX BCL2-associated X protein 2.2051
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 2.19045
SWAP70 SWAP switching B-cell complex 70kDa subunit 2.18895
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.1871
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.17771
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.17485
RHOBTB2 Rho-related BTB domain containing 2 2.1689
FZD4 frizzled class receptor 4 2.16705
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.15915
AGPS alkylglycerone phosphate synthase 2.15735
LRP2 low density lipoprotein receptor-related protein 2 2.1499
ECM1 extracellular matrix protein 1 2.1294
TPGS1 tubulin polyglutamylase complex subunit 1 2.12805
CPM carboxypeptidase M 2.1005
BMP6 bone morphogenetic protein 6 2.10005
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.09195
TRAPPC2L trafficking protein particle complex 2-like 2.0872
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.08335
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 2.0828
SLC66A2 solute carrier family 66 member 2 2.082
SYT1 synaptotagmin I 2.07433
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 2.07075
ZNF747 zinc finger protein 747 2.0588
UNC13A unc-13 homolog A (C. elegans) 2.0531
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 2.04545
ARHGAP24 Rho GTPase activating protein 24 2.0421
CDK17 cyclin-dependent kinase 17 2.03825
APOE apolipoprotein E 2.02797
CYB5A cytochrome b5 type A (microsomal) 2.02145
DDN dendrin 2.01715
ATAD2B ATPase family, AAA domain containing 2B 2.01135
NSG2 neuronal vesicle trafficking associated 2 2.0099
RAB8B RAB8B, member RAS oncogene family 2.00635
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.00435
APRT adenine phosphoribosyltransferase 2.00045

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -10.0
KIF14 kinesin family member 14 -5.4799
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.11535
TRAPPC3 trafficking protein particle complex 3 -4.85168
HSPA8 heat shock 70kDa protein 8 -4.8302
TIMP1 TIMP metallopeptidase inhibitor 1 -4.62905
CDK4 cyclin-dependent kinase 4 -4.08055
GRN granulin -3.60087
ANXA2 annexin A2 -3.54602
PIH1D1 PIH1 domain containing 1 -3.3006
ERBIN erbb2 interacting protein -3.2027
TBCA tubulin folding cofactor A -3.08215
PCCB propionyl CoA carboxylase, beta polypeptide -2.9828
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.96475
MNX1 motor neuron and pancreas homeobox 1 -2.92895
HAX1 HCLS1 associated protein X-1 -2.8938
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.8858
MRPS15 mitochondrial ribosomal protein S15 -2.78795
KPTN kaptin (actin binding protein) -2.7289
HINT1 histidine triad nucleotide binding protein 1 -2.71177
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.69593
PFN2 profilin 2 -2.6731
DROSHA drosha, ribonuclease type III -2.63225
RAD17 RAD17 homolog (S. pombe) -2.54973
MRPS17 mitochondrial ribosomal protein S17 -2.53695
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -2.5269
FOXO4 forkhead box O4 -2.5199
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.51305
GTF2IRD1 GTF2I repeat domain containing 1 -2.46495
NBPF3 neuroblastoma breakpoint family, member 3 -2.4551
PLA1A phospholipase A1 member A -2.42015
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.41705
AURKA aurora kinase A -2.40908
CKS1B CDC28 protein kinase regulatory subunit 1B -2.3796
AOAH acyloxyacyl hydrolase (neutrophil) -2.37105
SERF1A small EDRK-rich factor 1A (telomeric) -2.37025
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.3643
RACGAP1 Rac GTPase activating protein 1 -2.3067
JADE2 jade family PHD finger 2 -2.27733
TRIB3 tribbles pseudokinase 3 -2.2705
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -2.26695
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.2638
SETD1A SET domain containing 1A -2.2465
RPS5 ribosomal protein S5 -2.2278
DHPS deoxyhypusine synthase -2.22068
ARB2A ARB2 cotranscriptional regulator A -2.19775
MNDA myeloid cell nuclear differentiation antigen -2.1866
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -2.17805
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -2.1764
SMG8 SMG8 nonsense mediated mRNA decay factor -2.1682
MEAF6 MYST/Esa1-associated factor 6 -2.16355
R3HDM2 R3H domain containing 2 -2.1593
CBX3 chromobox homolog 3 -2.15893
INTS8 integrator complex subunit 8 -2.1579
PHB2 prohibitin 2 -2.1532
MTERF3 mitochondrial transcription termination factor 3 -2.1499
MRPL9 mitochondrial ribosomal protein L9 -2.14022
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -2.13805
COPZ1 coatomer protein complex, subunit zeta 1 -2.1364
ECT2 epithelial cell transforming 2 -2.11115
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -2.11005
BTN3A3 butyrophilin, subfamily 3, member A3 -2.1055
TRIM58 tripartite motif containing 58 -2.10405
EIF3L eukaryotic translation initiation factor 3, subunit L -2.0988
FTL ferritin, light polypeptide -2.09825
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa -2.0931
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.0882
AURKB aurora kinase B -2.0851
ZFYVE26 zinc finger, FYVE domain containing 26 -2.07775
BLCAP bladder cancer associated protein -2.06855
CBX1 chromobox homolog 1 -2.0539
BCAS3 breast carcinoma amplified sequence 3 -2.046
BORA bora, aurora kinase A activator -2.04305
HDAC3 histone deacetylase 3 -2.04205
CCN3 cellular communication network factor 3 -2.0258
C1GALT1C1 C1GALT1-specific chaperone 1 -2.0173
GAA glucosidase, alpha; acid -2.0065
TAC4 tachykinin 4 (hemokinin) -2.00115