CRCGN016_MCF10A.TP53.M_24H:O12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description estrone 11.35 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:O12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 4.7881
RAB21 RAB21, member RAS oncogene family 3.54801
HLA-DRA major histocompatibility complex, class II, DR alpha 2.93007
PLS1 plastin 1 2.88253
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.83456
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.74243
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.59132
SMNDC1 survival motor neuron domain containing 1 2.34261
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.33604
CADM1 cell adhesion molecule 1 2.22661
CGRRF1 cell growth regulator with ring finger domain 1 2.18838
LYRM1 LYR motif containing 1 2.17875
RBM15B RNA binding motif protein 15B 2.17779
CETN3 centrin, EF-hand protein, 3 2.1344
CHN1 chimerin 1 2.11306
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 2.06625
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.02659
CHODL chondrolectin 2.00026

decreased expression

Symbol Name Standardized Value
NT5DC2 5'-nucleotidase domain containing 2 -5.30615
HMG20B high mobility group 20B -4.7
KRT14 keratin 14, type I -4.38204
VDAC1 voltage-dependent anion channel 1 -4.14375
C2CD5 C2 calcium-dependent domain containing 5 -4.01753
PCNA proliferating cell nuclear antigen -3.71202
SGK1 serum/glucocorticoid regulated kinase 1 -3.5949
BLCAP bladder cancer associated protein -3.43613
MT1X metallothionein 1X -2.90055
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.84005
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -2.58023
MVP major vault protein -2.48521
MTERF3 mitochondrial transcription termination factor 3 -2.47026
NSFL1C NSFL1 (p97) cofactor (p47) -2.44161
TKT transketolase -2.41571
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.40319
DDRGK1 DDRGK domain containing 1 -2.35569
TNIP1 TNFAIP3 interacting protein 1 -2.30331
ANXA2 annexin A2 -2.22209
ETFB electron-transfer-flavoprotein, beta polypeptide -2.20779
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.14514
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.12857
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.11659
TM9SF3 transmembrane 9 superfamily member 3 -2.11008
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -2.09097
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.07116
PANK2 pantothenate kinase 2 -2.06972
PYGB phosphorylase, glycogen; brain -2.04304
LRP10 low density lipoprotein receptor-related protein 10 -2.0274
STK25 serine/threonine kinase 25 -2.00046