CRCGN016_MCF10A.TP53.M_24H:O16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyanazine 98.4 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

307 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:O16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
COMP cartilage oligomeric matrix protein 3.92398
LGMN legumain 3.79794
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.43667
LYN LYN proto-oncogene, Src family tyrosine kinase 3.35289
PCNA proliferating cell nuclear antigen 3.20307
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.19435
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 3.10335
STXBP3 syntaxin binding protein 3 2.97356
AGR2 anterior gradient 2 2.94451
ISOC1 isochorismatase domain containing 1 2.92663
TOMM34 translocase of outer mitochondrial membrane 34 2.87498
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.84334
SNX11 sorting nexin 11 2.82944
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 2.79672
ISLR immunoglobulin superfamily containing leucine-rich repeat 2.78084
MXRA8 matrix-remodelling associated 8 2.71068
PLS1 plastin 1 2.64928
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2.64844
GARRE1 granule associated Rac and RHOG effector 1 2.62808
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 2.62426
CHST10 carbohydrate sulfotransferase 10 2.59553
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.57024
HOXA5 homeobox A5 2.56673
PARM1 prostate androgen-regulated mucin-like protein 1 2.5666
TPO thyroid peroxidase 2.56151
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.53973
PLAT plasminogen activator, tissue 2.51233
AP3M2 adaptor-related protein complex 3, mu 2 subunit 2.50105
RGS4 regulator of G-protein signaling 4 2.50055
PDGFRL platelet-derived growth factor receptor-like 2.47574
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 2.4746
NUP153 nucleoporin 153kDa 2.47394
C5 complement component 5 2.44607
CNTNAP1 contactin associated protein 1 2.42612
FUBP3 far upstream element (FUSE) binding protein 3 2.42389
RNF144A ring finger protein 144A 2.41607
ADORA2B adenosine A2b receptor 2.41369
IL1B interleukin 1, beta 2.40954
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 2.40375
BCL10 B-cell CLL/lymphoma 10 2.40299
ENOPH1 enolase-phosphatase 1 2.39865
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.38581
CTSK cathepsin K 2.38358
LXN latexin 2.37037
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.36169
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.34719
IGSF1 immunoglobulin superfamily, member 1 2.33939
MORC3 MORC family CW-type zinc finger 3 2.33411
THSD7A thrombospondin, type I, domain containing 7A 2.32976
NAV3 neuron navigator 3 2.31665
PRDM4 PR domain containing 4 2.31631
ADAT1 adenosine deaminase, tRNA-specific 1 2.31352
FOS FBJ murine osteosarcoma viral oncogene homolog 2.31062
DUSP4 dual specificity phosphatase 4 2.3094
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.30721
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2.2899
GATA3 GATA binding protein 3 2.28298
SH2B3 SH2B adaptor protein 3 2.27084
APOE apolipoprotein E 2.26397
SRPK1 SRSF protein kinase 1 2.2544
FAM3C family with sequence similarity 3, member C 2.25429
CCL23 chemokine (C-C motif) ligand 23 2.25327
RPIA ribose 5-phosphate isomerase A 2.25288
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 2.25119
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.24778
PSD3 pleckstrin and Sec7 domain containing 3 2.24577
MCFD2 multiple coagulation factor deficiency 2 2.23804
UFM1 ubiquitin-fold modifier 1 2.23117
DPYD dihydropyrimidine dehydrogenase 2.22603
RLF rearranged L-myc fusion 2.2256
CRY1 cryptochrome circadian clock 1 2.22428
RIOX1 ribosomal oxygenase 1 2.22412
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.22055
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 2.21693
RGS2 regulator of G-protein signaling 2 2.21691
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 2.20948
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.20748
ZNHIT6 zinc finger, HIT-type containing 6 2.1999
FAM124B family with sequence similarity 124B 2.19781
CDKN2AIP CDKN2A interacting protein 2.19069
SFRP4 secreted frizzled-related protein 4 2.18319
NR3C2 nuclear receptor subfamily 3, group C, member 2 2.17993
PAQR3 progestin and adipoQ receptor family member III 2.1774
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 2.15692
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.15666
SOCS6 suppressor of cytokine signaling 6 2.15581
NALF1 NALCN channel auxiliary factor 1 2.15566
KLF10 Kruppel-like factor 10 2.15466
AMT aminomethyltransferase 2.15301
CA7 carbonic anhydrase VII 2.15281
SYTL2 synaptotagmin-like 2 2.1454
VLDLR very low density lipoprotein receptor 2.14505
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.13906
CYRIA CYFIP related Rac1 interactor A 2.12194
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 2.11021
CEP170 centrosomal protein 170kDa 2.10959
EYA3 EYA transcriptional coactivator and phosphatase 3 2.10912
EIF4E eukaryotic translation initiation factor 4E 2.10879
FCGBP Fc fragment of IgG binding protein 2.09354
TERT telomerase reverse transcriptase 2.0902
GDAP2 ganglioside induced differentiation associated protein 2 2.08926
MPPED2 metallophosphoesterase domain containing 2 2.08866
CGRRF1 cell growth regulator with ring finger domain 1 2.08744
AQP8 aquaporin 8 2.08229
WDR47 WD repeat domain 47 2.08195
STAT5A signal transducer and activator of transcription 5A 2.07052
TOPBP1 topoisomerase (DNA) II binding protein 1 2.06867
TAGLN3 transgelin 3 2.06189
NID2 nidogen 2 (osteonidogen) 2.06013
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.05955
EPCIP exosomal polycystin 1 interacting protein 2.0593
SLC35G2 solute carrier family 35, member G2 2.05675
RNF38 ring finger protein 38 2.05626
ACSL4 acyl-CoA synthetase long-chain family member 4 2.05587
TCP10L t-complex 10-like 2.05463
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.05242
KLHL29 kelch-like family member 29 2.05196
EVI5 ecotropic viral integration site 5 2.05002
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough 2.03497
CD207 CD207 molecule, langerin 2.03471
EFR3B EFR3 homolog B (S. cerevisiae) 2.02532
SOCS5 suppressor of cytokine signaling 5 2.02442
CPQ carboxypeptidase Q 2.02155
NUP54 nucleoporin 54kDa 2.01724
HMGA2 high mobility group AT-hook 2 2.0112
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.00902
OR52A1 olfactory receptor, family 52, subfamily A, member 1 2.00188

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -8.22865
TUBA4A tubulin, alpha 4a -6.31921
HMG20B high mobility group 20B -5.7318
SPAG7 sperm associated antigen 7 -4.92154
MSMO1 methylsterol monooxygenase 1 -4.5273
NUSAP1 nucleolar and spindle associated protein 1 -4.40064
AARS1 alanyl-tRNA synthetase 1 -4.04432
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.78047
ETFB electron-transfer-flavoprotein, beta polypeptide -3.70444
SH3D19 SH3 domain containing 19 -3.66083
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -3.64801
NLRP4 NLR family, pyrin domain containing 4 -3.64257
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.49569
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -3.49171
INTS3 integrator complex subunit 3 -3.40696
TECR trans-2,3-enoyl-CoA reductase -3.26963
TWF2 twinfilin actin binding protein 2 -3.26962
ECH1 enoyl CoA hydratase 1, peroxisomal -3.26737
GALE UDP-galactose-4-epimerase -3.24773
UQCRC1 ubiquinol-cytochrome c reductase core protein I -3.15051
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -3.077
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.0225
DDIT4 DNA-damage-inducible transcript 4 -3.01133
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.99162
MRPS16 mitochondrial ribosomal protein S16 -2.98719
TKT transketolase -2.95091
AP2M1 adaptor-related protein complex 2, mu 1 subunit -2.94807
PMVK phosphomevalonate kinase -2.94598
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) -2.94233
DNM2 dynamin 2 -2.91331
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -2.89982
BAD BCL2-associated agonist of cell death -2.88793
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -2.86226
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha -2.85773
HSPB1 heat shock 27kDa protein 1 -2.83712
GOLT1B golgi transport 1B -2.83279
CSK c-src tyrosine kinase -2.82133
BRMS1L breast cancer metastasis-suppressor 1-like -2.80197
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -2.78633
NCAPD2 non-SMC condensin I complex, subunit D2 -2.76479
TSC22D3 TSC22 domain family, member 3 -2.76297
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.75725
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 -2.74648
SERF2 small EDRK-rich factor 2 -2.73547
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.73377
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.71976
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -2.71137
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.71012
MRPL12 mitochondrial ribosomal protein L12 -2.70938
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 -2.7032
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.6887
TACC3 transforming, acidic coiled-coil containing protein 3 -2.6732
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.67295
TSPAN4 tetraspanin 4 -2.67065
DDB2 damage-specific DNA binding protein 2, 48kDa -2.66798
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.65321
ECSIT ECSIT signalling integrator -2.64972
INPPL1 inositol polyphosphate phosphatase-like 1 -2.62594
TMED1 transmembrane emp24 protein transport domain containing 1 -2.62498
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -2.62418
HACL2 2-hydroxyacyl-CoA lyase 2 -2.61736
FPGS folylpolyglutamate synthase -2.61667
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.61092
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.60696
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.60427
MRPL30 mitochondrial ribosomal protein L30 -2.59451
UBE2S ubiquitin-conjugating enzyme E2S -2.59134
MPDU1 mannose-P-dolichol utilization defect 1 -2.58565
GFUS GDP-L-fucose synthase -2.5717
DHCR7 7-dehydrocholesterol reductase -2.54621
TLE5 TLE family member 5, transcriptional modulator -2.54086
RNF187 ring finger protein 187 -2.53934
ANXA2 annexin A2 -2.51928
CD81 CD81 molecule -2.51928
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.50524
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -2.49927
RPL3 ribosomal protein L3 -2.47441
MLF2 myeloid leukemia factor 2 -2.46995
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.45475
PFN1 profilin 1 -2.45046
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.44382
TMEM134 transmembrane protein 134 -2.43068
GUK1 guanylate kinase 1 -2.4293
ARF5 ADP-ribosylation factor 5 -2.42777
TOP6BL TOP6B like initiator of meiotic double strand breaks -2.42627
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.42339
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.40149
MVD mevalonate (diphospho) decarboxylase -2.40098
LGALS7B lectin, galactoside-binding, soluble, 7B -2.38959
PEX10 peroxisomal biogenesis factor 10 -2.38638
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.37843
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) -2.36043
PTOV1 prostate tumor overexpressed 1 -2.34574
AMDHD2 amidohydrolase domain containing 2 -2.34384
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -2.3435
PIEZO1 piezo-type mechanosensitive ion channel component 1 -2.33894
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.33396
PLK1 polo-like kinase 1 -2.33134
LOC112694756 uncharaterized LOC112694756 -2.3279
WDR83OS WD repeat domain 83 opposite strand -2.31973
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -2.31888
RFXANK regulatory factor X-associated ankyrin-containing protein -2.31385
NUCB1 nucleobindin 1 -2.31255
TMED9 transmembrane emp24 protein transport domain containing 9 -2.31054
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.30341
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.30143
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa -2.30077
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -2.29958
ADGRE5 adhesion G protein-coupled receptor E5 -2.29938
CD151 CD151 molecule (Raph blood group) -2.29825
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.29294
MAEA macrophage erythroblast attacher -2.28285
ZNF768 zinc finger protein 768 -2.26725
UBXN6 UBX domain protein 6 -2.26585
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.26415
GPX4 glutathione peroxidase 4 -2.26065
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.26056
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.2605
KAT5 K(lysine) acetyltransferase 5 -2.24377
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.2428
PINK1 PTEN induced putative kinase 1 -2.24023
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.23331
RPS5 ribosomal protein S5 -2.23134
FLNA filamin A, alpha -2.22809
SCARB1 scavenger receptor class B, member 1 -2.20805
RCOR3 REST corepressor 3 -2.20614
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -2.20251
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.18435
GPS1 G protein pathway suppressor 1 -2.15879
FOXM1 forkhead box M1 -2.15647
ISOC2 isochorismatase domain containing 2 -2.15262
COG4 component of oligomeric golgi complex 4 -2.15191
CDC37 cell division cycle 37 -2.14196
RPL18A ribosomal protein L18a -2.13861
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -2.13691
HAT1 histone acetyltransferase 1 -2.13467
GNPAT glyceronephosphate O-acyltransferase -2.13335
ATP5F1B ATP synthase F1 subunit beta -2.12997
STXBP2 syntaxin binding protein 2 -2.12514
YJU2B YJU2 splicing factor homolog B -2.11663
ATP5F1D ATP synthase F1 subunit delta -2.11561
MRPL37 mitochondrial ribosomal protein L37 -2.11212
PER1 period circadian clock 1 -2.11003
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -2.09545
PTMS parathymosin -2.09073
FBXW4 F-box and WD repeat domain containing 4 -2.08874
MCRS1 microspherule protein 1 -2.08826
RNF126 ring finger protein 126 -2.08585
CLN3 ceroid-lipofuscinosis, neuronal 3 -2.08331
BABAM1 BRISC and BRCA1 A complex member 1 -2.08121
PTGES2 prostaglandin E synthase 2 -2.08095
RPL11 ribosomal protein L11 -2.07779
CDCA3 cell division cycle associated 3 -2.07689
KIF2C kinesin family member 2C -2.07652
EMD emerin -2.07307
SREBF2 sterol regulatory element binding transcription factor 2 -2.06894
UROS uroporphyrinogen III synthase -2.0651
MUS81 MUS81 structure-specific endonuclease subunit -2.05667
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -2.05365
PYGL phosphorylase, glycogen, liver -2.05358
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.04636
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.03348
MECR mitochondrial trans-2-enoyl-CoA reductase -2.03242
PUF60 poly-U binding splicing factor 60KDa -2.03192
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) -2.03007
GATD3 glutamine amidotransferase class 1 domain containing 3 -2.0264
RNF220 ring finger protein 220 -2.02424
GET3 guided entry of tail-anchored proteins factor 3, ATPase -2.02327
PILRB paired immunoglobin-like type 2 receptor beta -2.02268
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.01817
NQO2 NAD(P)H dehydrogenase, quinone 2 -2.01703
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B -2.01542
RANGAP1 Ran GTPase activating protein 1 -2.01432
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 -2.0138
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -2.01292
GMPPA GDP-mannose pyrophosphorylase A -2.0127
SREBF1 sterol regulatory element binding transcription factor 1 -2.01031
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) -2.00568
ARPC4-TTLL3 ARPC4-TTLL3 readthrough -2.00476
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -2.00145