CRCGN016_MCF10A.TP53.M_24H:O22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tolazamide 100.97 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

231 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:O22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
COMP cartilage oligomeric matrix protein 4.49315
FKBP14 FK506 binding protein 14, 22 kDa 4.05687
LYRM1 LYR motif containing 1 3.33834
BZW2 basic leucine zipper and W2 domains 2 3.24016
GET1 guided entry of tail-anchored proteins factor 1 3.20305
TBPL1 TBP-like 1 3.14951
COL11A1 collagen, type XI, alpha 1 3.02442
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 2.7938
ZNF586 zinc finger protein 586 2.77882
ISOC1 isochorismatase domain containing 1 2.68513
TDP2 tyrosyl-DNA phosphodiesterase 2 2.59235
CCNH cyclin H 2.58424
BTK Bruton agammaglobulinemia tyrosine kinase 2.58139
LIPT1 lipoyltransferase 1 2.57921
TFDP3 transcription factor Dp family, member 3 2.51971
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.50282
ZNF669 zinc finger protein 669 2.49134
THUMPD2 THUMP domain containing 2 2.47386
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.45961
EPCIP exosomal polycystin 1 interacting protein 2.45589
SETD6 SET domain containing 6 2.45244
SMNDC1 survival motor neuron domain containing 1 2.44897
RHOBTB1 Rho-related BTB domain containing 1 2.43556
FBXL2 F-box and leucine-rich repeat protein 2 2.39367
KLHL29 kelch-like family member 29 2.38149
ACTR8 ARP8 actin-related protein 8 homolog (yeast) 2.37792
GOLT1B golgi transport 1B 2.37605
LYRM9 LYR motif containing 9 2.36854
AP3M2 adaptor-related protein complex 3, mu 2 subunit 2.35134
BET1 Bet1 golgi vesicular membrane trafficking protein 2.35091
PAK1IP1 PAK1 interacting protein 1 2.34502
TRAPPC13 trafficking protein particle complex 13 2.33614
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 2.33352
TXNDC9 thioredoxin domain containing 9 2.32258
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2.31907
METTL2A methyltransferase like 2A 2.31245
CGRRF1 cell growth regulator with ring finger domain 1 2.30865
MYNN myoneurin 2.30061
AKAP5 A kinase (PRKA) anchor protein 5 2.29638
FLCN folliculin 2.29446
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 2.28862
GTPBP8 GTP-binding protein 8 (putative) 2.28509
TRIM13 tripartite motif containing 13 2.28349
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 2.28092
GPN1 GPN-loop GTPase 1 2.28067
MRPL44 mitochondrial ribosomal protein L44 2.26844
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 2.24861
ARMCX1 armadillo repeat containing, X-linked 1 2.24064
USP9Y ubiquitin specific peptidase 9, Y-linked 2.23893
TSPAN6 tetraspanin 6 2.2344
GPER1 G protein-coupled estrogen receptor 1 2.22912
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 2.22833
TENM4 teneurin transmembrane protein 4 2.22601
FAM200C family with sequence similarity 200 member C 2.22329
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 2.22194
ZNF280B zinc finger protein 280B 2.22036
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2.21861
TEC tec protein tyrosine kinase 2.21842
CCDC30 coiled-coil domain containing 30 2.21312
ZNF197 zinc finger protein 197 2.2104
IMPACT impact RWD domain protein 2.20948
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.20683
GLRA2 glycine receptor, alpha 2 2.20683
MATN3 matrilin 3 2.20613
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.19245
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2.18878
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2.18579
ASDURF ASNSD1 upstream open reading frame 2.17051
RIT2 Ras-like without CAAX 2 2.16504
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.16501
HOXA10 homeobox A10 2.16202
MCFD2 multiple coagulation factor deficiency 2 2.16069
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like 2.15923
FBXO3 F-box protein 3 2.15043
MFF mitochondrial fission factor 2.14901
SFRP4 secreted frizzled-related protein 4 2.14159
NLGN4Y neuroligin 4, Y-linked 2.14095
STAU2 staufen double-stranded RNA binding protein 2 2.13739
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 2.13389
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 2.13285
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 2.13005
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough 2.12947
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 2.1268
CADM1 cell adhesion molecule 1 2.12455
CETN3 centrin, EF-hand protein, 3 2.1236
SIDT1 SID1 transmembrane family, member 1 2.12151
ZNF329 zinc finger protein 329 2.11991
MRPS18C mitochondrial ribosomal protein S18C 2.11583
RBM15B RNA binding motif protein 15B 2.11393
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.11268
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.10807
WDR7 WD repeat domain 7 2.10655
TBL1Y transducin (beta)-like 1, Y-linked 2.1033
ZNF135 zinc finger protein 135 2.09987
SOX5 SRY (sex determining region Y)-box 5 2.09855
FAM124B family with sequence similarity 124B 2.0983
RNF111 ring finger protein 111 2.09599
ENC1 ectodermal-neural cortex 1 (with BTB domain) 2.09535
NELL1 NEL-like 1 (chicken) 2.08941
DCK deoxycytidine kinase 2.08604
TRMT61B tRNA methyltransferase 61B 2.08259
UGP2 UDP-glucose pyrophosphorylase 2 2.0773
H1-4 H1.4 linker histone, cluster member 2.0757
ADGRB3 adhesion G protein-coupled receptor B3 2.07052
ABI3BP ABI family, member 3 (NESH) binding protein 2.05953
SPIN2B spindlin family, member 2B 2.0592
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.05573
KDM5D lysine (K)-specific demethylase 5D 2.04994
HDAC2 histone deacetylase 2 2.04576
DCAF4 DDB1 and CUL4 associated factor 4 2.04078
BCL2A1 BCL2-related protein A1 2.03805
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.03791
CLCN5 chloride channel, voltage-sensitive 5 2.03573
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 2.03118
CNTNAP1 contactin associated protein 1 2.01727
PCDHGA8 protocadherin gamma subfamily A, 8 2.0168
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.01528
RBM48 RNA binding motif protein 48 2.01396
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.01296
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 2.01109
ZNF529 zinc finger protein 529 2.00841
EID1 EP300 interacting inhibitor of differentiation 1 2.00234
EDA2R ectodysplasin A2 receptor 2.00112

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -5.26288
HMG20B high mobility group 20B -5.25141
TUBA4A tubulin, alpha 4a -5.12357
RNF167 ring finger protein 167 -4.76528
CHMP4B charged multivesicular body protein 4B -4.141
STXBP2 syntaxin binding protein 2 -4.06593
ETFB electron-transfer-flavoprotein, beta polypeptide -4.03675
KIF14 kinesin family member 14 -3.75727
DDIT4 DNA-damage-inducible transcript 4 -3.74701
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -3.55892
MSN moesin -3.48448
MVP major vault protein -3.46324
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.34693
NUDC nudC nuclear distribution protein -3.23354
PUF60 poly-U binding splicing factor 60KDa -3.20897
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -3.1448
TWF2 twinfilin actin binding protein 2 -3.13188
GFUS GDP-L-fucose synthase -3.00119
BAD BCL2-associated agonist of cell death -2.98527
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.98005
ECH1 enoyl CoA hydratase 1, peroxisomal -2.95364
PFN1 profilin 1 -2.88496
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.87915
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.8694
VAT1 vesicle amine transport 1 -2.86421
TNIP1 TNFAIP3 interacting protein 1 -2.86299
MT2A metallothionein 2A -2.82368
PLK1 polo-like kinase 1 -2.80394
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) -2.77372
CBR3 carbonyl reductase 3 -2.74914
MT1X metallothionein 1X -2.74843
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.74661
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.71344
ADGRE5 adhesion G protein-coupled receptor E5 -2.70614
DDB2 damage-specific DNA binding protein 2, 48kDa -2.70008
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.69409
HSPB1 heat shock 27kDa protein 1 -2.66949
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.59027
KIF2C kinesin family member 2C -2.56071
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.55059
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.54837
FAM50A family with sequence similarity 50, member A -2.5297
RPL8 ribosomal protein L8 -2.51273
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.51072
ANXA2 annexin A2 -2.51072
UQCRC1 ubiquinol-cytochrome c reductase core protein I -2.49282
ILK integrin-linked kinase -2.45174
GRN granulin -2.45116
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.4333
TIMP1 TIMP metallopeptidase inhibitor 1 -2.40009
RPS5 ribosomal protein S5 -2.37893
LOC112694756 uncharaterized LOC112694756 -2.3581
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -2.35644
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -2.34662
LOC114841035 uncharacterized LOC114841035 -2.34553
TKT transketolase -2.34346
FLNA filamin A, alpha -2.33028
ACTN4 actinin, alpha 4 -2.32743
COG4 component of oligomeric golgi complex 4 -2.31715
AP2M1 adaptor-related protein complex 2, mu 1 subunit -2.31667
BRMS1L breast cancer metastasis-suppressor 1-like -2.31468
TAC4 tachykinin 4 (hemokinin) -2.29992
TM9SF3 transmembrane 9 superfamily member 3 -2.29703
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -2.29062
INTS3 integrator complex subunit 3 -2.28099
SMC1A structural maintenance of chromosomes 1A -2.27983
TUFM Tu translation elongation factor, mitochondrial -2.27971
GPS1 G protein pathway suppressor 1 -2.27806
FPGS folylpolyglutamate synthase -2.2596
MRPL12 mitochondrial ribosomal protein L12 -2.23195
BSG basigin (Ok blood group) -2.20176
BLCAP bladder cancer associated protein -2.1903
TECR trans-2,3-enoyl-CoA reductase -2.18754
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase -2.17461
OXA1L oxidase (cytochrome c) assembly 1-like -2.16743
RPL18A ribosomal protein L18a -2.16007
RPL18 ribosomal protein L18 -2.15694
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.15481
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.15012
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.13492
CAPNS1 calpain, small subunit 1 -2.1265
PINK1 PTEN induced putative kinase 1 -2.11842
ATP13A1 ATPase type 13A1 -2.1175
CCDC86 coiled-coil domain containing 86 -2.09506
EHBP1L1 EH domain binding protein 1-like 1 -2.08488
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -2.07222
BCAP31 B-cell receptor-associated protein 31 -2.06852
SF3B2 splicing factor 3b, subunit 2, 145kDa -2.06839
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.06689
STIP1 stress-induced phosphoprotein 1 -2.06416
GSTP1 glutathione S-transferase pi 1 -2.05851
RBM42 RNA binding motif protein 42 -2.05475
CSF1R colony stimulating factor 1 receptor -2.05367
MRPS2 mitochondrial ribosomal protein S2 -2.04797
P4HB prolyl 4-hydroxylase, beta polypeptide -2.04695
UBA1 ubiquitin-like modifier activating enzyme 1 -2.04474
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.04191
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.03888
GAA glucosidase, alpha; acid -2.03697
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -2.03324
DDB1 damage-specific DNA binding protein 1, 127kDa -2.03262
BCKDK branched chain ketoacid dehydrogenase kinase -2.03197
DNM2 dynamin 2 -2.02507
PGAM4 phosphoglycerate mutase family member 4 -2.02326
BORCS6 BLOC-1 related complex subunit 6 -2.01757
SIRT7 sirtuin 7 -2.01074
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha -2.00938
USF2 upstream transcription factor 2, c-fos interacting -2.00423