CRCGN016_MCF10A.TP53.M_24H:O23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tolazamide 33.66 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

95 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:O23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ANO10 anoctamin 10 3.99828
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.84331
CCNA1 cyclin A1 3.76315
GADD45A growth arrest and DNA-damage-inducible, alpha 3.71784
COMP cartilage oligomeric matrix protein 3.68306
CNRIP1 cannabinoid receptor interacting protein 1 3.59602
APOE apolipoprotein E 3.42504
KLHL21 kelch-like family member 21 3.40335
NRBF2 nuclear receptor binding factor 2 3.27595
ACAA1 acetyl-CoA acyltransferase 1 3.14338
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.0182
CCDC85B coiled-coil domain containing 85B 2.99724
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.93851
DBF4 DBF4 zinc finger 2.58582
ARHGAP22 Rho GTPase activating protein 22 2.506
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.49942
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.49251
LY75-CD302 LY75-CD302 readthrough 2.47513
TGFB3 transforming growth factor, beta 3 2.4683
PNMA8A PNMA family member 8A 2.45092
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 2.41837
IGFBP3 insulin-like growth factor binding protein 3 2.40163
ZNF518A zinc finger protein 518A 2.38692
SLC38A6 solute carrier family 38, member 6 2.36612
RIDA reactive intermediate imine deaminase A homolog 2.31661
KCTD11 potassium channel tetramerization domain containing 11 2.27574
FLCN folliculin 2.26181
RINT1 RAD50 interactor 1 2.25381
ARHGAP8 Rho GTPase activating protein 8 2.24967
ELMO1 engulfment and cell motility 1 2.23319
FUBP3 far upstream element (FUSE) binding protein 3 2.22763
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 2.22333
CGRRF1 cell growth regulator with ring finger domain 1 2.22291
GHR growth hormone receptor 2.21031
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.20446
AK5 adenylate kinase 5 2.19629
FCHO1 FCH domain only 1 2.18459
PDLIM1 PDZ and LIM domain 1 2.18222
CTSW cathepsin W 2.15765
AP3M2 adaptor-related protein complex 3, mu 2 subunit 2.1483
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.14458
WIF1 WNT inhibitory factor 1 2.12697
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 2.11169
GOLGA7 golgin A7 2.09828
THAP1 THAP domain containing, apoptosis associated protein 1 2.09107
ZNF267 zinc finger protein 267 2.09097
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.09064
BACE1 beta-site APP-cleaving enzyme 1 2.089
CHUK conserved helix-loop-helix ubiquitous kinase 2.08312
JADE3 jade family PHD finger 3 2.05536
SPAG4 sperm associated antigen 4 2.05333
LGSN lengsin, lens protein with glutamine synthetase domain 2.01748
EFHD2 EF-hand domain family, member D2 2.01634
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.00339

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -5.60798
KRT14 keratin 14, type I -4.55668
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.28246
IFRD2 interferon-related developmental regulator 2 -3.18322
ANKRD10 ankyrin repeat domain 10 -3.07858
NGRN neugrin, neurite outgrowth associated -3.05558
PARP3 poly (ADP-ribose) polymerase family, member 3 -2.80564
TMED1 transmembrane emp24 protein transport domain containing 1 -2.68197
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.59781
DRG2 developmentally regulated GTP binding protein 2 -2.57151
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.49533
TRIB3 tribbles pseudokinase 3 -2.48173
AUP1 ancient ubiquitous protein 1 -2.40982
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -2.40001
RNF123 ring finger protein 123 -2.35435
RPL29 ribosomal protein L29 -2.32004
TKT transketolase -2.30934
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.30436
PIH1D1 PIH1 domain containing 1 -2.28928
TMEM115 transmembrane protein 115 -2.2584
OCEL1 occludin/ELL domain containing 1 -2.25787
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -2.22251
LOX lysyl oxidase -2.17821
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -2.15183
ETFB electron-transfer-flavoprotein, beta polypeptide -2.1482
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.14626
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.13899
TMEM214 transmembrane protein 214 -2.13581
CUL4A cullin 4A -2.12904
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -2.11342
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.09754
GBP2 guanylate binding protein 2, interferon-inducible -2.0925
GFUS GDP-L-fucose synthase -2.07278
TXNDC9 thioredoxin domain containing 9 -2.06991
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.06356
OXA1L oxidase (cytochrome c) assembly 1-like -2.04877
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -2.0397
TCTN2 tectonic family member 2 -2.03825
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.0316
MST1R macrophage stimulating 1 receptor -2.03142
ACOX2 acyl-CoA oxidase 2, branched chain -2.01093