CRCGN016_MCF10A.TP53.M_24H:O24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tolazamide 11.22 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:O24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 5.50122
ZNF586 zinc finger protein 586 5.1696
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 4.1001
ACAA1 acetyl-CoA acyltransferase 1 4.02305
ZNF134 zinc finger protein 134 3.56805
ZNF587B zinc finger protein 587B 3.53465
ZNF551 zinc finger protein 551 3.05095
COMP cartilage oligomeric matrix protein 3.0268
ZIM3 zinc finger, imprinted 3 2.7911
TBPL1 TBP-like 1 2.7638
ZNF304 zinc finger protein 304 2.6718
NUCB2 nucleobindin 2 2.6306
CDCA4 cell division cycle associated 4 2.5876
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.40685
ZNF671 zinc finger protein 671 2.39855
SMNDC1 survival motor neuron domain containing 1 2.36425
FANCF Fanconi anemia, complementation group F 2.33835
ZNF587 zinc finger protein 587 2.2887
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.28655
LYRM1 LYR motif containing 1 2.2613
CADM1 cell adhesion molecule 1 2.21303
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.1774
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.1713
LNPEP leucyl/cystinyl aminopeptidase 2.13375
TMX2 thioredoxin-related transmembrane protein 2 2.1256
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.11285
ZNF329 zinc finger protein 329 2.1117
GFRA1 GDNF family receptor alpha 1 2.10065
ZNF548 zinc finger protein 548 2.07355
ZNF135 zinc finger protein 135 2.06585
ZNF136 zinc finger protein 136 2.0636
ZNF761 zinc finger protein 761 2.0513
TRAPPC2 trafficking protein particle complex 2 2.01325
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.01185

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.2904
NRIP1 nuclear receptor interacting protein 1 -4.06395
CBR3 carbonyl reductase 3 -3.72005
PIH1D1 PIH1 domain containing 1 -3.38845
GRN granulin -3.0956
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.85028
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.5549
DGKD diacylglycerol kinase, delta 130kDa -2.5508
CDK5RAP3 CDK5 regulatory subunit associated protein 3 -2.53565
BLCAP bladder cancer associated protein -2.4593
GOLGA8A golgin A8 family, member A -2.4226
JMJD6 jumonji domain containing 6 -2.31988
GOLGA8N golgin A8 family, member N -2.3048
AARS1 alanyl-tRNA synthetase 1 -2.29745
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.21588
TAC4 tachykinin 4 (hemokinin) -2.176
RPS5 ribosomal protein S5 -2.1495
RGS2 regulator of G-protein signaling 2 -2.1365
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.1269
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -2.03375